Diverse pathological implications of YKL-40: Answers may lie in ‘outside-in’ signaling

Prakash, Mansi; Bodas, Manish; Prakash, Divya; Nawani, Neelu; Khetmalas, Madhukar; Mandal, Abul; Eriksson, Cecilia

doi:10.1016/j.cellsig.2013.03.016

Cited by 79 publications

(67 citation statements)

References 81 publications

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“…Currently YKL-40 is being suggested as a biomarker in inflammatory pulmonary, cardiovascular, metabolic, joint-related, hepatic and neurologic disorders [64,65]. High levels of YKL-40 in serum, bronchoalveolar lavage fluid, or sputum were found in various pulmonary disorders.…”

Section: Chitinase-like Proteinsmentioning

confidence: 99%

Perspectives for Monocyte/Macrophage-Based Diagnostics of Chronic Inflammation

Kzhyshkowska¹,

Gudima

Moganti

et al. 2016

Transfus Med Hemother

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Low-grade chronic inflammation underlies the development of the most dangerous cardiometabolic disorders including type 2 diabetes and its vascular complications. In contrast to acute inflammation induced by bacteria and viruses, chronic inflammation can be driven by abnormal reaction to endogenous factors, including Th2 cytokines, metabolic factors like advanced glycation end products (AGEs), modified lipoproteins, or hyperglycemia. The key innate immune cells that recognize these factors in blood circulation are monocytes. Inflammatory programming of monocytes which migrate into tissues can, in turn, result into generation of tissue macrophages with pathological functions. Therefore, determination of the molecular and functional phenotype of circulating monocytes is a very promising diagnostic tool for the identification of hidden inflammation, which can precede the development of the pathology. Here we propose a new test system for the identification of inflammatory programming of monocytes: surface biomarkers and ex vivo functional system. We summarize the current knowledge about surface biomarkers for monocyte subsets, including CD16, CCR2, CX3CR1, CD64, stabilin-1 and CD36, and their association with inflammatory human disorders. Furthermore, we present the design of an ex vivo monocyte-based test system with minimal set of parameters as a potential diagnostic tool for the identification of personalized inflammatory responses.

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Section: Chitinase-like Proteinsmentioning

confidence: 99%

Perspectives for Monocyte/Macrophage-Based Diagnostics of Chronic Inflammation

Kzhyshkowska¹,

Gudima

Moganti

et al. 2016

Transfus Med Hemother

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“…Hence, findings based on human samples are very important in order to understand normal brain development and disorders of the central nervous system. So far, YKL-40 has been described particularly in diverse pathological conditions and promoted as a factor with profound implications for both diagnostic and therapeutic applications (Prakash et al 2013), whereas the general role of YKL-40 in developmental biology has been largely ignored, with a few exceptions (Johansen et al 2007;Brøchner et al 2012). In order to elucidate its possible functions during brain development, we have focused on YKL-40 protein and its mRNA expression in human embryonic and fetal forebrain.…”

Section: Ykl-40 In the Early Developing Human Forebrainmentioning

confidence: 99%

Brain Barriers and a Subpopulation of Astroglial Progenitors of Developing Human Forebrain Are Immunostained for the Glycoprotein YKL-40

Bjørnbak

Brøchner

Larsen

et al. 2014

J Histochem Cytochem.

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SummaryYKL-40, a glycoprotein involved in cell differentiation, has been associated with neurodevelopmental disorders, angiogenesis, neuroinflammation and glioblastomas. We evaluated YKL-40 protein distribution in the early human forebrain using double-labeling immunofluorescence and immunohistochemistry. Immunoreactivity was detected in neuroepithelial cells, radial glial end feet, leptomeningeal cells and choroid plexus epithelial cells. The subpial marginal zone was YKL-40-positive, particularly in the hippocampus, from an early beginning stage in its development. Blood vessels in the intermediate and subventricular zones showed specific YKL-40 reactivity confined to pericytes. Furthermore, a population of YKL-40-positive, small, rounded cells was identified in the ventricular and subventricular zones. Real-time quantitative RT-PCR analysis showed strong YKL-40 mRNA expression in the leptomeninges and the choroid plexuses, and weaker expression in the telencephalic wall. Immunohistochemistry revealed a differential distribution of YKL-40 across the zones of the developing telencephalic wall. We show that YKL-40 is associated with sites of the brain barrier systems and propose that it is involved in controlling local angiogenesis and access of peripheral cells to the forebrain via secretion from leptomeningeal cells, choroid plexus epithelium and pericytes. Furthermore, we suggest that the small, rounded, YKL-40-positive cells represent a subpopulation of astroglial progenitors, and that YKL-40 could be involved in the differentiation of a particular astrocytic lineage. (J Histochem Cytochem 62:369-388, 2014)

