Distalization rate of maxillary canines in an alveolus filled with leukocyte-platelet–rich fibrin in adults: A randomized controlled clinical split-mouth trial

Pacheco, Ariel Adriano Reyes; Collins, Jim; Contreras, Nelsida; Lantigua, Astrid; Pithon, Matheus Melo; Tanaka, Orlando Motohiro

doi:10.1016/j.ajodo.2020.03.020

“…[14] revealed an increased rate of canine retraction when placing L-PRF clot in the extraction sites. Upon moving the maxillary canines in the premolars extraction sites that were preserved with L-PRF membranes, Pacheco et al Palatal 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) 0 (0) [38] found a decreased rate of retraction in 15 out of 17 patients (88%); only two subjects had greater retraction on the experimental side. The conflicting results may be related to different centrifugation protocols and methodology.…”

Section: Discussionmentioning

confidence: 99%

Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial

Zeitounlouian

¹

,

Zeno

²

,

Brad

³

et al. 2021

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Background The role of injectable platelet rich fibrin (i-PRF) in orthodontic treatment has not been investigated with focus on its effect on dental and bony periodontal elements. Objective To evaluate the efficacy of i-PRF in bone preservation and prevention of root resorption. Methods A randomized split-mouth controlled trial included 21 patients aged 16–28 years (20.85 ± 3.85), who were treated for Class II malocclusion with the extraction of the maxillary first premolars. Right and left sides were randomly allocated to either experimental treated with i-PRF or control sides. After the leveling and alignment phase, the canines were retracted with 150gm forces. The i-PRF was prepared from the blood of each patient following a precise protocol, then injected immediately before canine retraction on the buccal and palatal aspects of the extraction sites. Localized maxillary cone beam computed tomography scans were taken before and after canine retraction to measure alveolar bone height and thickness and canine root length (indicative of root resorption), and the presence of dehiscence and fenestration. Paired sample t-tests and Wilcoxon signed rank tests were used to compare the changes between groups. Results No statistically significant differences in bone height, bone thickness were found between sides and between pre- and post-retraction period. However, root length was reduced post retraction but did not differ between sides. In both groups, postoperative dehiscence was observed buccally and palatally and fenestrations were recorded on only the buccal aspect. Conclusions I-PRF did not affect bone quality during canine retraction or prevent canine root resorption. I-PRF did not reduce the prevalence of dehiscence and fenestration. Trial registration ClinicalTrials.gov (identifier number: NCT 03399760. 16/01/2018).

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“…[21][22][23][24] Two studies were carried out over a period of 5 months. [25,26] e studies by El-Timamy et al and Tehranchi et al were carried out over 4 months. [27,28] e study by Nemtoi et al was carried out for 6 months.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…[16] Four out of the nine studies included iPRF, [21,23,24,26] two studies used iPRP, [22,27] and the remaining used LPRF membrane and PRF plugs as intervention. [16,25,28] In the studies using i-PRP, the administration was done at 0, 3, and 6 weeks by El-Timamy et al [27] and only once before retraction by Ali et al, [22] Erdur et al, and Karakasli et al administered PRF twice immediately after extraction of premolar teeth and during the 2 nd week of distalization. [21,23] Zeitounlouian et al administered i-PRF twice, just before refraction and 4 weeks later.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…[21,23] Zeitounlouian et al administered i-PRF twice, just before refraction and 4 weeks later. [26] Karci et al administered i-PRF only once before canine distalization [24] and in the studies by [16,25,28] All included studies reported on the amount of canine distal movement except the study by Karakasli et al, in which incisor distal movement was measured. Canine rotation was reported in three studies, [23,26,27] molar mesialization in two studies, [24,26] and the study by El-Timamy et al reported pain scores.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…e RoB in the included studies is summarized in [Figure 2]. On overall assessment, two studies presented with a high RoB [16,25] six had some concerns [21][22][23][24]26,28] and only one study had a low RoB. [27] For bias due to the randomization process four studies had some concerns, [21][22][23]26] one study reported high RoB as the method used for random sequence generation was not described, [16] and four studies had a low RoB.…”

Section: Rob Assessment Of Included Studiesmentioning

confidence: 99%

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Platelet-rich derivatives for accelerating the rate of orthodontic tooth movement - a systematic review and meta-analysis

