Disseminated coxsackievirus A6 affecting children with atopic dermatitis

Lynch, Magnus; Sears, Alison; Cookson, Hannah; Lew, T.; Laftah, Zainab; Orrin, L.; Zuckerman, Mark; Creamer, Daniel; Higgins, E. M.

doi:10.1111/ced.12574

Cited by 12 publications

(10 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CV-A6 infection should be considered in the differential diagnosis of an acute exacerbation of atopic dermatitis (AD)31 and herpes zoster32, particularly in children, and specific warnings should be given to patients with CV-A6 infection because desquamation, onychomadesis or nail abnormalities can occur between one week to two months1617181920. CV-A10 infection has most commonly been associated with more mild disease33 while infections with many other EVs serotypes may be severe and even fatal.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of 45,616 suspect cases of Hand, Foot and Mouth Disease in Chongqing, China, 2011–2015

Tao

Shi

et al. 2017

Sci Rep

View full text Add to dashboard Cite

Epidemiology and etiology of hand, foot, and mouth disease (HFMD) based on large sample size or evaluation of detection for more enterovirus serotypes are not well investigated in Chongqing of China. 45,616 suspect HFMD patients were prospectively enrolled among whom 21,615 were laboratory confirmed HFMD cases over a 5-year period (January 2011 to December 2015). Their epidemiological, clinical, and laboratory data were extracted and stratified by month, age, sex, disease severity, and enterovirus serotype. Subsequently 292 non-EV-A71/CV-A16 HFMD confirmed cases were randomly selected in three consecutive outbreaks to detect CV-A6 and CV-A10, using RT-PCR. Results showed that the HFMD epidemic peaked in early summer and autumn. The median age of onset was 2.45 years with a male-to-female ratio of 1.54:1, and with children under 5 years of age accounting for 92.54% of all confirmed cases. EV-A71 and CV-A16 infection accounted for only 36.05% (7793/21615) of total confirmed cases while EV-A71 accounted for 59.64% (232/389) of severe cases. Importantly, the proportion of EV-A71 infection generally increased with age which showed rapid growth in severe cases. CV-A6 and CV-A10 were tested positive in Chongqing, but CV-A6 had greater positive rates of 62.33% while CV-A10 had 4.79% in non-EV-A71/CV-A16 HFMD confirmed cases.

show abstract

Section: Discussionmentioning

confidence: 99%

Epidemiology of 45,616 suspect cases of Hand, Foot and Mouth Disease in Chongqing, China, 2011–2015

Tao

Shi

et al. 2017

Sci Rep

View full text Add to dashboard Cite

show abstract

“…The Coxsackie virus A6 strain leads to atypical disease manifestations, which are classified as diffuse form (lesions extended to the trunk), acral form (lesions with a mainly acral distribution) or eczema coxsackium (disseminated lesions on pre‐existing eczematous areas) . Symptomatic treatment includes use of topical steroids and wet wrap therapy …”

Section: Antimicrobial Therapymentioning

confidence: 99%

“…33 Symptomatic treatment includes use of topical steroids and wet wrap therapy. 34,35 Regional vaccination programmes should be followed by all AE patients as recommended. The denial of vaccination because of diagnosed AE is a misconception possibly leading to fatal consequences (see chapter: general measures).…”

Section: Antibacterialmentioning

confidence: 99%

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II

Wollenberg

Barbarot

Bieber

et al. 2018

Acad Dermatol Venereol

589

717

View full text Add to dashboard Cite

This guideline was developed as a joint interdisciplinary European project, including physicians from all relevant disciplines as well as patients. It is a consensus-based guideline, taking available evidence from other guidelines, systematic reviews and published studies into account. This second part of the guideline covers antimicrobial therapy, systemic treatment, allergen-specific immunotherapy, complementary medicine, psychosomatic counselling and educational interventions, whereas the first part covers methods, patient perspective, general measures and avoidance strategies, basic emollient treatment and bathing, dietary intervention, topical anti-inflammatory therapy, phototherapy and antipruritic therapy. Management of AE must consider the individual clinical variability of the disease. Systemic immunosuppressive treatment with cyclosporine, methotrexate, azathioprine and mycophenolic acid is established option for severe refractory cases, and widely available. Biologicals targeting the T helper 2 pathway such as dupilumab may be a safe and effective, disease-modifying alternative

show abstract

“…Increased risk of systemic infections has been demonstrated in pediatric patients with atopic dermatitis [17–21]. In adults, one small-scale study did find an increased risk of serious invasive pneumococcal disease in adults with AD [22].…”

Section: Discussionmentioning

confidence: 99%

“…Many of the studies were in the pediatric population [17–21], while the same risk in adult AD patients has not been thoroughly examined [14, 22, 23]. This study seeks to determine whether adult AD alone or AD with comorbid atopic disease is associated with higher odds of systemic infections compared to the general adult population in two large population-based observational surveys.…”

Section: Introductionmentioning

confidence: 99%

Adult Atopic Dermatitis with Comorbid Atopic Disease is Associated with Increased Risk of Infections: A Population-Based Cross-Sectional Study

Narala

Hata

2017

Dermatol Ther (Heidelb)

View full text Add to dashboard Cite

IntroductionAtopic dermatitis (AD) is related to other atopic diseases asthma and allergic rhinitis. It is known that those with asthma or allergic rhinitis have impaired immune responses that may predispose them to infections. This study sought to determine whether adult AD is associated with systemic infections, and whether association is strengthened in those with AD plus another atopic disease.MethodsThis cross-sectional study obtained information from adults in the 2010 and the 2012 National Health Interview Survey (NHIS). The primary exposure was history of AD without or with an additional atopic disease, asthma or allergic rhinitis. Self-reported systemic infections were the primary outcomes. Survey logistic regression was performed and adjusted odds ratios (aOR) reported.ResultsAD in NHIS 2010 was associated with increased risk of sinusitis [aOR (95% CIs): 1.65 (1.42, 1.91), P < 0.001], head or chest cold [1.31 (1.12, 1.52), P < 0.001], and gastrointestinal illness [2.39 (1.97, 2.89), P < 0.001], and in NHIS 2012, pneumonia/influenza [1.73 (1.54, 1.95), P < 0.001], strep throat/tonsillitis [1.72 (1.54, 1.92), P < 0.001], sinusitis [1.77 (1.54, 2.02), P < 0.001], head or chest cold [1.49 (1.33, 1.67), P < 0.001], and infectious disease [2.66 (2.20, 3.21), P < 0.001]. An increase in atopic disease mirrored an increase in number of infectious outcomes and was statistically significant in the combined dataset (P < 0.001).ConclusionThe associations between AD and AD plus another atopic disease with systemic infections suggest that an underlying immune defect may be contributing to microbial susceptibility. Further studies are warranted to understand the burden of infectious disease in this population.Electronic supplementary materialThe online version of this article (doi:10.1007/s13555-017-0172-7) contains supplementary material, which is available to authorized users.

show abstract

Disseminated coxsackievirus A6 affecting children with atopic dermatitis

Cited by 12 publications

References 10 publications

Epidemiology of 45,616 suspect cases of Hand, Foot and Mouth Disease in Chongqing, China, 2011–2015

Epidemiology of 45,616 suspect cases of Hand, Foot and Mouth Disease in Chongqing, China, 2011–2015

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II

Adult Atopic Dermatitis with Comorbid Atopic Disease is Associated with Increased Risk of Infections: A Population-Based Cross-Sectional Study

Contact Info

Product

Resources

About