Dissolution behavior of the bioactive glass S53P4 when sodium is replaced by potassium, and calcium with magnesium or strontium

Hupa, Leena; Fagerlund, Susanne; Massera, Jonathan; Björkvik, Leena

doi:10.1016/j.jnoncrysol.2015.03.026

Cited by 36 publications

(25 citation statements)

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“…Additionally, the increase in solubility as a function of strontium content was accompanied by a linear increase in the amount of strontium released in solution. While these results are consistent with published data on bioactive strontium-containing silicate or phosphate-based glasses 1, 25, 26, 59, 60 , work by Goel et al . reported that strontium additions led to a decrease in the chemical degradation of CaO-MgO-SrO-SiO 2 -P 2 O 5 -CaF 2 glasses 39 .…”

Section: Discussionsupporting

confidence: 93%

Strontium‐releasing fluorapatite glass‐ceramics: Crystallization behavior, microstructure, and solubility

et al. 2017

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The purpose of this work was to investigate the effect of strontium partial replacement for calcium on the crystallization behavior, microstructure and solubility of fluorapatite glass-ceramics. Four glass compositions were prepared with increasing amounts of strontium partially replacing calcium. The crystallization behavior was analyzed by differential scanning calorimetry and X-ray diffraction (XRD). The microstructure was investigated by scanning electron microscopy. The chemical solubility was quantified according to ISO standard 10993-14. The amount of strontium released in solution after incubation in TRIS-HCl or citric acid buffer was measured by atomic absorption spectroscopy. XRD analyses revealed that partially substituted strontium-fluorapatite and strontium-åkermanite crystallized after strontium additions. The lattice cell volume of both phases increased linearly with the amount of strontium in the composition. Strontium additions led to a reduction in crystal size and an increase in crystal number density. The chemical solubility and amount of strontium released in solution increased linearly with the amount of strontium present in the composition in both TRIS-HCl and citric acid buffers. Total amounts of strontium released reached a maximum of 547 ± 80 ppm in TRIS-HCl and 1252 ± 290 ppm in citric acid buffer for the glass composition with the highest amount of strontium. For all strontium-containing compositions, the amount released in TRIS-HCl continued to increase between 70 and 120 h, indicating sustained release rather than burst release. © 2017 Wiley Periodicals, Inc. J Biomater Res Part B: 106B: 1421-1430, 2018.

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Section: Discussionsupporting

confidence: 93%

Strontium‐releasing fluorapatite glass‐ceramics: Crystallization behavior, microstructure, and solubility

et al. 2017

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“…Calcium containing bio‐glasses for bone regeneration are devised to dissolve under biological conditions and produce hydroxyapatite. Strontium has been added to calcium bioglasses to control its dissolution rate, which might lead to improvements in bone regeneration . In addition, low concentrations of strontium bring other properties of clinical interest to the biomaterial.…”

Section: Introductionmentioning

confidence: 99%

“…The MMIE effect can be used to adjust the dissolution properties of the glass, controlling the type and concentration of chemical species. For this reason, the fundamental understanding of the bonding of cations of relevance in bioglasses, such as Na + , Ca 2+ , and Sr 2+ , is an important step to assist in the design of bioactive materials with specific ion dissolution rates . Some fundamental questions in mixed alkali/alkaline earth phosphates are, for instance, up to which extent Ca/Sr substitutions are isomorphic, where do the strong and weak cations locate in complex phosphate networks, is the mixture of the cations strictly randomic, and how the cation replacement influences the medium range order of the network.…”

Section: Introductionmentioning

confidence: 99%

“…Strontium has been added to calcium bioglasses to control its dissolution rate, which might lead to improvements in bone regeneration. [9][10][11][12][13][14][15] In addition, low concentrations of strontium bring other properties of clinical interest to the biomaterial. Strontium acts as an antibacterial species in bone and dental bioglass, [16][17][18][19][20] and also increases X-ray opacity in implants, improving contrast in radiological imaging.…”

Section: Introductionmentioning

confidence: 99%

“…For this reason, the fundamental understanding of the bonding of cations of relevance in bioglasses, such as Na + , Ca 2+ , and Sr 2+ , is an important step to assist in the design of bioactive materials with specific ion dissolution rates. 13,[32][33][34] Some fundamental questions in mixed alkali/alkaline earth phosphates are, for instance, up to which extent Ca/Sr substitutions are isomorphic, where do the strong and weak cations locate in complex phosphate networks, is the mixture of the cations strictly randomic, and how the cation replacement influences the medium range order of the network. Some research done on Na-Sr and Na-Ca polyphosphates indicate that there are definite bonding preferences for Na and the alkaline earths in relation with the two types of phosphate tetrahedra in the network * .…”

Section: Introductionmentioning

confidence: 99%

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Bonding of alkaline and alkaline earth cations in Na‐Ca‐Sr polyphosphate glasses

Morguetto

Tsunaki

Schneider

2019

Int J of Appl Glass Sci

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Dissolution of phosphates bioglasses, for bone regeneration or controlled ion release, is a key property to be tuned by adequate selection of chemical species. Mixed Na‐Sr and Na‐Ca polyphosphate glasses exhibit definite bonding preferences of the stronger cations to O from chain‐end phosphates (Q1) instead of random bonding to the network (Q1 and Q2). This behavior is important for the control of dissolution, as hydration starts from the reaction of H with O in Q1. To analyze this bonding preference in glasses with two alkaline earths competing for O, mixed Na‐Ca‐Sr polyphosphates (0.57‐x) Na2O·x/2 SrO·x/2 CaO·0.43 P2O5 (0 ≤ x ≤ 0.30 molar fraction) were considered. 31P nuclear magnetic resonance was used to analyze the short‐range environments of Qn groups, detecting preferential bonding of Ca and Sr to Q1. To probe variations in the medium‐range organization of the network induced by Ca or Sr, glasses with compositions (0.57‐x) Na2O·x MO·0.43 P2O5 (M = Ca,Sr; 0 ≤ x≤0.30 molar fraction), were analyzed using 31P‐double‐quantum techniques. An increase in mutual Q2 self‐connectivity relative to the base Na‐polyphosphate network was detected as Ca or Sr were added, indicating conversion of linear phosphate chains into rings.

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Bioactive GlassS53P4 – From a Statistically Suggested Composition to Clinical Success

Hupa¹,

Lindfors²

2022

Bioactive Glasses and Glass‐Ceramics

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Dissolution behavior of the bioactive glass S53P4 when sodium is replaced by potassium, and calcium with magnesium or strontium

Cited by 36 publications

References 36 publications

Strontium‐releasing fluorapatite glass‐ceramics: Crystallization behavior, microstructure, and solubility

Strontium‐releasing fluorapatite glass‐ceramics: Crystallization behavior, microstructure, and solubility

Bonding of alkaline and alkaline earth cations in Na‐Ca‐Sr polyphosphate glasses

Bioactive GlassS53P4 – From a Statistically Suggested Composition to Clinical Success

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