Diurnal drooling in Chinese patients with Parkinson's disease

Ou, Ruwei; Guo, Xiaoyan; Wei, Qianqian; Cao, Bei; Yang, Jing; Song, Wei; Chen, Ke; Zhao, Bi; Chen, Xueping

doi:10.1016/j.jns.2015.04.007

Cited by 18 publications

(42 citation statements)

References 28 publications

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“…Treatment of drooling with BNT-A injections has an effect on the amount and condition of saliva and leads to the changes of oral environment and health. Our results are in line with previous studies showing that BNT-A reduces drooling [18,[31][32][33][34]. There are no data from earlier studies on saliva composition and microbial changes after BNT-A.…”

Section: Discussionsupporting

confidence: 92%

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Saliva changes in Parkinson’s disease patients after injection of Botulinum neurotoxin type A

et al. 2018

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Patients with Parkinson's disease (PD) are compromised by poor oral condition due to oropharyngeal bradykinesia, dysphagia, and the side effects of treatment. Intrasalivary gland injections of Botulinum neurotoxin type A (BNT-A) have been known to treat sialorrhea effectively in these patients. However, the decreased amount of saliva reduces self-cleaning ability that deteriorates oral hygiene and increases dental caries. The aim of this study was to determine the changes in the oral microflora and saliva in patients with PD treated for sialorrhea by means of sonography-controlled BNT-A injections into the bilateral parotid and submandibular glands. Altogether, 38 persons participated in the study: 12 PD patients who were injected with BNT-A for treatment of sialorrhea and passed salivary tests before and 1 month after the injections; and 13 PD patients and 13 healthy subjects who were not injected with BNT-A and passed salivary tests once. The condition of oral health was measured by the amount of saliva, salivary flow rate, and salivary composition. A good outcome with a significant decrease in salivary flow rate occurred at 1-month follow-up in the BNT-A-treated group while no significant change was found in salivary composition. BNT-A treatment did not change the Streptococcus mutans levels in saliva but there was statistically significant increase in levels of Lactobacilli. BNT-A injections can effectively treat sialorrhea while considering the change of oral microflora, and the patients should be under dentists' care more frequently. EudraCT clinical trial number: 2015-000682-30.

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Section: Discussionsupporting

confidence: 92%

“…The prevalence of drooling in PD patients ranges widely, from 10 to 84% [10,16]. Our study showed that PD patients who experienced drooling were statistically more often on levodopa treatment supporting the findings by Ou et al [31].…”

Section: Discussionsupporting

confidence: 89%

Saliva changes in Parkinson’s disease patients after injection of Botulinum neurotoxin type A

et al. 2018

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“…They found that 18% of the sample of 419 PD patients had dysphagia. Different values of prevalence were found in the study of Ou et al [7], which had 36.3% of the PD patients with dysphagia, of a total the 518 PD patients assessed by using a range of questionnaires, as the "Unified PD Rating Scale (UPDRS) part III". In the same way, Walker et al [8] reported a prevalence of 32.0% of dysphagia in the sample of 72 PD patients.…”

Section: Prevalence Of Dysphagia In Parkinson's Diseasementioning

confidence: 91%

“…In the last 5 years, the prevalence of dysphagia in Parkinson's disease (PD) has been reported with a wide range, from 11% to 100% [4][5][6][7][8][9][10][11][12][13][14][15][16]. The procedures used to assess the presence of dysphagia and its severity it also differs in studies.…”

Section: Prevalence Of Dysphagia In Parkinson's Diseasementioning

confidence: 99%

“…Additionally of the difficulty to swallowing, these patients have a faster excretion of saliva, leading to easier saliva retention in the mouth or sialorrhea (drooling) [24,25]. Ou et al [7] reported that 52.7% of the PD patients complained about sialorrhea, and this symptom was more frequent in patients with a late-onset of the disease. Also, Kalf et al [25] observed that the patients, in most advanced stages of PD, with sialorrhea attempted to compensate the excess of saliva increasing the swallowing frequency.…”

Section: Non-motors Aspects Of Dysphagia In Parkinson's Diseasementioning

confidence: 99%

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Dysphagia in Parkinson’s disease: Prevalence, Impact and Management Challenges

Luchesi¹,

Toledo²,

Mourão³

2017

JOENTR

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The aim of this review is to present an update of the prevalence, impact and management challenges of dysphagia in Parkinson's disease. In the last 5 years, the prevalence of dysphagia in Parkinson's disease (PD) has been reported with a wide range of values in the literature. The dysphagia prevalence ranged from 11% to 100% of the patients with PD. This variation, generally, depended on the disease stage and the procedure of swallowing assessment. In the management of dysphagia, compensatory techniques, rehabilitation exercises and deep-brain stimulation have been conducted. Despite of the lack of high scientific evidences of efficiency of the majority of these interventions, the positive aspects and benefits are described in the actual literature. Moreover, this review paper discuss about the importance of the dysphagia assessment and treatment in the best timing to prevent complications, as pulmonary and nutritional impairment, and to improve quality of life.

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