Distribution and Frequency of Salivary Gland Tumours: An International Multicenter Study

Abstract

Background Salivary gland tumours (SGT) are a relatively rare group of neoplasms with a wide range of histopathological appearance and clinical features. To date, most of the epidemiological studies on salivary gland tumours are limited for a variety of reason including being out of date, extrapolated from either a single centre or country studies, or investigating either major or minor glands only. Methods This study aimed to mitigate these shortcomings by analysing epidemiological data including demographic, anatomical location and histological diagnoses of SGT from multiple centres across the world. The analysed data included age, gender, location and histological diagnosis from fifteen centres covering the majority of the world health organisation (WHO) geographical regions between 2006 and 2019. Results A total of 5739 cases were analysed including 65% benign and 35% malignant tumours. A slight female predilection (54%) and peak incidence between the fourth and seventh decade for both benign and malignant tumours was observed. The majority (68%) of the SGT presented in major and 32% in the minor glands. The parotid gland was the most common location (70%) for benign and minor glands (47%) for malignant tumours. Pleomorphic adenoma (70%), and Warthin’s tumour (17%), were the most common benign tumours whereas mucoepidermoid carcinoma (26%) and adenoid cystic carcinoma (17%) were the most frequent malignant tumours. Conclusions This multicentre investigation presents the largest cohort study to date analysing salivary gland tumour data from tertiary centres scattered across the globe. These findings should serve as a baseline for future studies evaluating the epidemiological landscape of these tumours.

An organoid library of salivary gland tumors reveals subtype-specific characteristics and biomarkers

“…SGTs are one of the most challenging areas for diagnostic pathology, with a lower incidence of about 0.5–2 cases per 100.000 yearly [ 1 – 3 ], but a large number of subgroups for pathological classification, including 11 types of benign and 20 types of malignant entities of epithelial origin [ 4 ]. These subtypes often display similar aberrant and pleomorphic structures, such as solid, trabecular, tubular, glandular and ductal patterns, papillary projections, cystic space, and so on.…”

Expression of Syndecan-1 and Cyclin D1 in Salivary Gland Tumors in Relation to Clinicopathological Parameters

“…19 , 20 While Iraqi research and further international multicentre study illustrated high prevalence in old age groups. 21 , 22 …”

Full-Thickness Craniodural Metastasis with Leptomeningeal Infiltration of Salivary Origin: A Radiological Lesson and a Technical Remark

“…Salivary gland tumors are rare and divided into several histopathological groups, generally affecting the parotid gland in near the 70% of the cases [ 8 ], while, consequently, the submandibular glands are involved in fewer cases. Moreover, malignant salivary glands tumors are even less common than the benign ones, accounting for 20% of the cases [ 8 , 9 ].…”

“…Salivary gland tumors are rare and divided into several histopathological groups, generally affecting the parotid gland in near the 70% of the cases [ 8 ], while, consequently, the submandibular glands are involved in fewer cases. Moreover, malignant salivary glands tumors are even less common than the benign ones, accounting for 20% of the cases [ 8 , 9 ]. Seldom, papers in the whole of the English literature reported rare cases of intracranial metastasis deriving from salivary gland tumors [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ].…”