Direct induction of CCK and GLP‐1 release from murine endocrine cells by intact dietary proteins

Geraedts, Maartje C. P.; Troost, Freddy J.; Fischer, Marc A. J. G.; Edens, Luppo; Saris, Wim H. M.

doi:10.1002/mnfr.201000142

Cited by 81 publications

(94 citation statements)

References 41 publications

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“…Cheng et al [21] demonstrated that ghrelin inhibited MLCK activity in the rat intestine. In addition, Geraedts et al [22] indicated that protein intake increased glucagon-like peptide 1 (GLP-1) production in humans. GLP-1 could inhibit apoptosis and reduce JNK activity in human umbilical vein endothelial cells [23].…”

Section: Introductionmentioning

confidence: 99%

Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

Jiang

et al. 2016

Fish & Shellfish Immunology

123

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Section: Introductionmentioning

confidence: 99%

Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

Jiang

et al. 2016

Fish & Shellfish Immunology

123

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“…[12][13][14] Some intact or partially digested proteins (peptone) exert strong stimulatory effects on CCK and other released satiety hormones and may therefore be applicable as functional food components to prevent over-eating. 15) Cuber et al 16) found that peptones, and not whole protein, carbohydrates or fats were strong stimulants of CCK release in the isolated rat duodenojejunum. Cordier-Bussat et al 11) have also proved that peptones directly stimulated CCK secretion in STC-1 cells.…”

mentioning

confidence: 99%

Suppressive Effect on Food Intake of a Potato Extract (Potein<sup>®</sup>) Involving Cholecystokinin Release in Rats

Chen

Hira

Nakajima

et al. 2012

Bioscience, Biotechnology, and Biochemistry

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“…For the improvement of glucose metabolism, incretin secretion stimulants and dipeptidyl peptidase-4 inhibitors from food proteins such as rice, wheat, and zein have been investigated (18)(19)(20). EWH also stimulates the release of GLP-1 in STC-1 cells (21). However, the plasma total GLP-1 level in both fasting and non-fasting states and the fasting plasma adiponectin level were not unexpectedly changed by the EW and EWH diets ( Table 2).…”

Section: Resultsmentioning

confidence: 99%

Egg White Hydrolysate Improves Glucose Tolerance in Type-2 Diabetic NSY Mice

Ochiai

Azuma

2017

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryWe have previously reported that chicken egg white (EW) and low-allergenic EW hydrolysate (EWH) suppressed ectopic fat accumulation and improved serum glucose and insulin levels. In this study, the dietary effects of EW and EWH on glucose tolerance were investigated in different ways to clarify the effect of EW and EWH on intestinal glucose absorption. Type 2 diabetic Nagoya-Shibata-Yasuda mice were divided into four groups: a low-fat and low-sucrose casein-based diet group (NL); high-fat and high-sucrose (HFS) casein-based diet group (NH); HFS EW-based diet group (NE); and HFS EWH-based diet group (NEH). Mice were fed their respective diets for 8 wk. At the end of the 6th and 7th week, an oral glucose tolerance test (OGTT) and insulin tolerance test (ITT) were respectively conducted in experiment A. At the end of the 7th week, an intraperitoneal glucose tolerance test (ipGTT) was conducted in experiment B. In experiment A, the plasma glucose level was suppressed in the NE group during both OGTT and ITT, and suppressed in the NEH group during OGTT, but not during ITT. In experiment B, the plasma glucose level was similarly suppressed in the NEH group during ipGTT, but the suppressive effect was weakened compared to OGTT. Plasma insulin level was lower in the NE and NEH groups in both experiments. Fecal triacylglycerol excretion was increased in the NE and NEH groups in experiment A and liver triacylglycerol content was suppressed in the NE group in experiment B. These findings suggested that in addition to improving fat metabolism, EWH improves glucose tolerance via mechanisms related and unrelated to small intestinal function. Key Words egg white hydrolysate, glucose tolerance, oral administration, intraperitoneal injection, Nagoya-Shibata-Yasuda mice Chicken egg white (EW) makes up about 60% of the whole egg weight and contains proteins high in amino acid balance. EW has been reported to suppress food intake, dietary fat absorption, and fat accumulation in rats in our previous studies (1-3); therefore, EW can be considered for the prevention and treatment of obesity and type 2 diabetes mellitus (T2DM) in humans. However, egg-specific proteins in EW are well known to be major allergens in humans. Continuous consumption of EW or whole egg can induce allergic symptoms in humans; therefore, it is necessary to produce low-allergenic EW products. Recently, low-allergenic bioactive peptides derived from EW have been developed and purified for the prevention and improvement of several metabolic disorders such as hypertension and oxidative stress (4-6). However, few studies have reported the effects of low-allergenic EW products on glucose metabolism.We previously developed EW enzymatic hydrolysate (EWH), which contains less allergenic proteins and has similar physicochemical properties to EW (3). We have also reported that EWH improves fasting serum glucose and insulin levels in diabetic Goto-Kakizaki (GK) rats (1) and Wistar rats (2). These findings suggest that in addition to improving fat metabolism, EWH can...

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Direct induction of CCK and GLP‐1 release from murine endocrine cells by intact dietary proteins

Cited by 81 publications

References 41 publications

Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

Suppressive Effect on Food Intake of a Potato Extract (Potein<sup>®</sup>) Involving Cholecystokinin Release in Rats

Egg White Hydrolysate Improves Glucose Tolerance in Type-2 Diabetic NSY Mice

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Direct induction of CCK and GLP‐1 release from murine endocrine cells by intact dietary proteins

Cited by 81 publications

References 41 publications

Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

Optimal dietary protein level improved growth, disease resistance, intestinal immune and physical barrier function of young grass carp (Ctenopharyngodon idella)

Suppressive Effect on Food Intake of a Potato Extract (Potein<sup>&reg;</sup>) Involving Cholecystokinin Release in Rats

Egg White Hydrolysate Improves Glucose Tolerance in Type-2 Diabetic NSY Mice

Contact Info

Product

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Suppressive Effect on Food Intake of a Potato Extract (Potein<sup>®</sup>) Involving Cholecystokinin Release in Rats