Dissociation between increased apoptosis and expression of the tumor necrosis factor-alpha system in term placental villi with preeclampsia

Kharfi, Abdelaziz; Bureau, Marc; Giguère, Yves; Moutquin, Jean‐Marie; Forest, Jean‐Claude

doi:10.1016/j.clinbiochem.2006.01.016

Cited by 11 publications

(4 citation statements)

References 33 publications

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“…Placental TNF could be involved in these processes since hypoxia/re-oxygenation of placental tissues in vitro increased secretion of the cytokine and activation of endothelial cells in a TNF-dependent manner [54]. Although increased apoptosis was also noticed in preeclamptic placentae [152], TNF may not be a primary cause[153]. Stimulation of normal and preeclamptic trophoblasts failed to demonstrate increased programmed cell death but resulted in higher sensitivity of the latter to TNF-induced secretion of tissue factor [154].…”

Section: Function Of the Tnf–tnf Receptor System In Gestational Timentioning

confidence: 99%

Human Tumour Necrosis Factor: Physiological and Pathological Roles in Placenta and Endometrium

Haider¹,

Knöfler²

2009

Placenta

305

221

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The cytokine tumour necrosis factor alpha (TNF) is a well known member of the TNF superfamily consisting of at least 18 ligands and 29 different receptors involved in numerous cellular processes. TNF signals through two distinct receptors TNFR1 and TNFR2 thereby controlling expression of cytokines, immune receptors, proteases, growth factors and cell cycle genes which in turn regulate inflammation, survival, apoptosis, cell migration, proliferation and differentiation. Since expression of TNF was discovered in amnion and placenta many studies demonstrated the presence of the cytokine and its receptors in the diverse human reproductive tissues. Whereas TNF has been implicated in ovulation, corpus luteum formation and luteolysis, this review focuses on the functions of TNF in human placental, endometrial and decidual cell types of normal tissues and also discusses its role in endometrial and gestational diseases. Physiological levels of the cytokine could be important for balancing cell fusion and apoptotic shedding of villous trophoblasts and to limit trophoblast invasion into maternal decidua. Regulation of the TNF/TNFR system by steroid hormones also suggests a role in uterine function including menstrual cycle-dependent destruction and regeneration of endometrial tissue. Aberrant levels of TNF, however, are associated with diverse reproductive diseases such as amniotic infections, recurrent spontaneous abortions, preeclampsia, preterm labour or endometriosis. Hence, concentrations, receptor distribution and length of stimulation determine whether TNF has beneficial or adverse effects on female reproduction and pregnancy.

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Section: Function Of the Tnf–tnf Receptor System In Gestational Timentioning

confidence: 99%

Human Tumour Necrosis Factor: Physiological and Pathological Roles in Placenta and Endometrium

Haider¹,

Knöfler²

2009

Placenta

305

221

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“…Although no changes in the percentage of Ki67 positive cells and M30 positive cells were observed following short term BPA exposure in this study, previous studies have described anti-proliferative and apoptotic effects of BPA on term primary cytotrophoblast or BeWo cells by measuring [3H]-thymidine incorporation or quantifying changes in apoptotic markers, including M30 and tumor-necrosis factor-alpha protein [ 61 , 72 ]. In this study, we quantified Ki67 protein expression using immunostaining, which is a proliferative marker that is expressed in all active phases of the cell cycle (G1, S, G2, and M); we also used an anti-M30 antibody, which is directed against a specific epitope of cytokeratin 18 that is formed by early caspase cleavage in apoptotic cells [ 97 , 98 ]. Additional markers of apoptosis and proliferation should be explored to further investigate the effects of BPA on trophoblast turnover in cultured explants.…”

Section: Discussionmentioning

confidence: 99%

Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placenta

Zou

Harris

Forbes

et al. 2022

Biology of Reproduction

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Bisphenol A (BPA) exposure during pregnancy is associated with low fetal weight, particularly in male fetuses. Expression of estrogen-related receptor gamma (ESRRG), a receptor for BPA in human placenta, is reduced in fetal growth restriction. This study sought to explore whether ESRRG signaling mediates BPA-induced placental dysfunction, and determine whether changes in the ESRRG signaling pathway are sex-specific. Placental villous explants from 18 normal term pregnancies were cultured with a range of BPA concentrations (1 nM-1 μM). Baseline BPA concentrations in the placental tissue used for explant culture ranged from 0.04 nM-5.1 nM (average 2.3 nM ±1.9 nM; n = 6). Expression of ESRRG signalling pathway constituents and cell turnover were quantified. BPA (1 μM) increased ESRRG mRNA expression after 24 hours in both sexes. ESRRG mRNA and protein expression were increased in female placentas treated with 1 μM BPA for 24 hours, but were decreased in male placentas treated with 1 nM or 1 μM for 48 hours. Levels of HSD17B1 and PLAC1, genes downstream of ESRRG, were also affected. HSD17B1 mRNA expression was increased in female placentas by 1 μM BPA; however, 1 nM BPA reduced HSD17B1 and PLAC1 expression in male placentas at 48 hours. BPA treatment did not affect rates of proliferation, apoptosis or syncytiotrophoblast differentiation in cultured villous explants. This study has demonstrated that BPA affects the ESRRG signalling pathway in a sex-specific manner in human placentas and a possible biological mechanism to explain the differential effects of BPA exposure on male and female fetuses observed in epidemiological studies.

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“…On the other hand, our results showed that high levels of vitamins C and E, separately or in combination, were able to induce an increase in the production of TNF‐α at the level of protein and mRNA. This major proinflammatory cytokine is in the center of innumerable physiological and pathophysiological processes related to healthy 3,23 and complicated pregnancy 24 . TNF‐α seems to be necessary to fetal development, because it is expressed in normal tissues of various organs during gestation.…”

Section: Discussionmentioning

confidence: 99%

“…It has been shown to regulate progesterone, estradiol and hCG production in placental fragments, JEG‐3 cells (placental choriocarcinoma) or purified cytotrophoblasts, 25 suggesting its implication in trophoblast differentiation and function. TNF‐α is also involved in apoptosis and turnover of trophoblast, 24,26 and in vascular reactivity by enhancing response to vasoconstrictor molecules such as endothelin 27 or impairing response to vasodilatator molecules such as acetylcholine 28,29 . Therefore, any abnormal production of TNF‐α during pregnancy, in maternal circulation and/or in feto‐placental unit, could lead to adverse pregnancy outcomes such as abortion, intrauterine growth restriction or preeclampsia 30 …”

Section: Discussionmentioning

confidence: 99%

Detrimental effects of high levels of antioxidant vitamins C and E on placental function: Considerations for the Vitamins in Preeclampsia (VIP) trial

Aris

Leblanc

Ouellet

et al. 2008

J of Obstet and Gynaecol

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Dissociation between increased apoptosis and expression of the tumor necrosis factor-alpha system in term placental villi with preeclampsia

Cited by 11 publications

References 33 publications

Human Tumour Necrosis Factor: Physiological and Pathological Roles in Placenta and Endometrium

Human Tumour Necrosis Factor: Physiological and Pathological Roles in Placenta and Endometrium

Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placenta

Detrimental effects of high levels of antioxidant vitamins C and E on placental function: Considerations for the Vitamins in Preeclampsia (VIP) trial

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