2020
DOI: 10.1093/ajcn/nqaa195
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Distinct infrastructure of lipid networks in visceral and subcutaneous adipose tissues in overweight humans

Abstract: Background Adipose tissue plays important roles in health and disease. Given the unique association of visceral adipose tissue with obesity-related metabolic diseases, the distribution of lipids between the major fat depots located in subcutaneous and visceral regions may shed new light on adipose tissue–specific roles in systemic metabolic perturbations. Objective We sought to characterize the lipid networks and unveil diffe… Show more

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Cited by 12 publications
(7 citation statements)
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“…Specific roles in adipose biology have been inferred for the seven gene loci studied in detail (Table 1) [3,5,29,40,45,[51][52][53][54][55][56][57]. Remarkably, four of these genes, CABLES1, PEMT, PC, and FAM13A, had one or more of their Tier-1 SNPs near an alternate tissuespecific TSS.…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…Specific roles in adipose biology have been inferred for the seven gene loci studied in detail (Table 1) [3,5,29,40,45,[51][52][53][54][55][56][57]. Remarkably, four of these genes, CABLES1, PEMT, PC, and FAM13A, had one or more of their Tier-1 SNPs near an alternate tissuespecific TSS.…”
Section: Discussionmentioning
confidence: 96%
“…Nonetheless, expansion of SAT depots may also contribute to health either in its protective role or through its interactions with VAT depots [3,5].…”
Section: Introductionmentioning
confidence: 99%
“…Thus, these candidates for regulatory SNPs are likely to be relevant to obesity-related disease susceptibility (3). Specific roles in adipose biology have been inferred for the seven gene loci associated with these SNPs (3,5,25,39,44,(52)(53)(54)(55)(56)(57)(58). Remarkably, four of these genes, CABLES1, PEMT, PC, and FAM13A, had one or more of their Tier-1 SNPs near an alternate tissue-specific TSS.…”
Section: Discussionmentioning
confidence: 99%
“…Pre-menopausal women with their tendency to high SAT/VAT ratios are at lower risk of adipose-related disease (4). Nonetheless, expansion of SAT depots may also contribute to health either in its protective role or through its interactions with VAT depots (3,5).…”
Section: Introductionmentioning
confidence: 99%
“… 24 , 25 , 26 While ceramides are implicated in metabolic syndrome, the distribution of ceramide/dihydroceramide species between subcutaneous and visceral adipose tissue in relation to status of diabetes and gender has not been thoroughly investigated. Subcutaneous and visceral adipose tissue differ in their anatomical, metabolic, and inflammatory characteristics, 27 , 28 , 29 with visceral adiposity being strongly associated with metabolic disease. 28 Data indicate sex differences in the accumulation of adipose tissue and in the regulation of adipose tissue metabolism.…”
Section: Introductionmentioning
confidence: 99%