Diversité étiologique des vaginites

Bohbot, Jean-Marc; Sednaoui, Patrice; Verrière, François; Achhammer, I.

doi:10.1016/j.gyobfe.2011.08.001

Cited by 15 publications

(5 citation statements)

References 9 publications

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“…29 Studies conducted by Bohbot et al (2012) and Kamga et al (2017) in pregnant women reported prevalence of bacterial vaginosis of 30% and 26.02% respectively. 30,31 The prevalence of bacterial vaginosis from these two authors are relatively higher than the finding of this study. This difference can be justified by a larger sample size and moreover pregnant women have a decrease in their immunity, which exposes them to infections.…”

Section: Prevalence Of Genital Infectionscontrasting

confidence: 68%

Prevalence of bacterial vaginosis due to Gardnerella species, vaginal candidiasis and trichomoniasis: Epidemiological aspect in women and adolescent girls in Yaoundé, Cameroon

Djoulde

2024

IJCSMR

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Vaginal infections are a health problem due to their high frequency in our healthcare facilities. The objective of this work was to evaluate the prevalence of vaginal candidiasis, bacterial vaginosis due to the Gardnerella species and trichomoniasis, and study the associated risk factors among women and adolescents in the city of Yaoundé.Trichomonas vaginalis was identified by searching for a viable trophozoite by spreading leucorrhoea between slide and slide cover in physiological water. Candida species was found by culture on Sabouraud Chloramphenicol agar. Bacterial vaginosis was revealed according to the Thomasson classification. Gardnerella species was identified by Gram stain.The finding were: 52.37% of women had vaginal infections. Bacterial vaginosis had a prevalence of 32.92% and gardnerellosis represented 20.66% of vaginal infections, while candidiasis amounted to 16.66%. 0.79% of women suffered from trichomoniasis. The population most affected by bacterial vaginosis due to Gardnerella species was between 25 and 34 years old (13.49%).. University level women and adolescents girls were more exposed to bacterial vaginosis due to Gardnerella species (15.87%) than high school level women and adolescents girls (3.18% and 2.38% respectively). Further studies on a larger sample of patients are required to further appreciate the epidemiology of vaginal infections.

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Section: Prevalence Of Genital Infectionscontrasting

confidence: 68%

Prevalence of bacterial vaginosis due to Gardnerella species, vaginal candidiasis and trichomoniasis: Epidemiological aspect in women and adolescent girls in Yaoundé, Cameroon

Djoulde

2024

IJCSMR

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“…The etiological diversity of vaginitis is well established. It was found in the distribution of pathogens incriminated in this study that included 169 patients on the basis of a clinical presentation suggestive of infectious vaginitis [6]. After microbiological analysis of vaginal samples, the infectious etiology of vaginitis represented nearly 70% of cases.…”

Section: Discussionmentioning

confidence: 81%

“…These samples were taken using sterile swabs at the lateral or anterior vaginal cul-de-sac and sent to a centralized microbiology laboratory in semisolid transport medium (Alfred Fournier Institute Laboratory, Paris). Microbiological analyses, performed according to the protocol described by Bohbot et al, 2011, were interpreted in blinded fashion [6]. Microbiological results were obtained between 3 and 5 days.…”

Section: Microbiological Evaluationmentioning

confidence: 99%

Nystatin-Neomycin-Polymyxin B Combination: Efficacy and Tolerance as 1st-Line Local Treatment of Infectious Vaginitis

Bohbot¹,

Sednaoui²,

Verrière³

2014

OJOG

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Objective: To evaluate the efficacy and tolerance of a local treatment combining two antibacterials and one antifungal in patients with a clinical presentation suggesting infectious vaginitis. Patients and methods: 169 patients presenting with clinical criteria for vaginitis were included in an open, multicenter trial. Vaginal samples were taken for microbiological analyses and a triple-combination product of nystatin, neomycin and polymyxin B was then started as local treatment, without waiting for the test results. The treatment was continued with the usual dosage (1 vaginal capsule at bedtime for 12 days) for vaginal infections in the scope of the combination product with approved labeling. A second vaginal sample was performed at the end of the treatment. The main efficacy criterion was the clinical success rate (cure or improvement of the clinical signs and symptoms) according to the investigator. Results: 93 patients were included in the efficacy population. Non-exclusively fungal vaginitis (strictly bacterial or bacterial + fungal) represented 31.2% of the cases. The clinical success rate was 97.8% according to the investigator and 95.7% according to the patients. The microbiological success rate was 81.3%, with no differences between etiologies (Candida spp., bacteria or both). The combination product was well-tolerated, despite the local inflammation before treatment. Discussion and conclusion: Given the etiological diversity of vaginitis, this trial supports the efficacy of a triple-combination product (nystatin, neomycin, polymyxin B) as a first-line local treatment of Candida, bacterial or mixed vaginitis.

