Disseminated<i>Scedosporium prolificans</i>infection in a German Shepherd dog

Haynes, SM; Hodge, Penny; Tyrrell, D; Abraham, LA

doi:10.1111/j.1751-0813.2011.00870.x

Cited by 13 publications

(17 citation statements)

References 33 publications

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“…prolificans, 14 Scopulariopsis chartarum, 52 Aspergillus terreus, 34 Cryptococcus neoformans, 8 Candida albicans, 5 Ochroconis gallopavum, 46 Xylohypha bantiana, 43 and Acremonium spp. 45 The protozoa identified in dogs with splenitis include Neospora caninum, 18 Hepatozoon canis, 3,16 Trypanosoma cruzi, 29 and Leishmania chagasi.…”

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confidence: 99%

Splenitis in 33 Dogs

et al. 2016

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Splenitis is uncommonly reported in dogs. Herein, the authors describe its prevalence, clinical findings and outcomes, histologic patterns, and causes. Splenic samples of dogs diagnosed with splenitis between 2005 and 2013 were collected and stained with hematoxylin and eosin, Gram, green-Gram, Giemsa, periodic acid-Schiff, and Ziehl-Neelsen. Samples were processed for polymerase chain reaction (PCR) to detect bacteria, fungi, and protozoa ( Leishmania infantum, Hepatozoon canis). Thirty-three of 660 splenic samples (5%) had splenitis. Clinical findings and outcomes were available in 19 dogs (58%); 49% had weakness, 33% had fever, and 84% survived. The most frequent inflammatory patterns included purulent splenitis (27%), pyogranulomatous splenitis (24%), and neutrophilic perisplenitis (15%). One dog had a putative diagnosis of primary splenitis; in 8 dogs, microorganisms were identified histologically or by PCR in the spleen without obvious comorbidities. Twenty-four dogs (73%) had concurrent diseases; a permissive role in the development of splenitis was suspected in 21 of these cases. Histologic examination identified the cause of splenitis in 10 dogs. Bacteria were identified by PCR in 23 cases, but the bacteria were confirmed histologically in only 6 of these. Leishmania was detected with PCR in 6 dogs. Leishmania was identified in 1 dog and H. canis in another histologically, but both were PCR negative. Fungi were identified in 8 spleens by PCR and in 1 by histology. This study suggests that splenitis is uncommon in dogs and is frequently associated with systemic diseases. Prognosis is favorable in most cases. Identification of bacteria, fungi, and protozoa in the spleens of affected dogs with PCR should be interpreted cautiously, because the findings are not confirmed histologically in many cases.

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Splenitis in 33 Dogs

et al. 2016

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“…In contrast to S. apiospermum , which is commonly found in soil, sewage and polluted waterways, S. prolificans is more commonly isolated from soil and potted plants and has a more restricted geographical distribution with the majority of cases in humans reported in Australia and Spain [2] . Interestingly, one of the two previously reported cases of disseminated S. prolificans infection in dogs also occurred in Australia [7] , with the other occurring in New York [9] . Scedosporiosis in humans represents a broad spectrum of clinical disease including local cutaneous and subcutaneous infection (eumycetoma) that occur secondary to penetration wounds; saprobic involvement of a previously damaged bronchopulmonary tree; invasive pulmonary disease; sinopulmonary and central nervous system infection associated with near drowning׳s in polluted water ways contaminated with P. boydii ; and disseminated infection.…”

Section: Discussionmentioning

confidence: 94%

“…This is the first report of disseminated mycosis due to S. prolificans in a Labrador retriever dog. Previous reports of disseminated scedosporiosis in dogs have been restricted to German Shepherd dogs (GSD) [5–9] , and were due to S. apiospermum infection [5,6,8] except in one case of S. prolificans infection [7] . There is a single case reported of disseminated S. prolificans (previously S. inflatum ) infection in another breed; a Beagle with osteomyelitis and pulmonary involvement [9] .…”

Section: Discussionmentioning

confidence: 99%

Disseminated Scedosporium prolificans infection in a Labrador retriever with immune mediated haemolytic anaemia

Taylor

Talbot

Bennett

et al. 2014

Medical Mycology Case Reports

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Disseminated scedosporiosis is rare in dogs and is usually reported in German Shepherds with suspected heritable immunodeficiency. This is the first report of disseminated scedosporiosis due to Scedosporium prolificans in a Labrador retriever dog that was receiving immunosuppressive drug therapy for treatment of immune-mediated haemolytic anaemia. Despite cessation of immunosuppressive medications and an initial response to aggressive treatment with voriconazole and terbinafine the dog developed progressive disease with neurological signs necessitating euthanasia six months from diagnosis.

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“…Scedosporium prolificans is an opportunistic fungal pathogen. This case report describes a young female German Shepherd dog that was presented with 3‐week history of polyuria, polydipsia, lethargy, reduced appetite, weight loss and urinary incontinence 6 . She developed a right‐sided head tilt and horizontal nystagmus, which the authors suggested was caused by metronidazole therapy.…”

Section: Small Animalsmentioning

confidence: 98%