2023
DOI: 10.1021/acsptsci.3c00028
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Distinct Metabolomic Profiling of Serum Samples from High-Fat-Diet-Induced Insulin-Resistant Mice

Abstract: High-fat-diet (HFD)-induced obesity is associated with an elevated risk of insulin resistance (IR), which may precede the onset of type 2 diabetes mellitus and associated metabolic complications. Being a heterogeneous metabolic condition, it is pertinent to understand the metabolites and metabolic pathways that are altered during the development and progression of IR toward T2DM. Serum samples were collected from C57BL/6J mice fed with HFD or chow diet (CD) for 16 weeks. Collected samples were analyzed by gas … Show more

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Cited by 9 publications
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“…For serum metabolic analysis, 50 µl serum samples was used and extraction procedure similar to bone samples was applied by adding ribitol as internal standard followed by procedures as stated before ( 26 , 27 ). As part of the pre-processing, MS-Dial version 4.80 was utilized to pick peaks, align, annotate, and deconvolute the mass spectra acquired by GC-MS/MS.…”
Section: Methodsmentioning
confidence: 99%
“…For serum metabolic analysis, 50 µl serum samples was used and extraction procedure similar to bone samples was applied by adding ribitol as internal standard followed by procedures as stated before ( 26 , 27 ). As part of the pre-processing, MS-Dial version 4.80 was utilized to pick peaks, align, annotate, and deconvolute the mass spectra acquired by GC-MS/MS.…”
Section: Methodsmentioning
confidence: 99%