Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion of<i>Lactobacillus plantarum</i>WCFS1 to gut epithelial cells

Kong, Chunli; Akkerman, Renate; Klostermann, C.E.; Beukema, Martin; Oerlemans, Marjolein M. P.; Schols, Henk A.; Vos, Paul de

doi:10.1039/d1fo02563e

Cited by 22 publications

(13 citation statements)

References 60 publications

(87 reference statements)

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“…The effects of probiotics on the bacterial composition of the gut of healthy animals have also been relatively poorly studied. However, there have been studies that show the effectiveness of the use of probiotic supplements for preventive purposes [ 20 , 21 , 22 , 23 ]. For example, Yang et al showed that the combination of Cochlearius cochlearium and L. acidophilus has beneficial effects on body weight control and glucose homeostasis in high-fat DIO mice [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Dynamics of Changes in the Gut Microbiota of Healthy Mice Fed with Lactic Acid Bacteria and Bifidobacteria

et al. 2022

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Probiotics are living microorganisms that provide numerous health benefits for their host. Probiotics have various effects on the body; for example, they change gut microbiota, improve the integrity of the epithelial barrier and have anti-inflammatory effects. The use of probiotic supplements that are based on lactic acid bacteria and bifidobacteria is one of the approaches that are used to balance gut microflora. In our study, we evaluated the effects of supplements, which were based on members of the Lactobacillaceae family and bifidobacteria, on the gut microbiome of healthy mice using the 16S rRNA sequencing method. The data that were obtained demonstrated that when mice received the probiotic supplements, statistically significant changes occurred in the composition of the microbiome at the phylum level, which were characterized by an increase in the number of Actinobacteriota, Bacteroidota, Verrucomicrobia and Proteobacteria, all of which have potentially positive effects on health. At the generic level, a decrease in the abundance of members of the Nocardioides, Helicobacter and Mucispirillum genus, which are involved in inflammatory processes, was observed for the group of mice that was fed with lactic acid bacteria. For the group of mice that was fed with bifidobacteria, a decrease was seen in the number of members of the Tyzzerella and Akkermansia genus. The results of our study contribute to the understanding of changes in the gut microbiota of healthy mice under the influence of probiotics. It was shown that probiotics that are based on members of the Lactobacillaceae family have a more positive effect on the gut microbiome than probiotics that are based on bifidobacteria.

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Section: Introductionmentioning

confidence: 99%

Dynamics of Changes in the Gut Microbiota of Healthy Mice Fed with Lactic Acid Bacteria and Bifidobacteria

et al. 2022

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Section: Discussionmentioning

confidence: 99%

“…65 In the case of inulin, for example, fermentation of inulin increases the ability of lactobacilli to adhere, and this selection for specific functions of lactobacilli may be associated with an increased prevalence of some differential COGs. 66 Lactobacilli associated with vegetarian diets showed a higher prevalence of genes with the highest number of differ-ential COGs in the [L] category, which includes DNA polymerase, DNA methylase and DNA methyltransferase. DNA methylation is widespread in bacteria and is a potent type of bacterial gene regulation that protects the host genome from damage.…”

Section: Food and Function Papermentioning

confidence: 99%

Compositional and functional features of the intestinal lactobacilli associated with different long-term diet types

Zhang

Yin

et al. 2023

Food Funct.

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“…Fucosylated and nonfucosylated neutral HMOs yielded more lactate, as compared to the sialylated HMOs . Lacto- N -triaose II specifically induced succinic acid production, and succinic acid triggered anti-inflammatory immune reactions …”

Section: Hmos Modulate Gut Microbiota and Produce Intestinal Metabolitesmentioning

confidence: 96%

“…208 Lacto-N-triaose II specifically induced succinic acid production, and succinic acid triggered anti-inflammatory immune reactions. 209…”

Section: ■ Hmos Modulate Gut Microbiota and Produce Intestinal Metabo...mentioning

confidence: 99%

Current Advances in Structure–Function Relationships and Dose-Dependent Effects of Human Milk Oligosaccharides

Wang

Chen

Wang

et al. 2022

J. Agric. Food Chem.

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HMOs (human milk oligosaccharides) are the third most important nutrient in breast milk. As complex glycans, HMOs play an important role in regulating neonatal intestinal immunity, resisting viral and bacterial infections, displaying antiinflammatory characteristics, and promoting brain development. Although there have been some previous reports of HMOs, a detailed literature review summarizing the structure−activity relationships and dose-dependent effects of HMOs is lacking. Hence, after introducing the structures and synthetic pathways of HMOs, this review summarizes and categorizes identified structure− function relationships of HMOs. Differential mechanisms of different structural HMOs utilization by microorganisms are summarized. This review also emphasizes the recent advances in the interactions between different health benefits and the variance of dosage effect based on in vitro cell tests, animal experiments, and human intervention studies. The potential relationships between the chemical structure, the dosage selection, and the physiological properties of HMOs as functional foods are vital for further understanding of HMOs and their future applications.

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Distinct fermentation of human milk oligosaccharides 3-FL and LNT2 and GOS/inulin by infant gut microbiota and impact on adhesion ofLactobacillus plantarumWCFS1 to gut epithelial cells

Abstract: Fermentation of hMOs 3-FL and LNT2 by infant gut microbiota is structure dependent and different from the commonly applied GOS/inulin, and the fermentation digesta may lead to differential potencies to stimulate the commensal bacteria colonizaiton.

Cited by 22 publications

References 60 publications

Dynamics of Changes in the Gut Microbiota of Healthy Mice Fed with Lactic Acid Bacteria and Bifidobacteria

Dynamics of Changes in the Gut Microbiota of Healthy Mice Fed with Lactic Acid Bacteria and Bifidobacteria

Compositional and functional features of the intestinal lactobacilli associated with different long-term diet types

Current Advances in Structure–Function Relationships and Dose-Dependent Effects of Human Milk Oligosaccharides

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