Diverging prognostic impacts of hypoxic markers according to NSCLC histology

Andersen, Sigve; Eilertsen, Marte; Dønnem, Tom; Al-Shibli, Khalid; Al-Saad, Samer; Busund, Lill-Tove; Bremnes, Roy M.

doi:10.1016/j.lungcan.2010.10.006

Cited by 40 publications

(50 citation statements)

References 51 publications

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“…Numerous studies documented that the hypoxia microenvironment was able to enhance tumor progression [9,15]. A growing body of evidence demonstrated that there is a high correlation between hypoxia and lung cancer metastasis and poor prognosis [16,17]. Unfortunately, the OLV anesthesia technique, widely used during lung cancer surgery, aggravates hypoxia, which promotes the invasiveness of lung cancer [11].…”

Section: Discussionmentioning

confidence: 99%

Sevoflurane suppresses hypoxia-induced growth and metastasis of lung cancer cells via inhibiting hypoxia-inducible factor-1α

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Sevoflurane suppresses hypoxia-induced growth and metastasis of lung cancer cells via inhibiting hypoxia-inducible factor-1α

et al. 2015

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“…The slides were assessed independently by 2 investigators, who were unaware of the clinical data; any disagreement was resolved by discussion. The staining intensity and distribution were evaluated according to the method of Choi et al, 19 Tanaka et al, 20 and Andersen et al, 21 to determine the immunoexpression in stroma or parenchymal cells, the cellular location of this staining (membrane, cytoplasm, nucleus), and location at the periphery or in the center of the tumor islands. Staining intensity was evaluated using scores of 0 to 2, with 0 indicating no staining, 1, weak staining, and 2, strong staining.…”

Section: Methodsmentioning

confidence: 99%

“…Cases in which more than 10% of cells were stained were defined as positive. 21,22 The staining distribution was analyzed quantitatively using the following criteria adapted from Lee et al 23 : focal (<50% of immunostained cells) and diffuse (>50% of immunostained cells).…”

Section: Methodsmentioning

confidence: 99%

Distribution of Hypoxia-Inducible Factor-1α and Glucose Transporter-1 in Human Tongue Cancers

Vasconcelos

Oliveira

et al. 2015

Journal of Oral and Maxillofacial Surgery

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Purpose: Oral squamous cell carcinomas have the potential for rapid and unlimited growth. Therefore, hypoxic tissue areas are common in these malignant tumors and contribute to cancer progression, therapy resistance, and poor outcomes. The aim of the present study was to analyze the gene product distribution of hypoxia-inducible factor-1a (HIF-1a) and glucose transporter-1 (GLUT-1) in cases of tongue squamous cell carcinoma (TSCC) and to identify a preliminary correlation between these proteins and clinical staging and Brynes's histologic grading system (HGS). Materials and Methods:The sample included 57 cases of TSCC. Histologic sections of 3 mm were submitted to the immunoperoxidase method and semiquantitative analysis. The association between HIF-1a and GLUT-1 expression in TSCC and the clinical stage and the HGS of Bryne (1998) was evaluated using the c 2 test, with the significance level set at 0.05 (a = 0.05).Results: HIF-1a was mainly expressed in the nucleus/cytoplasm of neoplastic cells, most specimens exhibited diffuse staining in neoplastic cells (84.2%), and focal staining was only observed in perinecrotic areas (15.8%). GLUT-1 was expressed in the cytoplasm and membrane of malignant cells, and diffuse staining was observed in all cases. The intensity of HIF-1a expression correlated significantly with clinical stage (P = .011) and HGS (P = .002). A significant association was observed between the distribution of HIF-1a expression and metastasis (P = .040). Immunoexpression of GLUT-1 correlated significantly with clinical stage (P = .002) and HGS (P = .000). GLUT-1 expression in the peripheral island was predominant in most low-grade tumors (78.6%); in the high-grade cases, the expression prevailed in the location center/periphery (55.8%). Comparison of the location of the tumor island in the different histologic grades showed a statistically significant difference (P = .025).

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Section: Introductionmentioning

confidence: 99%

“…In patients with lung adenocarcinoma, only a few parameters are described as a prognostic factors such as stage of disease, tumor metabolism, high GLUT1 expression and performance status (de Geus-Qei et al, 2007;Andersen et al, 2011).Serum total proteins contain albumin, globulins and other inflammatory proteins such as C-reactive protein (CRP), interleukins and tumor necrosis factors (McPherson et al, 2006). Albumin and globulins play a pivotal role in the inflammatory process .…”

mentioning

confidence: 99%

Albumin-globulin Ratio for Prediction of Long-term Mortality in Lung Adenocarcinoma Patients

Duran¹,

İnanç²,

Karaca³

et al. 2014

Asian Pacific Journal of Cancer Prevention

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Asian Pac J Cancer Prev, 15 (15), [6449][6450][6451][6452][6453] Introduction Non-small cell lung cancer (NSCLC), which includes a broad range of lung tumors encompassing squamous cell carcinomas and adenocarcinomas as the major subtypes, is the most common cause of cancer related death (Jemal et al., 2010). In patients with lung adenocarcinoma, only a few parameters are described as a prognostic factors such as stage of disease, tumor metabolism, high GLUT1 expression and performance status (de Geus-Qei et al., 2007;Andersen et al., 2011).Serum total proteins contain albumin, globulins and other inflammatory proteins such as C-reactive protein (CRP), interleukins and tumor necrosis factors (McPherson et al., 2006). Albumin and globulins play a pivotal role in the inflammatory process . Serum albumin is also an objective parameter that reflects the degree of long-term nutrition status (Laky et al., 2007

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Diverging prognostic impacts of hypoxic markers according to NSCLC histology

Cited by 40 publications

References 51 publications

Sevoflurane suppresses hypoxia-induced growth and metastasis of lung cancer cells via inhibiting hypoxia-inducible factor-1α

Sevoflurane suppresses hypoxia-induced growth and metastasis of lung cancer cells via inhibiting hypoxia-inducible factor-1α

Distribution of Hypoxia-Inducible Factor-1α and Glucose Transporter-1 in Human Tongue Cancers

Albumin-globulin Ratio for Prediction of Long-term Mortality in Lung Adenocarcinoma Patients

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