Disinfectants

Harke, Hans-P.

doi:10.1002/14356007.a08_551

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…Alcohols are widely known as antibacterial agents. Those are used in many antiseptics and disinfectants as active substances [ 20 ], in cosmetic products as preservatives [ 21 ], etc. Alcohol-based hand sanitizers are recommended by WHO as preventive measures against COVID-19 [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

Microbiological Evaluation of Novel Bis-Quaternary Ammonium Compounds: Clinical Strains, Biofilms, and Resistance Study

et al. 2022

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This work is devoted to the investigation of biocidal properties of quaternary ammonium compounds (QACs) based on pyridine structures with aromatic spacers, and their widely known analogs, against clinically significant microorganisms. This study is focused on investigating their antimicrobial activity (minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs)), antibiofilm properties (minimum biofilm inhibitory concentrations (MBICs) and minimum biofilm eradication concentrations (MBECs)), synergetic effect with different alcohols in antiseptic formulations, and bacterial resistance development. It was shown that all combined analogue preparations had a higher level of antibacterial activity against the tested bacterial strains, with a 16- to 32-fold reduction in MICs and MBCs compared to previously used antiseptic preparations. Moreover, hit-QACs demonstrated a stable effect against Gram-negative E. coli, K. pneumoniae, and A. baumannii within a month of incubation. Overall results indicated a high level of antibacterial activity of pyridine-based QACs.

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Section: Resultsmentioning

confidence: 99%

Microbiological Evaluation of Novel Bis-Quaternary Ammonium Compounds: Clinical Strains, Biofilms, and Resistance Study

et al. 2022

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“…Активний in vitro щодо біоплівок, утворених лікарняними штамами мікроорганізмів [62]. Проте ОД має певні недоліки: є отруйним у разі парентерального введення і може викликати місцеві подразнення [63].…”

Section: ■ результати та їх обговорення 1) пероксидні сполукиunclassified

Modern chemical disinfectants and antiseptics. Part II

Britsun¹,

Simurova²,

Popova³

et al. 2021

J. Org. Pharm. Chem.

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Aim. To generalize and systematize information on the properties of modern chemical disinfectants and antiseptic agents (DA and AA) – peroxide compounds, surfactants, salts of heavy metals and metals of variable valence in the highest oxidation state, alcohols, phenols and quaternary ammonium salts.Results and discussion. The classification of DA and AA by the chemical structure was performed. The spectrum of their activity, directions and forms of DA and AA were given. Toxicity and the impact on the environment were described.Conclusions. The results of the study conducted allow us to state that modern DA and AA of a wide spectrum of action are peracetic acid and, to a certain extent, hydrogen peroxide. However, they are unstable in dilute solutions. Other reagents are chemically stable, but they are characterized by a weak or average action against spores and viruses. The most effective DA and AA are mixtures (combinations) of compounds belonging to different classes. The examples of these combinations are “surfactants + biguanidine derivatives”; “quaternary ammonium salts + phenol derivatives”; “surfactants + aldehydes”; “quaternary ammonium salts + hydrogen peroxide”. These mixtures combine the advantages and compensate for the disadvantages of individual DA and AA.

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“…OCT compounds have demonstrated no impairment of wound healing and lower colonization of bacteria on wound beds 35 . In animal trials, it was found to more effective to reduce bacterial counts in eschar than silver sulfadiazine 36 , and it has been demonstrated to be effective against bacteria at lower concentrations than chlorhexidine 37,38 . In a small study, octenidine dihydrochloride was found to be more effective to treat P. aeruginosa -contaminated burn wounds than povidone iodine 39 , and generally more active against the other bacterial strains most commonly isolated from burn wounds than most topical antimicrobials, including silver sulfadiazine, Betadine ® (Purdue Products LP, Stamford, CT, USA), and Acticoat ® (Smith & Nephew ™ , London, England, UK) 40 .…”

Section: Classificationmentioning

confidence: 99%

Topical Antimicrobials in Burn Care

Cambiaso‐Daniel¹,

Boukovalas²,

Bitz³

et al. 2018

Annals of Plastic Surgery

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Burn wounds disrupt the body’s primary defense against invasion and colonization by microorganisms. Topical antimicrobials are one component in burn wound care. These agents suppress microbial growth to advantage skin cells and wound healing. Topical antimicrobials can be divided into two superclasses: antiseptics and antibiotics. Herein we review the four main classes of topical antiseptics (emulsifiers, acids, oxidizers, and heavy metals) as well as antiseptic-impregnated dressings in current clinical use and address the mechanisms as well as the advantages and disadvantages of each antiseptic for burn wound management.

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Disinfectants

Cited by 4 publications

References 20 publications

Microbiological Evaluation of Novel Bis-Quaternary Ammonium Compounds: Clinical Strains, Biofilms, and Resistance Study

Microbiological Evaluation of Novel Bis-Quaternary Ammonium Compounds: Clinical Strains, Biofilms, and Resistance Study

Modern chemical disinfectants and antiseptics. Part II

Topical Antimicrobials in Burn Care

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