Discovery of cyclohexadepsipeptides with anti-Zika virus activities and biosynthesis of the nonproteinogenic building block (3S)-methyl-l-proline

Abstract

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Integrating Genomics and Metabolomics for the Targeted Discovery of New Cyclopeptides with Antifungal Activity from a Marine-Derived Fungus Beauveria felina

“…Based on bioinformatics and structural analyses of isaridins and destruxins, we propose a plausible biosynthetic pathway of isaridins ( 1–7 ) in B. felina (Figure ).…”

Marine natural products

“…Some of the known peptides exhibited weak inhibition of the Zika virus but the clarication of the biosynthetic pathway gives opportunities to engineer the pathway to potentially generate new anti-Zika virus cyclohexadepsipeptides. 178 Chemical analysis of a sh-gut-derived Chrysosporium sp. indicated the presence of trace amounts of aza analogues of chrysosporazines 412-417, yields of which were not improved by use of a microbioreactor cultivation proling analysis.…”

“…Some of the known peptides exhibited weak inhibition of the Zika virus but the clarification of the biosynthetic pathway gives opportunities to engineer the pathway to potentially generate new anti-Zika virus cyclohexadepsipeptides. 178…”

Fungal Guttation, a Source of Bioactive Compounds, and Its Ecological Role—A Review

“…Examined derivatives have exerted inhibitory effects on the expression of the hepatitis B surface antigen in human hepatoma cells carrying an integrated viral gene [ 66 , 67 ]. Additionally, destruxins of Beauveria felina , along with isaridins and isariins, have been evaluated for anti-Zika virus activities [ 68 ]. Some of the isolated compounds revealed inhibitory activity against Zika virus RNA replication and, interestingly, the observed effect in the infected A549 cell line model was stronger than for ivermectin, used due to its high antiviral efficacy as a positive control.…”

“…Some of the isolated compounds revealed inhibitory activity against Zika virus RNA replication and, interestingly, the observed effect in the infected A549 cell line model was stronger than for ivermectin, used due to its high antiviral efficacy as a positive control. Moreover, tested cyclohexadepsipeptides blocked virus entry and downregulated the production of NS5, an essential protein for viral replication [ 68 ]. Furthermore, some destruxins are antibacterial agents [ 69 ], and possess similar structure pseudoxylallemycins ( Figure 3 c), which have antibacterial and antineoplastic properties (see Section 4.4 ) [ 27 ].…”