Katyal

¹

,

George

²

,

Jain

³

et al. 2022

APOS

0

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Objective: The aim of this systematic review and meta-analysis was to report on the effects of using platelet-rich derivatives on the rate of tooth movement. Material and Methods: Both electronic and manual searches were performed with specific eligibility criteria based on population, intervention, comparison, outcome, and study design. Risk of bias (RoB) assessment was done using the Cochrane RoB tool 2, the data were pooled and analyzed using review manager 4.5, and certainty of the evidence was assessed using the Grading of Recommendations Assessment, Development, and Evaluation approach. Two independent reviewers performed the study selection, data extraction, and analysis. Nine studies were included for qualitative analysis and two of them were subjected to meta-analysis. Results: The standard mean difference for the rate of canine distal movement with platelet-rich derivatives was not significantly higher than controls at any of the time intervals (P > 0.0001). Rotation of canines, molar mesialization, and pain scores were not affected by the administration of platelet-rich derivatives for accelerating tooth movement. A moderate to high RoB was noted in the included studies and the certainty of the available evidence as assessed by the GRADE approach was moderate. Conclusion: The included studies presented with high heterogeneity and more high-quality studies with strict protocols are needed. Even though individual studies report significant acceleration of tooth movement following administration of PR derivatives, moderate certainty of evidence suggests no acceleratory effect on tooth movement.

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Effect of leukocyte-platelet-rich fibrin (L-PRF) on the rate of orthodontic tooth movement and expression of various biomarkers in gingival crevicular fluid

Krishna

¹

,

Duggal

²

,

Sharan

³

et al. 2023

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Objectives To assess the outcome of leukocyte-platelet-rich fibrin (L-PRF) on the rate of maxillary canine retraction and its correlation with the levels of Receptor activator of nuclear factor kappa-B ligand (RANKL), osteoprotegerin (OPG), and RANKL:OPG in the gingival crevicular fluid (GCF) during comprehensive orthodontic treatment. Subjects and methods Eighteen females who required all 1st premolars extraction for the correction of their class I bimaxillary protrusion malocclusions were included. The L-PRF plugs were placed in the experimental side 1st premolar extraction sockets. Canine retraction was performed by sliding mechanics. Canine retraction was assessed from the maxillary study models prepared just before the extraction ( T 0 ) and then at 1 week ( T 1 ), 2 weeks ( T 2 ), 4 weeks ( T 3 ), and 8 weeks ( T 4 ) after the 1st premolar extraction and placement of L-PRF plugs. T he concentrations of RANKL and OPG in the GCF were evaluated at T 0 , T 1 , T 2 , T 3 , and T 4 . Results In experimental sides, the amount of canine retraction was statistically more during the T 0 – T 1 , T 1 – T 2 , and T 2 – T 3 periods. The mean concentration of RANKL at T 1 , T 2 , and T 3 was significantly more in the experimental sides. The mean concentration of OPG was significantly less in the experimental sides at T 2 , T 3 , and T 4 . The RANKL:OPG was significantly more in the experimental sides at T 1 , T 2 , T 3 , and T 4 . No significant correlation was found between amount of canine retraction and concentration of RANKL and OPG and RANKL to OPG ratio in GCF. Conclusions The L-PRF accelerated the rate of maxillary canine retraction by 0.28 mm over an 8-week period. The L-PRF favored the local osteoclastogenesis by enhancing the RANKL and suppressing the OPG concentrations. There was no significant correlation betw...

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Distalization rate of maxillary canines in an alveolus filled with leukocyte-platelet–rich fibrin in adults: A randomized controlled clinical split-mouth trial

Cited by 21 publications

References 41 publications

Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial

Three-dimensional evaluation of the effects of injectable platelet rich fibrin (i-PRF) on alveolar bone and root length during orthodontic treatment: a randomized split mouth trial

Platelet-rich derivatives for accelerating the rate of orthodontic tooth movement - a systematic review and meta-analysis

Effect of leukocyte-platelet-rich fibrin (L-PRF) on the rate of orthodontic tooth movement and expression of various biomarkers in gingival crevicular fluid

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