Dissipation of triclosan, triclocarban, carbamazepine and naproxen in agricultural soil following surface or sub-surface application of dewatered municipal biosolids

Al-Rajab, Abdul Jabbar; Sabourin, Lyne; Lapen, David R.; Topp, Edward

doi:10.1016/j.scitotenv.2015.01.075

Cited by 44 publications

(20 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The soil used in this study was characterized by a low content of organic matter and a high content of the sand fraction, which might result in a lower adsorption of NSAIDs to soil components and a higher availability of drugs for soil microorganisms (Xu et al, 2010; González-Naranjo et al, 2013; Vasiliadou et al, 2013; Estevez et al, 2014; Graouer-Bacart et al, 2016). This effect was also observed in relation to other organic compounds such as pesticides (Karpouzas and Walker, 2000; Liang et al, 2011; Cycoń et al, 2014), polycyclic aromatic hydrocarbons (Sverdrup et al, 2002; Rivas et al, 2008; Chen and Yuan, 2011) and other pharmaceuticals (Topp et al, 2008b; Sabourin et al, 2009; Al-Rajab et al, 2015; Barra Caracciolo et al, 2015). In addition, the observed effect might also be related to the chemical structure and physico-chemical properties of an individual NSAID that determine its toxicity to soil microorganisms (Dastidar et al, 2000; Paje et al, 2002; Lawrence et al, 2007) and the susceptibility to degradation processes (Xu et al, 2009; Al-Rajab et al, 2010; Lin and Gan, 2011; Grossberger et al, 2014; Domaradzka et al, 2015).…”

Section: Discussionmentioning

confidence: 68%

“…Studies by Chefetz et al (2008) proved that both the content and physicochemical nature of soil organic matter (SOM) strongly influenced the sorption of DCF and NPX in SOM-rich soil layers. Pharmaceuticals adsorbed to the organic phase are likely to be far less bioavailable and more persistent than freshly added ones (Al-Rajab et al, 2015). Another mechanism that is responsible for the dissipation of NSAIDs is microbial-mediated degradation (Xu et al, 2009; Carr et al, 2011a,b; Girardi et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

“…It has been observed that DCF, IBF and NPX were quickly degraded (0.2–9.5 days) in soil at a concentration of 0.05 mg/kg soil and significantly longer (68 days) when they were applied at a concentration of 5 mg/kg soil (Grossberger et al, 2014). However, environmental factors such as soil type, temperature and moisture strongly affect the degradation rate of these pharmaceuticals (Topp et al, 2008a; Al-Rajab et al, 2010; Carr et al, 2011b; Al-Rajab et al, 2015). Many authors have reported the ability of microorganisms to degrade NSAIDs.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Variable Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) on Selected Biochemical Processes Mediated by Soil Microorganisms

et al. 2016

View full text Add to dashboard Cite

Non-steroidal anti-inflammatory drugs (NSAIDs) are the most frequently used group of pharmaceuticals. The high consumption and the uncontrolled disposal of unused drugs into municipal waste or their deposit in landfills can result in an increased concentration of these compounds in soils. Moreover, these drugs can affect the microbial activity. However, there is a lack of knowledge about these effects or it is very limited. Therefore, the objective of this study was to compare the impact of selected commercially available NSAIDs, i.e., diclofenac (DCF), naproxen (NPX), ibuprofen (IBF) and ketoprofen (KTP), applied at concentrations of 1 and 10 mg/kg soil, on the activity of soil microorganisms during the 90-day experiment. To ascertain this impact, substrate-induced respiration (SIR), soil enzyme activities, i.e., dehydrogenase (DHA), acid and alkaline phosphatases (PHOS-H and PHOS-OH) and urease (URE) as well as changes in the rates of nitrification and ammonification processes were determined. In addition, the number of culturable bacteria and fungi were enumerated. In general, the obtained data showed a significant stimulatory effect of NSAIDs on the microbial activity. Higher concentrations of NSAIDs caused a greater effect, which was observed for SIR, PHOS-H, PHOS-OH, URE, N-NO3- and N-NH4+, even during the whole incubation period. Moreover, the number of heterotrophic bacteria and fungi increased significantly during the experiment, which was probably a consequence of the evolution of specific microorganisms that were capable of degrading NSAIDs and used them as an additional source of carbon and energy. However, an inhibitory effect of NPX, IBF or KTP for SIR, DHA, on both phosphatases and culturable bacteria and fungi was observed at the beginning of the experiment. At lower concentrations of NSAIDs, in turn, the effects were negligible or transient. In conclusion, the application of NSAIDs altered the biochemical and microbial activity of soil what may cause the disturbance in soil functioning. It is reasonable to assume that some components of the NSAID formulations could stimulate soil microorganisms, thus resulting in an increase in biochemical activities of the soil.