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“…YKL-40 is implicated in fibroblasts and chondrocytes proliferation, macrophage differentiation, inflammation and extracellular matrix remodeling [9]. Recent studies have found aberrant YKL-40 elevated expression in cancer of various organs [10], so it may be used as a recent prognostic biomarker for cancer patients.…”

Section: Introductionmentioning

confidence: 99%

Prognostic and Clinicopathological Value of the Expression of FOXC2 & YKL-40 in Carcinoma of the Breast, an Immunohistochemical Study

Fouad¹,

Mahmoud²,

Ahmed³

et al. 2018

ABCR

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Background: Breast cancer is considered the commonest and the most fatal female cancer worldwide. There is to an urgent need for discovering recent therapies to identify patient prognosis and improve treatment strategies. Fork-head Box C2 (FOXC2) is a transcription factor which is a key regulator of cancer stem cells (CSC) properties and epithelial mesenchymal transition (EMT) e.g. cancer initiation, metastatic capacity, and resistance to chemotherapy. FOXC2 roles in CSCs properties and EMT regulation in breast cancer needs detailed studies. YKL-40 is known as chitinase-3-like-1 belongs to a family of mammalian proteins that have an amino acid sequence which is similar to the 18-glycosyl hydrolase bacterial chitinases group. Recent studies have found aberrant YKL-40 elevated expression in cancer of various organs, so it may be used as a recent prognostic biomarker for patients with breast cancer. Former researchers have assessed the expression of FOXC2 & YKL-40 separately in cancer patients and relations to prognosis of patients; however, no studies assessed them together in breast cancer patients and the previous results were inconclusive. Accordingly, our study aimed at evaluation of immunohistochemical expressions of FOXC2 & YKL-40 in carcinoma of the breast in a trial to clarify the relation among their expressions, clinicopathological parameters and recurrence of the disease after successive therapy and patients' prognosis. Methods: we have evaluated expressions of FOXC2 & YKL-40 in sections from 50 paraffin blocks of carcinoma of the breast using

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Diverse pathological implications of YKL-40: Answers may lie in ‘outside-in’ signaling

Cited by 79 publications

References 81 publications

Perspectives for Monocyte/Macrophage-Based Diagnostics of Chronic Inflammation

Perspectives for Monocyte/Macrophage-Based Diagnostics of Chronic Inflammation

Brain Barriers and a Subpopulation of Astroglial Progenitors of Developing Human Forebrain Are Immunostained for the Glycoprotein YKL-40

Prognostic and Clinicopathological Value of the Expression of FOXC2 & YKL-40 in Carcinoma of the Breast, an Immunohistochemical Study

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Diverse pathological implications of YKL-40: Answers may lie in ‘outside-in’ signaling

Cited by 79 publications

References 81 publications

Perspectives for Monocyte/Macrophage-Based Diagnostics of Chronic Inflammation

Perspectives for Monocyte/Macrophage-Based Diagnostics of Chronic Inflammation

Brain Barriers and a Subpopulation of Astroglial Progenitors of Developing Human Forebrain Are Immunostained for the Glycoprotein YKL-40

Prognostic and Clinicopathological Value of the Expression of FOXC2 &amp; YKL-40 in Carcinoma of the Breast, an Immunohistochemical Study

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Prognostic and Clinicopathological Value of the Expression of FOXC2 & YKL-40 in Carcinoma of the Breast, an Immunohistochemical Study