Distribution and Elimination of Poly (methyl methacrylate) Nanoparticles After Subcutaneous Administration to Rats

Kreuter, Jörg; Nefzger, M.; Liehl, E.; Czok, R.; Voges, Rolf

doi:10.1002/jps.2600721009

Cited by 34 publications

References 12 publications

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in vivo targeting of colloidal carriers by novel graft copolymers

Arshady

1996

J. Mol. Recognit.

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One of the major obstacles to the targeted delivery of colloidal carriers (nanocapsules) is the body's own defence mechanism in capturing foreign particles by the reticuloendothelial system (RES). This means that following intravenous administration, practically all nanometer size particles are captured by the RES (mainly the liver). This paper draws attention to a recent initiative on the design of 'macromolecular homing devices' which seem to disguise nanoparticles from the RES, and hence are of potential interest for the targeted delivery of nanocapsular carriers. The idea is based on a graft copolymer model embodying a link site for attachment (binding) to the carrier, a floating pad for maintaining the particles afloat in the blood stream, an affinity ligand for site-specific delivery and a structural tune for balancing the overall structure of the homing device. A general synthetic scheme for the preparation of such graft copolymers is given, and preliminary biological evaluations relating to the floating pad concept are discussed.

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in vivo targeting of colloidal carriers by novel graft copolymers

Arshady

1996

J. Mol. Recognit.

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Distribution and Elimination of Polymethyl Methacrylate Nanoparticles After Peroral Administration to Rats

Nefzger

Kreuter

Voges³

et al. 1984

Journal of Pharmaceutical Sciences

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Materials in particulate form for tissue engineering. 1. Basic concepts

Silva

Ducheyne

Reis

2007

J Tissue Eng Regen Med

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For biomedical applications, materials small in size are growing in importance. In an era where 'nano' is the new trend, micro-and nano-materials are in the forefront of developments. Materials in the particulate form aim to designate systems with a reduced size, such as micro-and nanoparticles. These systems can be produced starting from a diversity of materials, of which polymers are the most used. Similarly, a multitude of methods are to produce particulate systems, and both materials and methods are critically reviewed here. Among the varied applications that materials in the particulate form can have, drug delivery systems are probably the most prominent, as these have been in the forefront of interest for biomedical applications. The basic concepts pertaining to drug delivery are summarized, and the role of polymers as drug delivery systems conclude this review. JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE R E V I E W A R T I C L E

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Distribution and Elimination of Poly (methyl methacrylate) Nanoparticles After Subcutaneous Administration to Rats

Cited by 34 publications

References 12 publications

in vivo targeting of colloidal carriers by novel graft copolymers

in vivo targeting of colloidal carriers by novel graft copolymers

Distribution and Elimination of Polymethyl Methacrylate Nanoparticles After Peroral Administration to Rats

Materials in particulate form for tissue engineering. 1. Basic concepts

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