Distribution of cannabinoid receptor 1 in the CNS of zebrafish

Lam, Chen Sok; Rastegar, Sepand; Strähle, Uwe

doi:10.1016/j.neuroscience.2005.10.069

Cited by 90 publications

(99 citation statements)

References 60 publications

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“…Overall, the early expression and functionality of the CB 1 receptor during nervous system development and its transient and atypical localization in prenatal stages suggest a specific role of the ECB system in human brain development, with potential implications in neuropsychiatric disorders [6,26]. [31,32], its expression pattern in the nervous system of the zebrafish is suggestive of its involvement in neurogenesis [33]. Neurospheres (non-adherent in vitro culture of NP cells) from embryonic and postnatal development stages express CB 1 receptors and the anandamide (AEA)-degrading enzyme fatty acid amide hydrolase (FAAH), and elevations in their intracellular Ca 2þ concentration increase ECB production [29].…”

Section: The Endocannabinoid System In the Developing Brainmentioning

confidence: 95%

Endocannabinoids via CB₁receptors act as neurogenic niche cues during cortical development

Díaz-Alonso

Guzmán

Galve‐Roperh

2012

Phil. Trans. R. Soc. B

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During brain development, neurogenesis is precisely regulated by the concerted action of intrinsic factors and extracellular signalling systems that provide the necessary niche information to proliferating and differentiating cells. A number of recent studies have revealed a previously unknown role for the endocannabinoid (ECB) system in the control of embryonic neuronal development and maturation. Thus, the CB 1 cannabinoid receptor in concert with locally produced ECBs regulates neural progenitor (NP) proliferation, pyramidal specification and axonal navigation. In addition, subcellularly restricted ECB production acts as an axonal growth cone signal to regulate interneuron morphogenesis. These findings provide the rationale for understanding better the consequences of prenatal cannabinoid exposure, and emphasize a novel role of ECBs as neurogenic instructive cues involved in cortical development. In this review the implications of altered CB 1 -receptor-mediated signalling in developmental disorders and particularly in epileptogenesis are briefly discussed.

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Section: The Endocannabinoid System In the Developing Brainmentioning

confidence: 95%

Endocannabinoids via CB₁receptors act as neurogenic niche cues during cortical development

Díaz-Alonso

Guzmán

Galve‐Roperh

2012

Phil. Trans. R. Soc. B

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“…Expression is also evident in the hypothalamus and posterior tuberculum (diencephalon) and in the torus longitudinalis (mesencephalon) [90]. [86,91].…”

Section: Comparative Neurobiology Of Endocannabinoid Signallingmentioning

confidence: 99%

The evolution and comparative neurobiology of endocannabinoid signalling

Elphick

2012

Phil. Trans. R. Soc. B

153

137

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CB 1 -and CB 2 -type cannabinoid receptors mediate effects of the endocannabinoids 2-arachidonoylglycerol (2-AG) and anandamide in mammals. In canonical endocannabinoid-mediated synaptic plasticity, 2-AG is generated postsynaptically by diacylglycerol lipase alpha and acts via presynaptic CB 1 -type cannabinoid receptors to inhibit neurotransmitter release. Electrophysiological studies on lampreys indicate that this retrograde signalling mechanism occurs throughout the vertebrates, whereas system-level studies point to conserved roles for endocannabinoid signalling in neural mechanisms of learning and control of locomotor activity and feeding. CB 1 /CB 2 -type receptors originated in a common ancestor of extant chordates, and in the sea squirt Ciona intestinalis a CB 1 / CB 2 -type receptor is targeted to axons, indicative of an ancient role for cannabinoid receptors as axonal regulators of neuronal signalling. Although CB 1 /CB 2 -type receptors are unique to chordates, enzymes involved in biosynthesis/inactivation of endocannabinoids occur throughout the animal kingdom. Accordingly, non-CB 1 /CB 2 -mediated mechanisms of endocannabinoid signalling have been postulated. For example, there is evidence that 2-AG mediates retrograde signalling at synapses in the nervous system of the leech Hirudo medicinalis by activating presynaptic transient receptor potential vanilloid-type ion channels. Thus, postsynaptic synthesis of 2-AG or anandamide may be a phylogenetically widespread phenomenon, and a variety of proteins may have evolved as presynaptic (or postsynaptic) receptors for endocannabinoids.

