“…Ion mobility spectrometer (IMS) ( Eiceman et al, 2013 ; Sorribes-Soriano et al, 2018 ) is an analytical instrument working at atmospheric pressure. It has a wide range of applications in many fields, such as drug detection ( Zou et al, 2018 ), medical diagnosis ( Ruszkiewicz et al, 2020 ), and compound analysis ( Han and Yao, 2020 ; Wu et al, 2021 ). IMS has many kinds of derivatives, such as Travelling wave ion mobility spectrometry (TW-IMS) ( Giles et al, 2004 ; Pringle et al, 2007 ), Trapped ion mobility spectrometry (TIMS) ( Fernandez-Lima et al, 2011b , a ), Differential or field asymmetric ion mobility spectrometry (DMS/FAIMS) ( Buryakov et al, 1993 , 1991 ), Fourier transform ion mobility spectrometry (FT-IMS) ( Knorr et al, 1985 ), Hadamard transform ion mobility spectrometry (HT-IMS) ( Clowers et al, 2006 ; Szumlas et al, 2006 ), etc.…”