Distribution of HLA‐DQA1 and ‐DQB1 alleles and DQA1‐DQB1 genotypes among Senegalese patients with insulin‐dependent diabetes mellitus

Cissé, A; Chauffert, M; Chevenne, Didier; Parfait, Béatrice; Julier, Cécile; Assouline, Z.; Michel, Simone; Trivin, F

doi:10.1111/j.1399-0039.1996.tb02562.x

Cited by 10 publications

(5 citation statements)

References 20 publications

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“…Also results in the current study agreed with Sabbah E. et al [26] , whom published that presently it is accepted that type 1 DM in children is associated with HLA DR3, DQB1 0201 and DR4, DQB1 0302. Whereas results in the current study are disagree with Ciss et al [27] , whom stated that there were no significant association between IDDM and any alleles of HLA-DRB1 locus. The disagreement is continuous with Vehik K. and Fourlanos S. [28,29] , they stated that interestingly, however, as T1D incidence increases, the percentage of those cases with the high-risk HLADR3/4 genotype seems to be decreasing.…”

Section: Table (1): Frequencies Of Hla-drb1 Typing Among the Study Gr...contrasting

confidence: 99%

HLA-DRB1typing among Type I Diabetic Patients and their First Degree relatives in a Comparative Study

Aleqabi

Al-Kaabi

Al-Mousawi

et al. 2015

Kufa Jour. Nurs. Sci.

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Background: The genetic susceptibility to IDDM maps to the MHC class II region, thus one approach to investigating the immunopathogenesis of diabetes is to study first degree relatives of affected individuals. Objectives: To detect the inherited relationship between (HLA-DRB1) allels and type one Diabetic mellitus. Methodology: A case-control study was performed on 90 persons, they divided into three group which are diabetic, siblings and control (30 persons in each group), who attended to Al Zahraa Teaching Hospital /Diabetic Center in Al Kut/Iraq between the period of April; 2012 till April; 2013.data was analyzed by using SPSS 16th version. Distribution of HLA-DRB1 loci among the study groups (type 1 Diabetic patients, Siblings and Control group) were performed using MR.SPOT ROBOTING system. Results: results showed that the frequencies of HLA-DRB1*3,*4 {25 (69.4%)} among Diabetic group were Significant (P value = 0.002), in compare to the corresponding frequencies among control group {11 (30.6%)}, in compare to the frequencies of other HLA-DRB1 loci in both Diabetic group and Control group { 15 (34.1%), 29 (65.9%)} respectively. Meanwhile results have showed that there were no Significant (P value = 0.116), in the frequencies of HLA-DRB1*3,*4 {25 (58.1%)} among Diabetic group in compare to the frequencies of HLA-DRB1*3,*4 {18 (41.9%)} among Siblings group, in compare to the frequencies of other HLA-DRB1 loci among Diabetic group and Sibling group {15 (40.5%), 22 (59.5%)} respectively, also results have showed that there were no Significant (P value = 0.104), in the frequencies of HLA-DRB1*3,*4 {18 (62.1%)} among Sibling group in compare to the frequencies of HLA-DRB1*3,*4 {11 (37.9%)} among Control group, in compare to the frequencies of other HLA-DRB1 loci among Sibling group and Control group {22 (43.1%), 29 (56.9%)} respectively. conclusion: In conclusion there were a genetic predisposition of diabetic Siblings for development of Diabetes since, both Diabetic group and Sibling group showing the highest frequencies of HLA-DRB1 *3,*4, in compare to Control group. Recommendation: larger sample group are required to include other allels

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Section: Table (1): Frequencies Of Hla-drb1 Typing Among the Study Gr...contrasting

confidence: 99%

HLA-DRB1typing among Type I Diabetic Patients and their First Degree relatives in a Comparative Study

Aleqabi

Al-Kaabi

Al-Mousawi

et al. 2015

Kufa Jour. Nurs. Sci.

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“…The strongest markers of susceptibility to type 1 diabetes found in this study were the DQA1*0301 and DQB1*0201 phenotypes. These findings are consistent with data from international studies, supporting the hypothesis that these could be good markers in areas where the disease is relatively rare (Cisse et al. , 1996; Dorman et al.…”

Section: Discussionsupporting

confidence: 90%

“…This study confirms the geographical and ethnic variation in the predisposition to type 1 diabetes and the protective effect of the DRB1*13 phenotype (Cisse et al. , 1996).…”

Section: Discussionsupporting

confidence: 85%

“…The results obtained in the present study do not support an association of DR4 with type 1 diabetes in African populations. Although in Zimbabwe an independent predisposition related to this phenotype has been shown, DR4 in several other groups has been found not to predispose to type 1 diabetes unless it is expressed together with some specific DQB1 alleles (Cisse et al. , 1996).…”

