Distribution and clinical features of Paragonimiasis skrjabini in Three Gorges Reservoir Region

Zhang, Xilin; Wang, Ying; Wang, Guangxi; Chen, Wenbi; Xie, He; Niu, Hongyu; Zhen-lian, LI; Chen, Lin; Wang, Lifang

doi:10.1016/j.parint.2012.06.007

Cited by 27 publications

(26 citation statements)

References 6 publications

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“…One study showed that 39.6% of freshwater crabs in Three Gorge Reservoir Region were infected with P metacercariae. [7] This result implies that an increased awareness of paragonimiasis is necessary in children with clinical symptoms, even in those from cities or denying freshwater crab consumption.…”

Section: Discussionmentioning

confidence: 99%

“…[5,7] We analyzed the records of patients diagnosed with paragonimiasis between May 2005 and May 2016 in the Department of Pediatric Infectious Disease, West China Second Hospital, Sichuan University (Chengdu, China). This tertiary-care, university-affiliated hospital for women and children serves 20,000 children inpatients from Southwest China annually, providing treatment for severe diseases, in addition to referral, consultation, and other large clinical work for women and children from Sichuan Province, as well as Southwest China.…”

Section: Methodsmentioning

confidence: 99%

“…[3,5,6] Meanwhile, paragonimiasis is prevalent in most of the Sichuan basin, especially in the eastern part of Sichuan province and Chongqing city. [5,7] …”

Section: Introductionmentioning

confidence: 99%

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Paragonimiasis in Children in Southwest China

et al. 2017

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Background:Paragonimiasis infection has no specific symptoms or typical radiologic findings, leading to the possibility of misdiagnosis. Thus, the objective of this study was to analyze clinical and radiological features, and treatment outcome of paragonimiasis in children in Southwest China to improve the awareness of this disease.Methods:We retrospectively reviewed the records of children diagnosed with paragonimiasis in West China Second University Hospital between 2005 and 2016. The confirmed diagnosis of paragonimiasis was based on epidemiology history and seropositivity for paragonimiasis and/or detection of paragonimus eggs. Clinical, laboratory, and imaging findings of patients were examined in order to summarize risk factors, clinical characteristics, and treatment outcomes of these patients.Results:A total of 123 patients were included; of them 112 (91.1%) lived in villages and 72 (58.5%) had a history of consuming freshwater crabs. Patients with paragonimiasis most frequently showed respiratory symptoms, including cough (26.0%, 32/123) and tachypnea (16.3%, 20/123), and gastrointestinal symptoms, including abdominal pain (26.8%, 33/123), abdominal distention (22.8%, 28/123), and vomiting (13.0%, 16/123). Laboratory examination showed elevated white blood cell (WBC) counts in the peripheral blood in 89 (72.4%) patients and eosinophilia in 102 (82.9%) patients. Tuberculosis (TB) coinfection was found in 4 (3.3%) patients. Main imaging findings included: effusions (90.4%), lymphadenopathy (40.4%), pulmonary ground-glass opacities (36.2%), cystic lesions (18.1%), and pleural thickening (17.0%). Twenty-nine patients (23.6%) received more than 1 course of praziquantel (PZQ). Additionally, 4 (19.0%) of 21 patients who were discharged from the hospital without complete treatment required rehospitalization for residual serous effusions. Moreover, patients from pericardial effusion group showed longer hospital stays and less elevated WBC counts than those from nonpericardial effusion group.Conclusion:Paragonimiasis should be considered in patients from endemic areas, especially in those with gastrointestinal and/or respiratory symptoms, elevated WBC count, eosinophilia, and serous effusions. Additionally, longer hospital stay may be necessary in cases of paragonimiasis associated with pericardial effusions.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Paragonimiasis in Children in Southwest China

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“…Huge numbers of people have been screened in this way [ 26 ]. Its use continues to the present day in a number of countries including Colombia [ 40 ], Laos [ 35 ], India [ 133 ], and China [ 129 ].…”

Section: Commonly Used Immunological Methodsmentioning

confidence: 99%

“…The proportion of people infected with members of the P. skrjabini complex who develop cerebral symptoms is likely to be relatively high [ 205 ] and lung lesions are much less common [ 129 , 206 ]. Sixteen percent of 213 cases of paragonimiasis due to P. skrjabini in China had symptoms suggestive of neurological involvement (severe headache and vomiting) [ 129 ]. Reports of cerebral paragonimiasis caused by other species are few [ 18 , 42 ].…”

Section: Ectopic Paragonimiasismentioning

confidence: 99%