2001
DOI: 10.4049/jimmunol.166.11.6795
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Distinct Roles for PECAM-1, ICAM-1, and VCAM-1 in Recruitment of Neutrophils and Eosinophils to the Cornea in Ocular Onchocerciasis (River Blindness)

Abstract: Infiltration of granulocytes into the transparent mammalian cornea can result in loss of corneal clarity and severe visual impairment. Since the cornea is an avascular tissue, recruitment of granulocytes such as neutrophils and eosinophils into the corneal stroma is initiated from peripheral (limbal) vessels. To determine the role of vascular adhesion molecules in this process, expression of platelet endothelial cell adhesion molecule 1 (PECAM-1), ICAM-1, and VCAM-1 on limbal vessels was determined in a murine… Show more

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Cited by 52 publications
(40 citation statements)
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“…109,111 Neutrophils are recruited from the limbal vessels via release of CXC chemokines such as CXCL1 and CXCL2 and upregulation of vascular adhesion molecules such as PECAM-1. 113,114 Eosinophil infiltration occurs later in the disease but aggravates the inflammatory response. 106,[114][115][116] However, neutrophil involvement is thought to be the driving factor behind the progressive corneal haze seen in onchocerciasis.…”
Section: Onchocerca Volvulus (Onchocerciasis) Onchocerciasis Is Due Tmentioning
confidence: 99%
See 1 more Smart Citation
“…109,111 Neutrophils are recruited from the limbal vessels via release of CXC chemokines such as CXCL1 and CXCL2 and upregulation of vascular adhesion molecules such as PECAM-1. 113,114 Eosinophil infiltration occurs later in the disease but aggravates the inflammatory response. 106,[114][115][116] However, neutrophil involvement is thought to be the driving factor behind the progressive corneal haze seen in onchocerciasis.…”
Section: Onchocerca Volvulus (Onchocerciasis) Onchocerciasis Is Due Tmentioning
confidence: 99%
“…113,114 Eosinophil infiltration occurs later in the disease but aggravates the inflammatory response. 106,[114][115][116] However, neutrophil involvement is thought to be the driving factor behind the progressive corneal haze seen in onchocerciasis. 116 Fungi The most common agents in fungal infection are Fusarium spp.…”
Section: Onchocerca Volvulus (Onchocerciasis) Onchocerciasis Is Due Tmentioning
confidence: 99%
“…62 The early inflammatory cellular infiltrate is composed of neutrophils, however; eosinophils are the most prominent inflammatory cells when inflammation peaks. 63,64 In addition, recruitment of neutrophils and eosinophils to the cornea is antibody dependent, with PECAM-1 and ICAM-1 playing important roles. 65 Also, sensitized CD4 þ T cells expressing IL-4 and IL-5 and but not IFN-g cells have been shown to play a role in the keratitis noted after injection with O. volvulus antigen.…”
Section: Corneal Defenses To Infectionmentioning
confidence: 99%
“…Although neutrophils and eosinophils mediate corneal pathology that is similar in appearance, these cell types differ both in the molecular basis of recruitment to the cornea and in the cytotoxic mediators produced. For example, neutrophil infiltration is dependent on expression of platelet endothelial cell adhesion molecule-1 and expression of CXCR2, whereas eosinophil recruitment to the cornea is dependent on expression of Pselectin and ICAM-1, and is regulated by CD4 ϩ cells (23)(24)(25)(26) and by eotaxin (53). These studies also demonstrated that complete inhibition of corneal pathology depends on blocking infiltration of both cell types to the cornea.…”
mentioning
confidence: 82%