Section: Discussionmentioning

confidence: 99%

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HLA‐DRB1, ‐DQA1, ‐DQB1 and DPB1 susceptibility alleles in Cameroonian type 1 diabetes patients and controls

Mbanya

Sobngwi²,

Mbanya³

2001

European Journal of Immunogenetics

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It is known that certain combinations of alleles within the human leucocyte antigen (HLA) complex are associated with susceptibility or resistance to type 1 diabetes. Variable associations of DR and DQ with type 1 diabetes are documented in Caucasians but rarely in African populations; however, the role of HLA-DP genes in type 1 diabetes remains uncertain. In order to investigate the HLA class II associations with type 1 diabetes in Cameroonians, we used sequence-specific oligonucleotide probing (SSOP) to identify DRB1, DQA1, DQB1 and DPB1 alleles in 10 unrelated C-peptide negative patients with type 1 diabetes and 90 controls from a homogeneous population of rural Cameroon. We found a significantly higher frequency of the alleles DRB1*03 (chi2 = 17.9; P = 0.001), DRB1*1301 (chi2 = 37.4; P < 0.0001), DQA1*0301 (chi2 = 18.5; P = 0.001) and DQB1*0201 (chi2 = 37.4; P < 0.001) in diabetes patients compared to the control group. The most frequent alleles in the control population were DQA1*01, DQB1*0602 and DRB1*15. The DRB1*04 allele was not significantly associated with type I diabetes in our study population. We observed no significant difference between patients and controls in DPB1 allele frequency. In conclusion, the data in Cameroonian diabetes patients suggest the existence of HLA class II predisposing and specific protective markers, but do not support previous reports of a primary association between HLA-DP polymorphism and development of type I diabetes.

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“…Differences in disease associations between the Jamaican and white Caucasian populations were observed, however, resulting from differences in frequency of diseaseassociated DRB1 and DQ alleles and diversity of DRB1-DQ haplotypes between the populations. The results of the current study, together with those from our previous study of UK-resident Jamaicans, were compared with those from studies of African heritage populations from Senegal (West Africa) (Cisse et al , 1996), Zimbabwe (East Africa) (Garcia-Pacheco et al , 1992) and America (African-Americans) (Fernandez-Vina et al , 1993) and of British white Caucasians (Cavan et al , 1993) (Table 6).…”

Section: Discussionmentioning

confidence: 99%

HLA‐DQ and DRB1 polymorphism and susceptibility to type 1 diabetes in Jamaica

Heward

Mijovic²,

Kelly³

et al. 2002

European Journal of Immunogenetics

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Genetic susceptibility to type 1 diabetes is determined by a combination of HLA-DQ and DRB1 alleles. In the present study, HLA associations with type 1 diabetes were investigated in the Jamaican population. DRB1 and DQ genotyping was performed on 45 type 1 diabetic patients and 132 control subjects born and resident in Jamaica. The small number of patients available for study reflected the low prevalence of type 1 diabetes in Jamaica. The results were compared with those from other African heritage populations and white Caucasians. The highest relative risk was associated with the DRB1*03-DQ2/DRB1*04-DQ8 genotype. Both DRB1*0401-DQ8 and DRB1*0408-DQ8 were positively associated with disease. DRB1*0408-DQ8 is uncommon amongst white Caucasians, where DRB1*0401-DQ8 is the major predisposing haplotype. The DRB1*1503-DQ6 haplotype was associated with protection from diabetes in the Jamaican population. This haplotype is rare amongst white Caucasians, where DRB1*1501-DQ6 is the protective haplotype. Data from African heritage populations suggest that DRB1*1503-DQ6 might be less protective than DRB1*1501-DQ6. DRB1*03-DQA1*0401-DQB1*0402 was associated with protection from diabetes in the Jamaican population, whereas in white Caucasians DRB1*08-DQA1*0401-DQB1*0402 is predisposing. These data demonstrate that comparison of genetic associations with type 1 diabetes in races with population-specific DRB1-DQ haplotypes provides new information as to the exact determinants of disease susceptibility. Further support is provided for roles of the DQ genes and the DRB1 gene (or a gene in linkage disequilibrium with it) in determining susceptibility to type 1 diabetes.

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Distribution of HLA‐DQA1 and ‐DQB1 alleles and DQA1‐DQB1 genotypes among Senegalese patients with insulin‐dependent diabetes mellitus

Cited by 10 publications

References 20 publications

HLA-DRB1typing among Type I Diabetic Patients and their First Degree relatives in a Comparative Study

HLA-DRB1typing among Type I Diabetic Patients and their First Degree relatives in a Comparative Study

HLA‐DRB1, ‐DQA1, ‐DQB1 and DPB1 susceptibility alleles in Cameroonian type 1 diabetes patients and controls

HLA‐DQ and DRB1 polymorphism and susceptibility to type 1 diabetes in Jamaica

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