Distribution of Hepatitis C virus genotypes in city of Mashhad, North-east of Iran

Rastin, Maryam; Mahmoudi, Mahmoud; Rezaee, Seyed Abdolrahim; Assarehzadegan, Mohammad-Ali; Tabasi, Nafiseh; Zamani, Saman; Nosratabadi, Reza; Haghmorad, Dariush; Sheikh, Aisha; Khazaee, Mahdieh; Panah, HR

doi:10.4103/0255-0857.124306

Cited by 7 publications

(5 citation statements)

References 14 publications

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“…There was only one report from Afghanistan, which showed predominance of subtype 3a, followed by subtype 1a ( 13 ). Due to war and political instability in Afghanistan, a tremendous number of Afghan immigrants usually make many trips between Iran, Afghanistan, and Pakistan ( 14 ), which may explain the HCV genotypes in Afghanistan. In the Middle East Arab countries genotypes 4 and 1 were predominant with two different distribution patterns; genotype 4 was the most common genotype in Saudi Arabia, Kuwait, Qatar, Syria, and Palestinian, while genotype 1 was found with higher frequency in Jordan, Lebanon, Iraq, Bahrain, and the United Arab Emirates.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Hepatitis C Virus Genotypes Among Patients in Countries of the Eastern Mediterranean Regional Office of WHO (EMRO): A Systematic Review and Meta-Analysis

et al. 2016

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ContextHepatitis C virus (HCV) infection is a major global public health issue. The Eastern Mediterranean regional office (EMRO) of the world health organization (WHO) seems to have one of the highest prevalence rates worldwide, with at least 21.3 million HCV-infected patients.ObjectivesThe aim of the present study was to review systematically all epidemiological data related to the prevalence of HCV genotypes in infected patients in EMRO countries.Data SourcesA systematic search was conducted of peer-reviewed journals indexed in electronic databases (PubMed, Scopus, ISI, PakMediNet, and IMEMR, and Persian-specific databases including SID, Iran Medex, and MagIran).Study SelectionA systematic search was performed with temporal limits (papers published between January 2000 up to June 2015), regarding the prevalence and distribution of HCV genotypes in EMRO countries.Data ExtractionThe prevalence rates of HCV genotypes were pooled by metan command in Stata 14. Statistical heterogeneity was explored using the I-square at the 5% significance level. Publication bias was assessed, graphically and statistically, by funnel plot and Begg and Egger tests.ResultsA total of 563 records were identified through the electronic search. Of these records, 134 studies comprising 67681 HCV-infected individuals were included in the meta-analysis. In Iran, subtype 1a was the predominant subtype with a rate of 42% (95% CI, 39 - 46), followed by subtype 3a, 35% (95% CI, 31 - 38). In Pakistan, Subtype 3a was the most common subtype with a rate of 56% (95% CI, 49 - 62), followed by subtype 3b, 10% (95% CI, 7 - 12). In Saudi Arabia and Egypt, genotype 4 was the most prevalent genotype with a rate of 65% (95% CI, 59 - 72) and 69% (95% CI, 36 - 100) respectively. In Tunisia and Morocco, subtype 1b was the most common subtype with a rate of 69% (95% CI, 50 - 88) and 32% (95% CI, 7 - 56) respectively.ConclusionsThe genotype distribution of HCV takes diverse patterns in EMRO countries. Genotypes 1 and 3 were predominant in Iran and Pakistan, while genotype 4 and 1 were the most common genotypes in the Middle East Arab countries and North African Arab countries. Understanding the genotypes of HCV can help policy makers in designing good strategies for treatment.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Hepatitis C Virus Genotypes Among Patients in Countries of the Eastern Mediterranean Regional Office of WHO (EMRO): A Systematic Review and Meta-Analysis

et al. 2016

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“…The frequency of HCV genotypes in different geographic regions is variable and changes over time, depending on the study population, the route of infection and virus mutation ( 3 , 11 ). Considering countries around Iran, the predominant HCV subtype is 1b in Turkey, Russia, Moldova and Uzbekistan ( 10 ), 4 in Saudi Arabia, Iraq, Qatar, Bahrain, Kuwait and Yemen ( 12 ), and 6a in China ( 3 ).…”

Section: Discussionmentioning

confidence: 99%

“…During the past few years, due to the political situation of Afghanistan, a considerable number of immigrants came to Iran. These immigrants usually do many trips between Iran, Afghanistan and Pakistan ( 11 ).…”

Section: Discussionmentioning

confidence: 99%

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Prevalence of Hepatitis C Virus Genotypes in Iranian Patients: a Systematic Review and Meta-Analysis

