The technology of application of pesticides, fertilizers and other agrochemicals by unmanned aerial vehicles (UAVs) in the precision farming system provides for differentiated treatment of agricultural fields with variable standards of pesticides and differentiated application of fertilizers. Existing UAVs do not provide differentiated fertilization of plants with fertilizers and differentiated treatment of plants with pesticides due to imperfect flow control systems and working fluid application rates. Substantiation of methods for regulating the flow rate and norms of working fluids of pesticides and fertilizers is based on the flow continuity equations, Bernoulli and the equation that determines the rate and dose of pesticides and fertilizers depending on the operational and technological parameters of the UAV. The paper shows that to differentiate the norms for applying the working fluid of pesticides and fertilizers, it is advisable to use methods for regulating the norms by changing the area of the outlet openings of sprayers and the step of their placement, while differentiating the norms can be carried out both by a combination of these methods and by including one or several standard sizes in the work of sprayers simultaneously.