Disseminated superficial actinic porokeratosis: A clinical study

Shumack, Stephen; Commens, Chris

doi:10.1016/s0190-9622(89)70126-2

Cited by 56 publications

(38 citation statements)

References 30 publications

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“…Disseminated superficial actinic porokeratosis (DSAP) is the most common form of porokeratosis, and is inherited as an autosomal dominant condition, with reduced penetrance at a younger age1. The characteristic lesions of DSAP represent multiple annular, hyperkeratotic, brownish macules measuring 2~5 mm in diameter.…”

Section: Introductionmentioning

confidence: 99%

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Squamous Cell Carcinoma Developing within Lesions of Disseminated Superficial Actinic Porokeratosis

et al. 2011

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Disseminated superficial actinic porokeratosis (DSAP) consists of multiple annular, hyperkeratotic lesions that have a bilateral distribution on sun-exposed areas, particularly the extremities. DSAPs have a wider distribution than porokeratosis of Mibelli and usually develop during the 3rd or 4th decade of life. Squamous cell carcinoma that arises in the classical type of porokeratosis of Mibelli is well-documented, but there are only a few reports of squamous cell carcinoma in DSAP. Here, we describe a 62-year-old man with DSAP who developed squamous cell carcinoma on his right forearm.

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Section: Introductionmentioning

confidence: 99%

“…The characteristic lesions of DSAP represent multiple annular, hyperkeratotic, brownish macules measuring 2~5 mm in diameter. The center of a macule is minimally atrophic or depressed and the border spreads centrifugally in raised ridges1,2. The distribution is symmetric and usually affects sun-exposed areas.…”

Section: Introductionmentioning

confidence: 99%

Squamous Cell Carcinoma Developing within Lesions of Disseminated Superficial Actinic Porokeratosis

et al. 2011

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“…Disseminated superficial actinic porokeratosis (DSAP; MIM]s 175900 and 607728) is a variant of the different types of porokeratoses [Shumack and Commens, 1989]. The disease is inherited as an autosomal dominant trait and, to date, linkage in various Chinese families was reportedly established at four different chromosomal loci, 12q23.2-q24.1 [Xia et al, 2000], 12q24.1-q24.2 [Wei et al, 2003], 15q25.1-q26.1 [Xia et al, 2002], and 18p11.3 [Wei et al, 2004], respectively.…”

mentioning

confidence: 99%

Lack ofSSH1 mutations in Dutch patients with disseminated superficial actinic porokeratosis: is there really an association?

2007

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“…Its onset is usually in the third or fourth decade of life and involves the sun-exposed skin, but paradoxically, the face is involved in only 15% of cases [2]. DSAP is inherited as an autosomal dominant condition, with reduced penetrance at younger ages.…”

Section: Sirmentioning

confidence: 99%

“…Lesions are typically asymptomatic but some patients may experience pain, pruritus, or cosmetic concerns. Clinically, the characteristic lesion is a crateriform horny papule that gradually extends to form a circinate plaque with a distinct ridge like border and atrophic center, which is histopathologically characterized by cornoid lamella [2].…”

Section: Sirmentioning

confidence: 99%