show abstract

Section: Discussionmentioning

confidence: 68%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Variable Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) on Selected Biochemical Processes Mediated by Soil Microorganisms

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Mass balance suggests that 30% of the TCS entering municipal wastewater treatment plants (WWTPs) was adsorbed to and persisted in the sludge, while 5% was still present in the effluent (Bester 2003). Due to its incomplete removal in the WWTPs, TCS can be introduced into the environment following the discharge of effluent and land application of biosolids (Dann and Hontela 2011;Al-Rajab et al, 2015). As a result, TCS is frequently detected at concentrations up to a few g/L in aquatic environments (Bedoux et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Interactions between the antimicrobial agent triclosan and the bloom-forming cyanobacteria Microcystis aeruginosa

Huang

Cheng

et al. 2016

Aquatic Toxicology

View full text Add to dashboard Cite

“…As an endocrine disrupting chemical, it has a negative impact on the environment and human health, especially aquatic ecosystems (Alrajab et al, 2015).…”

mentioning

confidence: 99%

Response mechanisms to joint exposure of triclosan and its chlorinated derivatives on zebrafish (Danio rerio) behavior

et al. 2018

View full text Add to dashboard Cite

h i g h l i g h t sJoint toxicity of triclosan and its main products (TDTs) to zebrafish behavior. TDTs-stress produced larval abnormality and adult anxiety-or autism-like behavior. Behavioral effects focus on social interaction, preference, T-maze tests and so on. Abnormal behavior from changes in the related gene, biomarker and pathological tissue. TDTs produced vascular ablation in head and occurrence of massive apoptosis in brain. a r t i c l e i n f o b s t r a c tTriclosan (TCS), 2,4,6-trichlorophenol (2,4,6-TCP) and 2,4-dichlorophenol (2,4-DCP) frequently co-exist in real-world aquatic environments; the latter two contaminants contributing to TCS photolytic products or chlorinated derivatives. There is a paucity of information regarding their joint toxicity to aquatic organisms leading us to study their effects on the swimming behavior of zebrafish (Danio rerio). Herein, we reported that 0.28 mg/L TDT exposure (mixtures of TCS, 2,4,6-TCP and 2,4-DCP) enhanced 24-hpf embryonic spontaneous movement frequency, 96-hpf larval activity; however, the 0.56 and 1.12 mg/L TDT treatments decreased all of these behavioral endpoints. All adult behavioral tests demonstrated that chronic TDT exposure (0.14 mg/L) led to hyperactivity and restlessness in adult zebrafish. A 0.14 mg/L TD DATE /@ "M/d/yyyy" 11/21/2017T treatment led to anxiety-like behavior in a bottom dwelling test and excessive panic and low hedging capacity in a conditioned place preference test. Social interaction test demonstrated that zebrafish preferred quiet and isolated space in response to TDT stress. Zebrafish memory was significantly decreased in a T-maze experiment. Whole mount in situ hybridization of pax2a and bcl2l11 genes revealed that their differential expression in the brain and skeleton were related to the corresponding phenotypic behavioral abnormality. A series of biomarker and estrogen receptor assays demonstrated that TDT acute exposure caused abnormal energy metabolism and neurological diseases. AO staining revealed that TDT exposure produced vascular ablation in the head, as well as the occurrence of massive apoptosis in the brain. TEM observation showed pyknosis of nucleus following TDT exposure. These results allow assessment of mechanisms for zebrafish abnormal behavior in response to TDT exposure, and are useful for early intervention and gene therapy of contaminant-induced diseases.

show abstract

Dissipation of triclosan, triclocarban, carbamazepine and naproxen in agricultural soil following surface or sub-surface application of dewatered municipal biosolids

Cited by 44 publications

References 31 publications

Variable Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) on Selected Biochemical Processes Mediated by Soil Microorganisms

Variable Effects of Non-steroidal Anti-inflammatory Drugs (NSAIDs) on Selected Biochemical Processes Mediated by Soil Microorganisms

Interactions between the antimicrobial agent triclosan and the bloom-forming cyanobacteria Microcystis aeruginosa

Response mechanisms to joint exposure of triclosan and its chlorinated derivatives on zebrafish (Danio rerio) behavior

Contact Info

Product

Resources

About