Khodabandehloo¹,

Roshani²

2014

Hepat Mon

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Context:Hepatitis C virus (HCV) is a global public health problem and a major etiology of chronic liver disease, which may develop into cirrhosis and hepatocellular carcinoma. Genotypes of HCV indicate the route of acquisition, the clinical outcome, response to treatment, prognosis and control strategies.Objectives:The aim of this study was to estimate the overall prevalence and trend of HCV genotypes or subtypes in IranData Sources:A literature review was done for papers reporting HCV genotypes in Iranian patients in PubMed, Magiran, IranMedex, Scientific Information Databank, and Google scholar databases.Study Selection:Data were selected according to inclusion and exclusion criteria.Data Extraction:Data were abstracted by two independent authors. Data were analyzed based on random-effects model using the Meta R. Pooled statistical software. Prevalence of HCV genotypes in cities and provinces of Iran with 95% confidence interval (CI) were calculated.Results:Fifty-three articles published between 1999 and 31 June 2014 including 22952 HCV infected individuals were included in the meta-analysis. Subtype 1a was predominant with a rate of 39% (95% CI: 34-44%); followed by subtype 3a, 32% (95% CI: 26-39%); subtype 1b, 13% (95% CI: 10-15%); genotype 4, 5.18% (95% CI: 3.27-7.5%); and genotype 2, 3.6% (95% CI: 1.6-8.3%). Untypeable HCV had a rate of 0.11% (95% CI: 0.07-0.16%).Conclusions:The most frequent subtypes of HCV in Iran were 1a, 3a and 1b, respectively. This frequency differed in various provinces of Iran and fluctuated with time. It is important to determine the distribution of HCV genotypes in different geographical areas and its trend with time for epidemiological and patients’ management purposes.

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“…In Isfahan, Shanehsazzadeh et al identified most samples with genotype 3a followed by 1a and 1b in this population (19). In Mashhad, the prevalence of 3a, 1a, 1b, 2a and mixed genotypes in 278 samples was reported as 49.6%, 36.3%, 12.6%, 0.4% and 1.4% respectively (20). Genotypes 1a was previously predominant in Tehran followed by 3a and 1b, but an increase in genotype 3a took place from 2003 to 2011 (11).…”

Section: Discussionmentioning

confidence: 99%

Distribution of Hepatitis C virus genotypes in Yazd, Central Province of Iran: increasing the mixed genotypes

et al. 2016

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Background and Aims: Different hepatitis C virus (HCV) genotypes have characteristic geographical distribution. Identification of HCV genotype is an important factor in the progression, clinical outcome and therapy of HCV infection. The aim of this study was to determine the prevalence of HCV genotypes among HCV-RNA positive patients in Yazd, Iran. Materials and Methods: In this cross-sectional study, 150 HCV-infected individuals with detectable plasma HCV RNA levels were enrolled from January to August 2015. HCV-RNA was extracted from plasma samples and retro-transcribed to c-DNA. Then HCV genotypes 1, 2, 3a, 4 were determined using a PCR based genotyping kit. Results: A total of 150 HCV-positive patients with mean age 40.45±11.83 were enrolled in the study. 89.3% of participant were males and 10.7% were females. The most common genotype was 3a (52%), followed by 1a (28%). Mixed-genotype infection was 20% and the most prevalent mixed genotype was 3a/1a (83% of mixed genotypes). The other genotypes were 1a/1b/3a in 10%, 3a/2 and 1a/2/3a both in 3% of patients with mixed HCV genotypes. Conclusions: Unlike other regions of Iran, Genotypes 3a was predominant in HCV-RNA positive patients in Yazd province. Also, HCV mixed-genotype infections were more common than previously estimated in other studies from different parts of the country.

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Distribution of Hepatitis C virus genotypes in city of Mashhad, North-east of Iran

Abstract: We demonstrated that despite the previous reports on the frequency of HCV genotypes in Iran, 3a is the predominant genotype in Mashhad.

Cited by 7 publications

References 14 publications

Prevalence of Hepatitis C Virus Genotypes Among Patients in Countries of the Eastern Mediterranean Regional Office of WHO (EMRO): A Systematic Review and Meta-Analysis

Prevalence of Hepatitis C Virus Genotypes Among Patients in Countries of the Eastern Mediterranean Regional Office of WHO (EMRO): A Systematic Review and Meta-Analysis

Prevalence of Hepatitis C Virus Genotypes in Iranian Patients: a Systematic Review and Meta-Analysis

Distribution of Hepatitis C virus genotypes in Yazd, Central Province of Iran: increasing the mixed genotypes

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