Distribution of protein-bound zinc in normal and cirrhotic serum

Boyett, John D.

doi:10.1016/0026-0495(70)90106-x

Cited by 13 publications

(15 citation statements)

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“…The serum zinc concentrations increased or remained unchanged in 84.3% of patients with C-viral chronic liver disease when zinc was administered, but 15.6% of patients showed a reduction in their zinc concentrations. It is known that serum zinc concentrations decreased in patients with liver disease in parallel with the development of disease stage because zinc absorption from the intestine decreases and the zinc content of the liver reduces due to the decrease in the number of functional hepatocytes [18–22]. However, our study suggests that the serum zinc concentrations can increase in the majority of patients if a sufficient quantity of zinc is administered.…”

Section: Discussionmentioning

confidence: 58%

Zinc Supplementation Improves the Outcome of Chronic Hepatitis C and Liver Cirrhosis

Matsuoka

Matsumura

Nakamura

et al. 2009

J. Clin. Biochem. Nutr.

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Summary We treated patients with C-viral chronic hepatitis (CH) and liver cirrhosis (LC) with polaprezinc and determined prospectively the effect on long-term outcome. 62 patients were enrolled. Of these, 32 were administered 1.0 g polaprezinc and the remainder were not administered polaprezinc. We measured the serum zinc concentrations using conventional atomic absorption spectrometry and conducted a prospective study to determine the long-term outcome of the polaprezinc therapy. Changes of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in the polaprezinc administration group were significantly lower than those of the untreated group. The decrease in platelet count was clearly less than that of the untreated group. The factors that inhibited increases in serum zinc concentrations following administration of polaprezinc included low serum zinc concentration states. Furthermore, the reductions of AST and ALT levels in the low zinc group were significantly greater than those of the high zinc group. When the patients who were administered polaprezinc were divided into two groups whose zinc concentrations increased (zinc responders) or remained stable or decreased (zinc non-responders), the zinc responders had a clearly lower cumulative incidence of HCC than the zinc non-responders. We conclude zinc supplementation improved the long-term outcome in C-viral CH and LC patients.

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Section: Discussionmentioning

confidence: 58%

Zinc Supplementation Improves the Outcome of Chronic Hepatitis C and Liver Cirrhosis

Matsuoka

Matsumura

Nakamura

et al. 2009

J. Clin. Biochem. Nutr.

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“…Zinc is normally transported bound to albumin (Boyett & Sullivan, 1970), aj-macroglobulin (Parisi & Vallee, 1970;Giroux, 1975;Burns & Fell, 1976) and amino acids, especially histidine and cysteine (Giroux & Henkin, 1972). The majority of zinc (approximately 60%) is probably bound to sertom albumin, although opinions on this point vary in the literature (Prasad & Oberleas, 1970;Henkin, 1973;Burch, Hahn & Sullivan, 1975).…”

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confidence: 99%

Plasma zinc-serum albumin correlation: relevance to assessment of zinc status in humans

McMillan¹,

Rowe²

1982

Clin Exp Dermatol

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Summary Plasma zinc and serum albumin were measured in an ostensibly healthy group of volunteers. Calculation of the correlation coefficient showed a small but significant correlation between plasma zinc and serum albumin in the total group studied (r= 0·35, P<0·05), The results indicate that in healthy individuals there is a small but significant correlation between serum filbumin and plasma zinc, but the low degree of correlation would suggest that there are other variables affecting plasma zinc in health. However, the demonstration of this correlation suggests that additional information may be obtained in studies of zinc status by concomitant serum albumin measurement.

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“…35], hormones [8,10,19], pregnancy [14,16,40], ovulatory cycle [14,15], diurnal and circadian rhythms [9, 18. 21,28, 30, 46, 47], fasting [13,23,47], starvation [20,36], alterations in plasma al bumin and total protein [5,12,22,46] and venous occlusion prior to venepuncture [48], In the present study the influence of feed and zinc intake on postprandial plasma zinc concentrations were examined.…”

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confidence: 99%

Postprandial Plasma Zinc Changes in Pigs

Lantzsch

Berschauer²

1982

Ann Nutr Metab

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In growing male pigs fitted with jugular catheters, changes in plasma zinc concentrations were followed up to 330 min postprandially. In pigs with normal fasting zinc values ( > 70 µg/100 ml) plasma levels decreased significantly (p < 0.05) up to 35% below, whereas in pigs with lowered fasting values plasma level increased up to 36% above the respective fasting values within 120 and 180 min after feed intake. The amount of feed administered was without effect on the postprandial decline. No dose-response relationship between the intake of graded amounts of zinc in the inorganic (ZnSO₄) or naturally bound form (barley) and changes in plasma zinc level was found.

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Distribution of protein-bound zinc in normal and cirrhotic serum

Cited by 13 publications

References 0 publications

Zinc Supplementation Improves the Outcome of Chronic Hepatitis C and Liver Cirrhosis

Zinc Supplementation Improves the Outcome of Chronic Hepatitis C and Liver Cirrhosis

Plasma zinc-serum albumin correlation: relevance to assessment of zinc status in humans

Postprandial Plasma Zinc Changes in Pigs

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