Distinct demographic profile and molecular markers of primary CNS tumor in 1873 adolescent and young adult patient population

Vadgaonkar, Rohit Avinash; Epari, Sridhar; Chinnaswamy, Girish; Krishnatry, Rahul; Tonse, Raees; Gupta, Tejpal; Jalali, Rakesh

doi:10.1007/s00381-018-3785-y

Cited by 3 publications

(1 citation statement)

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“…In spite of the progress made in the treatment of GBM in recent years (including surgery, radiotherapy, chemotherapy and targeted therapy), the overall prognosis is still not ideal and the long-term survival rate is low. Certain studies indicated that teenagers and young adults account for 27% of all PCNS tumor cases and the average age was 29 years ( 1 , 3 ). If patients are diagnosed with cancer in those busy years of their life, this may take a serious toll on both their body and mind, and in turn on their spouses and offspring ( 4 ).…”

Section: Introductionmentioning

confidence: 99%

Hedgehog signaling regulates the development and treatment of glioblastoma (Review)

et al. 2022

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Glioblastoma (GBM) is the most common and fatal malignant tumor type of the central nervous system. GBM affects public health and it is important to identify biomarkers to improve diagnosis, reduce drug resistance and improve prognosis (e.g., personalized targeted therapies). Hedgehog (HH) signaling has an important role in embryonic development, tissue regeneration and stem cell renewal. A large amount of evidence indicates that both normative and non-normative HH signals have an important role in GBM. The present study reviewed the role of the HH signaling pathway in the occurrence and progression of GBM. Furthermore, the effectiveness of drugs that target different components of the HH pathway was also examined. The HH pathway has an important role in reversing drug resistance after GBM conventional treatment. The present review highlighted the relevance of HH signaling in GBM and outlined that this pathway has a key role in the occurrence, development and treatment of GBM. Contents 1. Introduction 2. Overview of GBM 3. The HH signaling pathway 4. Molecular mechanisms of the HH signaling pathway in GBM 5. Targeting the HH signaling pathway in GBM 6. HH pathway and immunotherapy 7. Discussion 8. Conclusion

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Section: Introductionmentioning

confidence: 99%

Hedgehog signaling regulates the development and treatment of glioblastoma (Review)

et al. 2022

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Negative prognostic impact of epidermal growth factor receptor copy number gain in young adults with isocitrate dehydrogenase wild-type glioblastoma

et al. 2019

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Clinical Audit of Survival Outcomes and Prognostic Factors in Adolescents and Adults with Medulloblastoma

Patil

Gupta

Maitre

et al. 2022

Journal of Adolescent and Young Adult Oncology

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Distinct demographic profile and molecular markers of primary CNS tumor in 1873 adolescent and young adult patient population

Abstract: This is among the few studies reporting spectrum of PCNS tumor in AYA population with distinct tumor subtypes and molecular profiles. AYA patient populations may need special attention with appropriately designed clinical trials.

Cited by 3 publications

References 16 publications

Hedgehog signaling regulates the development and treatment of glioblastoma (Review)

Hedgehog signaling regulates the development and treatment of glioblastoma (Review)

Negative prognostic impact of epidermal growth factor receptor copy number gain in young adults with isocitrate dehydrogenase wild-type glioblastoma

Clinical Audit of Survival Outcomes and Prognostic Factors in Adolescents and Adults with Medulloblastoma

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