Diversification of muscle types in Drosophila embryos

Junion, Guillaume; Jagla, Krzysztof

doi:10.1016/j.yexcr.2021.112950

Cited by 9 publications

(6 citation statements)

References 84 publications

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“…Expression of twi has been regarded as a molecular marker for embryonic stem cell-like adult muscle precursor (AMP) cells 38 . twi is a transcription factor, whose expression ceases with the beginning of the AMPs differentiation, which in turn coincides with an onset of expression of a number of terminal differentiation and muscle identity genes, including Tm2 , mhc , and gel 39 , 40 ; their orthologs are highly expressed in the AgMM cells. A time-course analysis of transcriptional changes during immortalisation of Drosophila embryonic myocytes revealed a small cluster of genes with an expression profile highly correlated to that of twi 40 , among them kon and nvy , A. gambiae orthologs of which have moderate to high expression in AgMM cells.…”

Section: Resultsmentioning

confidence: 99%

Establishment and a comparative transcriptomic analysis of a male-specific cell line from the African malaria mosquito Anopheles gambiae

Krzywińska

Ferretti

Krzywinski

2022

Sci Rep

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Cell lines allow studying various biological processes that may not be easily tractable in whole organisms. Here, we have established the first male-specific cell line from the African malaria mosquito, Anopheles gambiae. The cells, named AgMM and derived from the sex-sorted neonate larvae, were able to undergo spontaneous contractions for a number of passages following establishment, indicating their myoblast origin. Comparison of their transcriptome to the transcriptome of an A. gambiae-derived Sua5.1 hemocyte cells revealed distinguishing molecular signatures of each cell line, including numerous muscle-related genes that were highly and uniquely expressed in the AgMM cells. Moreover, the AgMM cells express the primary sex determiner gene Yob and support male sex determination and dosage compensation pathways. Therefore, the AgMM cell line represents a valuable tool for molecular and biochemical in vitro studies of these male-specific processes. In a broader context, a rich transcriptomic data set generated in this study contributes to a better understanding of transcribed regions of the A. gambiae genome and sheds light on the biology of both cell types, facilitating their anticipated use for various cell-based assays.

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Section: Resultsmentioning

confidence: 99%

Establishment and a comparative transcriptomic analysis of a male-specific cell line from the African malaria mosquito Anopheles gambiae

Krzywińska

Ferretti

Krzywinski

2022

Sci Rep

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“…While specific molecular signatures have been identified for satellite cells associated to specific adult muscles types ( Evano et al, 2020 ), developmental rules establishing stereotypical vertebrate muscle patterns and shapes only begin to be elucidated ( Besse et al, 2020 ). In contrast, the molecular genetic basis of stereotypical muscle patterns has been highly investigated in the dipteran insect Drosophila ( Bate, 1990 ; Bate, 1993 ; Dobi et al, 2015 ; Deng et al, 2017 ; Junion and Jagla, 2022 ).…”

Section: Alary Muscle Founder Cellsmentioning

confidence: 99%

Insights and perspectives on the enigmatic alary muscles of arthropods

Bataillé,

Lebreton,

Boukhatmi

et al. 2024

Front. Cell Dev. Biol.

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Three types of muscles, cardiac, smooth and skeletal muscles are classically distinguished in eubilaterian animals. The skeletal, striated muscles are innervated multinucleated syncytia, which, together with bones and tendons, carry out voluntary and reflex body movements. Alary muscles (AMs) are another type of striated syncytial muscles, which connect the exoskeleton to the heart in adult arthropods and were proposed to control hemolymph flux. Developmental studies in Drosophila showed that larval AMs are specified in embryos under control of conserved myogenic transcription factors and interact with excretory, respiratory and hematopoietic tissues in addition to the heart. They also revealed the existence of thoracic AMs (TARMs) connecting to specific gut regions. Their asymmetric attachment sites, deformation properties in crawling larvae and ablation-induced phenotypes, suggest that AMs and TARMs could play both architectural and signalling functions. During metamorphosis, and heart remodelling, some AMs trans-differentiate into another type of muscles. Remaining critical questions include the enigmatic modes and roles of AM innervation, mechanical properties of AMs and TARMS and their evolutionary origin. The purpose of this review is to consolidate facts and hypotheses surrounding AMs/TARMs and underscore the need for further detailed investigation into these atypical muscles.

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“…Among these tissues, the tendons ensure that the correct transmission of muscle contraction force is applied to the skeleton. Although Drosophila melanogaster is an established model used to better understand the cellular and molecular events in the conserved myogenesis process ( Deng et al, 2017 ; Laurichesse and Soler, 2020 ; Boukhatmi, 2021 ; Luis and Schnorrer, 2021 ; Junion and Jagla, 2022 ; Rout et al, 2022 ), some studies have also highlighted common features in the development of muscle attachment sites between vertebrates and invertebrates ( Schnorrer and Dickson, 2004 ; Schweitzer et al, 2010 ; Hasson et al, 2017 ; Valdivia et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Developmental origin of tendon diversity in Drosophila melanogaster

et al. 2023

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Myogenesis is a developmental process that is largely conserved in both Drosophila and higher organisms. Consequently, the fruit fly is an excellent in vivo model for identifying the genes and mechanisms involved in muscle development. Moreover, there is growing evidence indicating that specific conserved genes and signaling pathways govern the formation of tissues that connect the muscles to the skeleton. In this review, we present an overview of the different stages of tendon development, from the specification of tendon progenitors to the assembly of a stable myotendinous junction across three different myogenic contexts in Drosophila: larval, flight and leg muscle development. We underline the different aspects of tendon cell specification and differentiation in embryo and during metamorphosis that result into tendon morphological and functional diversity.

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Diversification of muscle types in Drosophila embryos

Cited by 9 publications

References 84 publications

Establishment and a comparative transcriptomic analysis of a male-specific cell line from the African malaria mosquito Anopheles gambiae

Establishment and a comparative transcriptomic analysis of a male-specific cell line from the African malaria mosquito Anopheles gambiae

Insights and perspectives on the enigmatic alary muscles of arthropods

Developmental origin of tendon diversity in Drosophila melanogaster

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