Distribution of Α‐ and Β‐adrenoceptors in Human Urinary Bladder

Awad, Said A.; Bruce, Andrew W.; Carro-Ciampi, Giovanna; Downie, John W.; Lin, Mengjuan; Marks, Gerald S.

doi:10.1111/j.1476-5381.1974.tb08585.x

Cited by 131 publications

(40 citation statements)

References 19 publications

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“…The function of sympathetic innervation is opposite to that of parasympathetic innervation. The release of sympathetic neurotransmitter noradrenalin causes that the detrusor is blocked by inhibitory β-adrenergic receptors and both the bladder neck and the smooth-muscular urethra are tonicized by excitatory detrusor α-adrenergic receptors, thus achieving continence (Nergardh and Boreus 1972, Edvardsen and Setekleiv 1968, Salimi et al 1969, Raezer et al 1973, Awad et al 1974, Levin and Wein 1979. Therefore, the observed increase in the number of adrenergic nerve fibers could be a factor which additionally decreases the spasticity of the overreactive bladder and for that reason improves the treatment.…”

Section: H/npymentioning

confidence: 99%

The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibers supplying the porcine urinary bladder wall

Lepiarczyk¹,

Bossowska²,

Kaleczyc³

et al. 2011

Polish Journal of Veterinary Sciences

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Botulinum toxin (BTX) belongs to a family of neurotoxins which strongly influence the function of autonomic neurons supplying the urinary bladder. Accordingly, BTX has been used as an effective drug in experimental therapies of a range of neurogenic bladder disorders. However, there is no detailed information dealing with the influence of BTX on the morphological and chemical properties of nerve fibres supplying the urinary bladder wall. Therefore, the present study investigated, using double-labeling immunohistochemistry, the distribution, relative frequency and chemical coding of cholinergic and noradrenergic nerve fibers supplying the wall of the urinary bladder in normal female pigs (n=6) and in the pigs (n=6) after intravesical BTX injections. In the pigs injected with BTX, the number of adrenergic (DβH-positive) nerve fibers distributed in the bladder wall (urothelium, submucosa and muscle coat) was distinctly higher while the number of cholinergic (VAChT-positive) nerve terminals was lower than that found in the control animals. Moreover, the injections of BTX resulted in some changes dealing with the chemical coding of the adrenergic nerve fibers. In contrast to the normal pigs, in BTX injected animals the number of DβH/NPY-or DβH/CGRP-positive axons was higher in the muscle coat, and some fibres distributed in the urothelium and submucosa expressed immunoreactivity to CGRP. The results obtained suggest that the therapeutic effects of BTX on the urinary bladder might be dependent on changes in the distribution and chemical coding of nerve fibers supplying this organ.

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Section: H/npymentioning

confidence: 99%

The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibers supplying the porcine urinary bladder wall

Lepiarczyk¹,

Bossowska²,

Kaleczyc³

et al. 2011

Polish Journal of Veterinary Sciences

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“…The presence of adrenergic receptors in the human lower urinary tract has been demonstrated both in the outflow region (Awad et al, 1974) and in the prostate (Caine et al, 1975). The pharmacological blockade with phentolamine of the alpha receptors causes a relaxation of the urethral smooth muscle fibres, with decrease in urethral pressure and urethral profile length (Donker et al, 1972;Whitfield et al, 1976).…”

Section: Discussionmentioning

confidence: 99%

Nicergoline in the treatment of neuropathic bladder dysfunction: a preliminary report

Gállego¹,

Forner²,

Jiménez³

et al. 1984

Spinal Cord

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Summary. We have employed the alpha blocking drug Nicergoline in 14 patients with neuropathic bladder dysfunction of the upper motor neurone type.The oral administration of 15-30 mgrs/ day of this drug over a period of 9·5 months significantly improved the urodynamic parameters, with an increase of bladder capacity, a disappearance or amelioration of uninhibited bladder contrac tions and a decrease in urethral pressure, profile urethral length and residual urine.Two patients with vesico-ureteral reflux present before treatment showed radiological improvement after Nicergoline administration.Tolerance of Nicergoline had been excellent without appreciable side effects. In conclusion, Nicergoline seems to be active and well tolerated in the pharmaco logical treatment of neuropathic bladder dysfunction.

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“…Other studies are restricted to a specific connection or function of the neuronal circuitry (e.g. Andersson 1986;Awad et al 1974;Baljet and Drukker 1979;Bradley 1969a, b;Bradley and Conway 1966;Teague 1968a, b, 1969a~1;Coote et al 1982;De Groat and Saum 1971;Donker 1986;DroEs 1972;Elbadawi 1984;Gosling et al 1983;Griffiths et al 1990;Hickey et al 1982;Marani et al 1993;Raz 1978;Tanagho et al 1982;Van Ulden 1975;Venema 1988).…”

Section: Introductionmentioning

confidence: 99%

Neuronal circuitry of the lower urinary tract; central and peripheral neuronal control of the micturition cycle

et al. 1995

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(1995). Neuronal circuitry of the lower urinary tract : central and peripheral neuronal control of the micturition cycle. Anatomy and Embryology, 192(3), 195-209. DOI: 10.1007 /BF00184744General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Anat Embryol (1995) 192:195-209 9 Springer-Verlag 1995 Abstract A new presentation technique is introduced to describe the neuronal circuitry involved in the control of the uropoEtic system and its control mechanisms during the micturition cycle. This method is based on the preparation of flow charts and is applied to the discussion of four qualitative models which are derived from the literature. Opinions concerning the reflex arcs and supraspinal connections said to be involved in micturition and continence are different and sometimes contradictory. Little is known about how autonomic information from the lower urinary tract is relayed to supraspinal structures. Information about supraspinal (inter)connections and their function in micturition control is still fragmentary. The control mechanisms which terminate voiding are not totally clear. Moreover, the role of the pelvic floor musculature in the control of the lower urinary tract is probably underestimated. The flow charts presented in this paper contribute to the future design of a single complete qualitative model representing the general central and peripheral nervous connections and control mechanisms. Such a model would provide an approach for future research in neuromodulation and neurostimulation of the uropoetic system and a reduced version could be used for quantitative modelling, e.g. in neural network simulations.

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Distribution of Α‐ and Β‐adrenoceptors in Human Urinary Bladder

Cited by 131 publications

References 19 publications

The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibers supplying the porcine urinary bladder wall

The influence of botulinum toxin type A (BTX) on the immunohistochemical characteristics of noradrenergic and cholinergic nerve fibers supplying the porcine urinary bladder wall

Nicergoline in the treatment of neuropathic bladder dysfunction: a preliminary report

Neuronal circuitry of the lower urinary tract; central and peripheral neuronal control of the micturition cycle

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