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“…Unlike antiseptics, which have a broad spectrum activity on all microorganisms, antibiotics specifically target bacteria and have a fairly narrow spectrum of activity. Around 25% of cases are mixed vaginitis, warranting the use of topical antimicrobial combinations such as antifungal agents and antibiotics [13].…”

Section: Introductionmentioning

confidence: 99%

Topical Treatment of Infectious Vaginitis: Effects of Antibiotic, Antifungal and Antiseptic Drugs on the Growth of Normal Vaginal <i>Lactobacillus</i> Strains

Neut

Verrière²,

Nelis³

et al. 2015

OJOG

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Objectives: The balance of the vaginal ecosystem depends on lactobacilli whose biofilm protects against microorganisms that are not normally present or are subdominant in vaginal flora. Vaginal infection treatments should eliminate pathogens while preserving the Lactobacillus flora to prevent relapse or recurrence. The objective of this study was to determine the sensitivity of lactobacilli to antiseptics, antibiotics and antifungal agents used, alone or in combination, in the topical treatment of infectious vaginitis. Materials and Methods: The minimum inhibitory concentration (MIC) of 15 active ingredients and the minimum inhibitory dilution (MID) of 17 pharmaceuticals products were determined for three main Lactobacillus strains (L. crispatus, L. gasseri and L. jensenii). Results: The MICs of the antibiotics and antifungal agents were above their critical concentrations in the three strains, contrary to the antiseptics. According to their MID, some pharmaceutical products, especially combinations, inhibit the growth of one or more strains at concentrations that can be found in the vaginal mucosa after application at the usual dosage. Conclusions: Certain topical anti-infective drugs may interfere with the growth of lactobacilli, worsening the vaginal flora imbalance. Maintaining vaginal flora balance should be a selection criterion when choosing an anti-infective therapy.

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Diversité étiologique des vaginites

Cited by 15 publications

References 9 publications

Prevalence of bacterial vaginosis due to Gardnerella species, vaginal candidiasis and trichomoniasis: Epidemiological aspect in women and adolescent girls in Yaoundé, Cameroon

Prevalence of bacterial vaginosis due to Gardnerella species, vaginal candidiasis and trichomoniasis: Epidemiological aspect in women and adolescent girls in Yaoundé, Cameroon

Nystatin-Neomycin-Polymyxin B Combination: Efficacy and Tolerance as 1st-Line Local Treatment of Infectious Vaginitis

Topical Treatment of Infectious Vaginitis: Effects of Antibiotic, Antifungal and Antiseptic Drugs on the Growth of Normal Vaginal <i>Lactobacillus</i> Strains

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Diversité étiologique des vaginites

Cited by 15 publications

References 9 publications

Prevalence of bacterial vaginosis due to Gardnerella species, vaginal candidiasis and trichomoniasis: Epidemiological aspect in women and adolescent girls in Yaoundé, Cameroon

Prevalence of bacterial vaginosis due to Gardnerella species, vaginal candidiasis and trichomoniasis: Epidemiological aspect in women and adolescent girls in Yaoundé, Cameroon

Nystatin-Neomycin-Polymyxin B Combination: Efficacy and Tolerance as 1st-Line Local Treatment of Infectious Vaginitis

Topical Treatment of Infectious Vaginitis: Effects of Antibiotic, Antifungal and Antiseptic Drugs on the Growth of Normal Vaginal &lt;i&gt;Lactobacillus&lt;/i&gt; Strains

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Topical Treatment of Infectious Vaginitis: Effects of Antibiotic, Antifungal and Antiseptic Drugs on the Growth of Normal Vaginal <i>Lactobacillus</i> Strains