Disease severity and treatment in adolescent idiopathic scoliosis: the impact of race and economic status

Zavatsky, Joseph M.; Peters, Austin; Nahvi, Farzon A.; Bharucha, Neil J.; Trobisch, Per; Kean, Kristin E.; Richard, Sandra; Bucello, Yolanda; Valdevit, Antonio; Lonner, Baron S.

doi:10.1016/j.spinee.2013.06.043

Cited by 53 publications

(65 citation statements)

References 23 publications

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“…Some might entertain that the imbalances in confounding factors between study groups, such as patient sex and ethnicity could have led to analytical bias. For example, because African Americans may exhibit higher morphine clearance, more preoperative pain, and a higher degree of scoliosis, an imbalanced ethnic composition between ketamine and placebo groups could have impacted the results (29)(30)(31). Similarly, we note imbalances in the number of males and females between the two study groups.…”

Section: Discussionmentioning

confidence: 85%

Prolonged perioperative infusion of low‐dose ketamine does not alter opioid use after pediatric scoliosis surgery

Pestieau

Finkel

Junqueira

et al. 2014

Pediatric Anesthesia

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Section: Discussionmentioning

confidence: 85%

Prolonged perioperative infusion of low‐dose ketamine does not alter opioid use after pediatric scoliosis surgery

Pestieau

Finkel

Junqueira

et al. 2014

Pediatric Anesthesia

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“…Similar to our study's approach, Tilley et al [14] included patients with a Cobb angle greater than 10°and distinguished four subgroups with values of ≥10°, ≥15°, ≥20°, and ≥ 30°. The Cobb angle value of ≥10°u sed in classifying IS in this study was selected in accordance to the standard criteria recommended by the Scoliosis Research Society [19]. In both the papers mentioned above, the authors researched the familial associations of IS cases with genetic polymorphisms but they did not do a case-control study of genetic alternations occurrence and IS phenotype.…”

Section: Discussionmentioning

confidence: 99%

CHD7 gene polymorphisms in female patients with idiopathic scoliosis

Borysiak

Janusz

Andrusiewicz

et al. 2020

BMC Musculoskelet Disord

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Background: The CHD7 (chromosome domain helicase DNA binding protein 7) gene has been associated with familial idiopathic scoliosis (IS) in families of European descent. The CHD7 single-nucleotide polymorphisms have never been studied in Polish Caucasian IS patients. Methods: The aim of this study was to investigate the relationship of CHD7 gene polymorphisms with susceptibility to or progression of IS in Polish Caucasian females. The study group comprised 211 females who underwent clinical, radiological and genetic examination. The study group was analyzed in three subgroups according to: (1) Cobb angle (Cobb angle ≤30°vs. Cobb angle ≥35°), (2) age of diagnosis (adolescent IS vs. early-onset IS) and (3) rate of progression (non-progressive vs. slowly progressive vs. rapidly progressive IS). The control group comprised 83 females with no scoliosis and with a negative family history who underwent clinical and genetic examination. In total six CHD7 gene polymorphisms were examined. Three polymorphisms (rs1017861, rs13248429, and rs4738813) were examined by RFLP (restriction fragment length polymorphism) analysis, and three were quantified by Sanger sequencing (rs78874766, rs4738824, and rs74797613). Results: In rs13248429, rs78874766, and rs74797613 polymorphisms only the wild allele was present. The rs1017861 polymorphism demonstrated an association with IS susceptibility (p < 0.01). Two polymorphisms, rs1017861 and rs4738813, were associated with curve severity and progression rate (p < 0.05). None of the evaluated polymorphisms in CHD7 gene showed any association with the age of IS onset. Conclusions: The polymorphism rs1017861 in CHD7 gene showed an association with IS susceptibility. Two polymorphisms (rs1017861 and rs4738813) were associated with curve severity and progression rate. None of the evaluated polymorphisms in CHD7 gene showed any association with the age of IS onset. Further evaluation of CHD7 gene should be considered as IS modifying factor.

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“…Race may influence an individual’s natural spinopelvic alignment [ 23 ]. The prevalence of scoliosis differs among races [ 24 , 25 ], and curve severity is associated with race [ 25 , 26 ]. Kebaish et al [ 25 ] found that the prevalence of scoliosis was 11.1 % for whites and 6.5 % for African Americans.…”

Section: Introductionmentioning

confidence: 99%

“…Kebaish et al [ 25 ] found that the prevalence of scoliosis was 11.1 % for whites and 6.5 % for African Americans. Zavatsky et al [ 26 ] found that curve magnitude was greater in black patients than in white patients (33° vs. 28°). A study found that the prevalence of scoliosis in Chinese girls was significantly higher than in Malay and Indian girls aged 11 to 12 and 16 to 17 years [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Scoliosis epidemiology is not similar all over the world: a study from a scoliosis school screening on Chongming Island (China)

Négrini

Chen

et al. 2016

BMC Musculoskelet Disord

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BackgroundSchool scoliosis screening has been carried out around the world. The screen program has never been performed on Chongming Island, the third largest island in China and characterized less population exchange with the rest of China. This study was designed to examine scoliotic parameters in children from Chongming Island and determine whether the parameters differed from those of the published data.MethodsA total of 6824 children (3477 boys and 3347 girls) aged from 6 to 17 were recruited. The screen included Adam’s test and scoliometer measurements. Posteroanterior radiographic evaluation was performed if trunk rotation was 5° or more.ResultsOne hundred seventy two were confirmed with Cobb angle of 10° or more; the prevalence was 2.52 %, higher in girls (3.11 %) than in boys (1.96 %) (p < 0.05). There was a weak positive correlation between prevalence and age. Majority curves were minor (from 10 to 19°). The most common thoracic curve was right curve (60.3 % of all thoracic curves), while the most common thoracolumbar (75.5 %) and lumbar curves (64.7 %) were left curves.ConclusionsThe prevalence of scoliosis on Chongming Island was 2.52 %. This study indicates that epidemiology of scoliosis has regional variation, and genetic differences may contribute such difference.Electronic supplementary materialThe online version of this article (doi:10.1186/s12891-016-1140-6) contains supplementary material, which is available to authorized users.

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Disease severity and treatment in adolescent idiopathic scoliosis: the impact of race and economic status

Cited by 53 publications

References 23 publications

Prolonged perioperative infusion of low‐dose ketamine does not alter opioid use after pediatric scoliosis surgery

Prolonged perioperative infusion of low‐dose ketamine does not alter opioid use after pediatric scoliosis surgery

CHD7 gene polymorphisms in female patients with idiopathic scoliosis

Scoliosis epidemiology is not similar all over the world: a study from a scoliosis school screening on Chongming Island (China)

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