Diuretic effects and urinary electrolyte excretion induced by Aspidosperma subincanum Mart. and the involvement of prostaglandins in such effects

Ribeiro, Emmeline Flor; Reis, Carolina de Fátima; Carvalho, Flávio Silva de; Abreu, João Pedro Silva; Arruda, Andréa F.; Garrote, Clévia Ferreira Duarte; Rocha, Matheus Lavorenti

doi:10.1016/j.jep.2015.01.023

Cited by 13 publications

(12 citation statements)

References 24 publications

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“…This suggested that CSSD may have diuretic properties. Diuretics act by diminishing sodium reabsorption at different sites in the nephron, thereby increasing urinary sodium/water losses, decreasing blood volume and hence BP (Ribeiro et al, 2015). Studies have shown that phytosterols may act as adjuvants in the prevention and treatment of cardiovascular diseases by reducing blood cholesterol levels (Racette et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Fractionation and bioassay-guided isolation of antihypertensive components of Senecio serratuloides

et al. 2020

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Senecio serratuloides commonly referred to as "two day cure" is used in folk medicine for treating hypertension and wounds in South Africa. This study was aimed at isolating and testing the antihypertensive effects of bioactive compounds from S. serratuloides. Senecio serratuloides was serially extracted using solvents of increasing polarity. Phytochemical analysis, antioxidant capacity and antihypertensive properties of fractions were investigated. Bioactive compounds were isolated from ethyl acetate and methanol fractions, their antihypertensive effects and effect on urine norepinephrine concentration were determined. Ethyl acetate and methanol fractions had all eight phytochemicals tested, better antioxidant capacity and significantly (p < 0.001) prevented the increase in blood pressure induced by N ω -Nitro-L-arginine methyl ester hydrochloride. The isolated bioactive compounds were phytosteroids and Estran-3-one, 17-(acetyloxy)-2-methyl-, (2à,5à,17á)which was isolated from methanol fraction had significantly (p < 0.001) better antihypertensive effects through the 4-h period of the study. Senecio serratuloides may be a potential source of antihypertensive lead compounds.

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Section: Discussionmentioning

confidence: 99%

Fractionation and bioassay-guided isolation of antihypertensive components of Senecio serratuloides

et al. 2020

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“…These findings showed that EEAS may be a hazard in high doses, however, a previous study using lower doses of A. subincanum extract for 30 days (5 and 100 mg/kg), showed no signs of toxicity in the organ tissues (Santos et al, 2009). To date, a few studies were performed to test the biological activities of A. subincanum in vivo, and it is important to note that this plant species exhibited dose-dependent hypotensive effects in low doses (0.03 -33 mg/kg) (Bernardes et al, 2013) and diuretic effects at 120 mg/kg dose (Ribeiro et al, 2015). These doses are below the risk range present in this study.…”

Section: Discussionmentioning

confidence: 74%

Pharmacognostic assessment and pre-clinical toxicity of ethanolic extract from Aspidosperma subincanum Mart. stem bark (Guatambu)

Alves

Silva

Parente

et al. 2021

RSD

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Ethnopharmacological relevance: Diabetes mellitus is a disease that affects approximately 10% of the world population. As it is a chronic disease, several patients search for alternatives to the traditional allopathic treatment, such as medicinal plants. In Brazil, the Aspidosperma subincanum (Guatambu) is one of the vegetal species commercialized in open markets used for diabetes popular treatment. Objective: To perform the phytochemical prospection and pre-clinical assessment of the ethanolic extract from stem bark of A. subincanum bark (EEAS). Material and methods: A. subincanum stem barks were collected in state of Goiás, Brazil and the EEAS was obtained by cold maceration. The phytochemical prospection was performed and acute and subacute toxicity assessments were performed according to OECD guidelines. Results: Phytochemical prospection identified the presence of steroids, triterpenes, saponins, tannins, alkaloids, coumarins, and resins. The acute toxicity showed no death in EEAS doses administered intraperitoneally (500, 1000, and 2000 mg/kg) and orally (5000 mg/kg). The subacute toxicity showed signs of nephrotoxicity, hepatotoxicity, and lung damages in the two highest doses tested (250, 250 mg/kg) in a dose-dependent way. However, the satellite group showed reversion of the lesions after 30 days of EEAS interruption. Conclusion: The acute toxicity of EEAS suggests an LD50 > 5000 mg/kg. The oral use of EEAS during a short period (30 days) or more can be hazardous at doses similar to that tested in this study and may represent a risk for those who consume this kind of extract as a medicinal plant.

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“…It is known that drugs with diuretic action such as loop diuretics and thiazides, either alone or in combination with other drugs are used for the treatment of various disorders such as hypertension, nephritis, chronic renal failure, eclampsia and heart failure, especially by increasing urine flow and renal sodium excretion (Ribeiro et al, 2015). Despite their high efficiency, many diuretics have been associated with undesirable side effects, including electrolyte imbalance, metabolic alkalosis, hyperuricemia, development of new-onset diabetes metabolic alterations, and activation of the renin-angiotensin-neuroendocrine systems (Kateel et al, 2014;Ribeiro et al, 2015). Hence, there is a need for new diuretics with lower potential for adverse effects, such as the plant-based substances which are considered to be relatively safe.…”

Section: Discussionmentioning

confidence: 99%

In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat

Bouaziz

Khennouf

Zarga

et al. 2019

Bangladesh J Pharmacol

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In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat BJP Thus, much attention has been paid to the study of medicinal plants, including the screening of natural bioactive compounds such as phenolic compounds with the ability to cure, prevent the progression of many diseases (Yadegarinia et al., 2006) and the exploration of traditional medicines may reveal new treatment options to increase the therapeutic arsenal by the discovery of novel medicines and to offer lower cost alternatives in developing countries that increasingly AbstractThe objective of this study was to evaluate the in vitro anti-oxidant, hypotensive and the diuretic activities of Origanum glandulosum leaves in rat. Chemical analysis revealed the isolation of katuranin and 5-isopropyl-3methylphenol. Ethyl acetate extract possessed highest scavenging activity against DPPH and hydroxyl radicals. Intravenous administration of extracts (0.04 to 12 mg/kg body weight) dose-dependently decreased the blood pressure (systolic, diastolic and mean) of the anesthetized rat. Methanol extract showed dose-dependent diuretic activity by increasing the urine output (77%) and the urinary excretion of sodium and potassium. In conclusion, this study supports the use of O. glansulosum in traditional medicine as hypotensive and diuretic agents. Article Info

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Diuretic effects and urinary electrolyte excretion induced by Aspidosperma subincanum Mart. and the involvement of prostaglandins in such effects

Cited by 13 publications

References 24 publications

Fractionation and bioassay-guided isolation of antihypertensive components of Senecio serratuloides

Fractionation and bioassay-guided isolation of antihypertensive components of Senecio serratuloides

Pharmacognostic assessment and pre-clinical toxicity of ethanolic extract from Aspidosperma subincanum Mart. stem bark (Guatambu)

In vitro anti-oxidant, hypotensive and diuretic activities of Origanum glandulosum in rat

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