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“…Nevertheless, although bony fish have multiple gene copies in some way related to their evolutionary radiation and phenotypic diversification, at the moment, Fugu and Solea solea (Palermo et al, submitted) are the only teleosts, among those investigated, with two CB1 receptor subtypes. Pelvicachromis pulcher (Cottone et al, 2005a), Carassius auratus (Valenti et al, 2005), Danio rerio (Lam et al, 2006) and Sparus aurata (Ruggeri et al, 2007) are in fact all provided with only one CB1 receptor subtype showing a highest sequence homology with Fugu CB1A.…”

Section: Functional Relevance Of Cannabinoid Cb1 Receptors In Teleostmentioning

confidence: 99%

“…The distribution of CB1 receptors has been investigated, by using specific primary antibodies against the rat CB1 (Tsou et al, 1998), in adult brains of both Pelvicachromis pulcher (Cottone et al, 2005a) and goldfish (Valenti et al, 2005), while the CB1 ontogeny was analysed in zebrafish larvae and adults by means of in situ hybridization (Lam et al, 2006). In the adult brains the CB1-likeimmunoreactivity (CB1-LI-IR) was extended through all the telencephalon and a number of CB1 immunostained cell bodies were located immediately below the ventricular ependyma, which is considered a proliferation zone in the adult fish brain (Kirsche, 1967;Ekstrőm et al, 2001;Zupanc and Zupanc, 2006).…”

Section: Functional Relevance Of Cannabinoid Cb1 Receptors In Teleostmentioning

confidence: 99%

“…The in situ hybridization for CB1 mRNA on zebrafish larvae brain (Lam et al, 2006) has shown an early CB1 expression in the preoptic area and, later, within the dorsal telencephalon and mesodiencephalon, brain areas rich in CB1 in the adult teleosts (Cottone et al, 2005a;Valenti et al, 2005;Lam et al, 2006). In postembryonic larvae CB1 distribution is closely resembling the adult one and the prosencephalic cannabinergic innervation is topographically related to areas interested by the concomitant differentiation of classic neurotransmitter systems (GABA, Dopamine), accordingly to what reported in the fetal brains of human and rat (Fernandez-Ruiz et al, 2004).…”

Section: Functional Relevance Of Cannabinoid Cb1 Receptors In Teleostmentioning

confidence: 99%

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Endocannabinoids affect the reproductive functions in teleosts and amphibians

Cottone

Guastalla

Franzoni

2008

Molecular and Cellular Endocrinology

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Following the discovery in the brain of the bonyfish Fugu rubripes of two genes encoding for type 1 cannabinoid receptors (CB1A and CB1B), investigations on the phylogeny of these receptors have indicated that the cannabinergic system is highly conserved. Among the multiple functions modulated by cannabinoids/endocannabinoids through the CB1 receptors one of the more investigated is the mammalian reproduction. Therefore, since studies performed in animal models other than mammals might provide further insight into the biology of these signalling molecules, the major aim of the present paper was to review the comparative data pointing toward the endocannabinoid involvement in the reproductive control of non mammalian vertebrates, namely bonyfish and amphibians.The expression and distribution of CB1 receptors were investigated in the CNS and gonads of two teleosts, Pelvicachromis pulcher and Carassius auratus as well as in the anuran amphibians Xenopus laevis and Rana esculenta. In general the large diffusion of neurons targeted by cannabinoids in both fish and amphibian forebrain indicate endocannabinoids as pivotal local messengers in several neural circuits involved in either sensory integrative activities, like the olfactory processes (in amphibians) and food response (in bonyfish), or neuroendocrine machinery (in both). By using immunohistochemistry for CB1 and GnRH, the codistribution of the two signalling molecules was found in the fish basal telencephalon and preoptic area, which are key centers for gonadotropic regulation in all vertebrates. A similar topographical codistribution was observed also in the septum of the telencephalon in Rana esculenta and Xenopus laevis.Interestingly, the double standard immunofluorescence on the same brain section, aided with a laser confocal microscope, showed that in anurans a subset of GnRH neurons exhibited also the CB1 immunostaining. The fact that CB1-LI-IR was found indeed in the FSH gonadotrophs of the Xenopus pituitary gland and CB1 receptors together with the fatty acid amide hydrolase, the degradative enzyme of the endocannabinoid anandamide, were demonstrated in both bonyfish and frog gonads, strongly suggests that endocannabinoids are involved in central and peripheral gonadotropic functions of teleosts and amphibians.

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Distribution of cannabinoid receptor 1 in the CNS of zebrafish

Cited by 90 publications

References 60 publications

Endocannabinoids via CB₁receptors act as neurogenic niche cues during cortical development

Endocannabinoids via CB₁receptors act as neurogenic niche cues during cortical development

The evolution and comparative neurobiology of endocannabinoid signalling

Endocannabinoids affect the reproductive functions in teleosts and amphibians

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Distribution of cannabinoid receptor 1 in the CNS of zebrafish

Cited by 90 publications

References 60 publications

Endocannabinoids via CB1receptors act as neurogenic niche cues during cortical development

Endocannabinoids via CB1receptors act as neurogenic niche cues during cortical development

The evolution and comparative neurobiology of endocannabinoid signalling

Endocannabinoids affect the reproductive functions in teleosts and amphibians

Contact Info

Product

Resources

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Endocannabinoids via CB₁receptors act as neurogenic niche cues during cortical development

Endocannabinoids via CB₁receptors act as neurogenic niche cues during cortical development