Crosstalk between high speed parallel bus signals is one of the most important signal integrity(SI) issues. In this article, a crosstalk simulation method based on full-wave scattering parameters extraction for transmission lines is researched. First, the coupling mechanism between transmission lines is analyzed using S-Parameter network theory and a fast frequency-domain method for crosstalk calculation is introduced. Then based on this method, some basic rules of crosstalk are studied in details and the method is validated by simulation results which agree well with those of RLGC model. At the end of this paper, a practical crosstalk simulation example between high speed data bus signals on a 8-layered printed circuit board is demonstrated step by step.