dl-trans-3,4-Dihydroxy-1-selenolane (DHSred) heals indomethacin-mediated gastric ulcer in mice by modulating arginine metabolism

Chakraborty, Saikat; Yadav, Sudhir Kumar; Subramanian, M. S.; Iwaoka, Michio; Chattopadhyay, Subrata

doi:10.1016/j.bbagen.2014.09.004

Cited by 12 publications

(3 citation statements)

References 40 publications

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“…This interaction occurs under high shear stresses within venules and depends on multiple families of adhesion molecules including ICAM-1, VCAM-1, P-selectin and E-selectin. 37 Adhesion molecules facilitated the transendothelial migration of neutrophils into the site of gastric tissue injury. In this study, levels of adhesion molecules were considerably elevated in indomethacininduced ulcerated animals.…”

Section: Discussionmentioning

confidence: 99%

Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms

et al. 2016

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The present study was undertaken to explore gastroprotective effects of trigonelline (TRG) and to determine the potential mechanisms involved in this action. In order to evaluate the gastroprotective efficiency of TRG, an indomethacin-induced ulcer model has been applied. Antioxidants, cytokines, adhesion markers and apoptosis levels have been analyzed for the biochemical mechanism involved in TRG activity. TRG (45 mg kg(-1)) pretreated rats significantly inhibited gastric lesions by 81.71%. Indomethacin administration raises the levels of leukotriene B4 (LTB4), lipid peroxidation and myeloperoxidase (MPO) with the significant declines of prostaglandin E2 (PGE2), superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-px) levels. Conversely, TRG (45 mg kg(-1)) pretreated animals showed significant rises in PGE2 and antioxidant levels along with substantial reductions in LTB4, lipid peroxidation and MPO levels. Indomethacin-induced rats also exhibited considerable increases of pro-inflammatory cytokines including interleukin-6 (IL-6), interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α), and interferon-γ (IFN-γ) levels and decreases of anti-inflammatory cytokines such as interleukin-10 (IL-10) and interleukin-4 (IL-4), but these imbalances were normalized through treatment of TRG. The protective activity of TRG against indomethacin-induced gastric ulcer has been ascribed to three important mechanisms: (1) anti-inflammatory; (2) antioxidant; (3) anti-apoptotic pathways.

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Section: Discussionmentioning

confidence: 99%

Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms

et al. 2016

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“…Although they are not representative of the exact mechanism of all gastric ulcers, various gastric ulcer animal models are known, including ceramide-induced ulcer, indomethacin induced ulcer, Hcl-induced ulcer, cysteamine induced ulcer and ethanol induced ulcer 13, 14, 15. Among these, the ethanol (EtOH)-induced ulcer model is most preferential used animal model because it enables rapid induction and can be widely employed to test the efficacy of potential drugs independent of gastric acid secretion.…”

Section: Introductionmentioning

confidence: 99%

Anti-ulcer effect of Gallarhois extract with anti-oxidant activity in an ICR model of ethanol/hydrochloride acid-induced gastric injury

Song

Kim

Sung

et al. 2019

Journal of Traditional and Complementary Medicine

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Gallarhois (GR) is a traditional oriental herbal medicine with various pharmacological effects; however, its effect on gastric ulcer has not been previously explored. We firstly investigated the component and antioxidant activity of GR extract (EtGR) by HPLC analysis and 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay. The results showed that EtGR consisted of gallotannin (68.7%), gallic acid (27.2%) and methyl gallate (4.1%) and that it had a high antioxidant value (IC50 value; 1.93 μg/mL). To evaluate the possible anti-gastric ulcer potential of EtGR, we investigated the effects of EtGR in the model of ethanol/hydrochloric acid (EtOH/HCl)-induced gastric ulcer. Gross and histological gastric lesions, biochemical and gene expression parameters were taken into consideration. The results showed that EtOH/HCl treatment produced mucosal injuries with morphological and histological damage, whereas EtGR co-treatment reduced the gastric injuries. EtGR treatment also decreased the contents of malonaldehyde (MDA) activity relative to the vehicle group. Moreover, EtGR decreased the levels of interleukin-1β (IL-1β), interleukin-6 (IL-6) and cyclo-oxygenase-2 (COX-2) expression. Finally, EtGR did not induce any specific toxicity in the livers or kidneys of the EtOH/HCl-induced gastric ulcer model. These results suggest that EtGR had stronger antioxidant activity and could be a new useful natural drug for gastroprotection against gastric ulcer. Moreover, these findings provide a scientific basis for the development of drugs from traditional oriental herbal medicines.

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“…trans-3,4-Dihydroxyselenolane (DHS) is a water-soluble five-membered ring selenide with a selenoenzyme-like unique redox catalytic activity through the reversible oxidation to the selenoxide >Se=O (DHS ox ) [23,24]. It is also a stable molecule with low toxicity [25,26]. These features are potential merits of DHS when it is applied to medicinal and material Molecules 2023, 28, 3607 2 of 10 sciences.…”

Section: Introductionmentioning

confidence: 99%

Controlling the Redox Catalytic Activity of a Cyclic Selenide Fused to 18-Crown-6 by the Conformational Transition Induced by Coordination to an Alkali Metal Ion

2023

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trans-3,4-Dihydroxyselenolane (DHS), a water-soluble cyclic selenide, exhibits selenoenzyme-like unique redox activities through reversible oxidation to the corresponding selenoxide. Previously, we demonstrated that DHS can be applied as an antioxidant against lipid peroxidation and a radioprotector by means of adequate modifications of the two hydroxy (OH) groups. Herein, we synthesized new DHS derivatives with a crown-ether ring fused to the OH groups (DHS-crown-n (n = 4 to 7), 1–4) and investigated their behaviors of complex formation with various alkali metal salts. According to the X-ray structure analysis, it was found that the two oxygen atoms of DHS change the directions from diaxial to diequatorial by complexation. The similar conformational transition was also observed in solution NMR experiments. The 1H NMR titration in CD3OD further confirmed that DHS-crown-6 (3) forms stable 1:1 complexes with KI, RbCl and CsCl, while it forms a 2:1 complex with KBPh4. The results suggested that the 1:1 complex (3·MX) exchanges the metal ion with metal-free 3 through the formation of the 2:1 complex. The redox catalytic activity of 3 was evaluated using a selenoenzyme model reaction between H2O2 and dithiothreitol. The activity was significantly reduced in the presence of KCl due to the complex formation. Thus, the redox catalytic activity of DHS could be controlled by the conformational transition induced by coordination to an alkali metal ion.

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dl-trans-3,4-Dihydroxy-1-selenolane (DHSred) heals indomethacin-mediated gastric ulcer in mice by modulating arginine metabolism

Cited by 12 publications

References 40 publications

Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms

Protective effects of trigonelline against indomethacin-induced gastric ulcer in rats and potential underlying mechanisms

Anti-ulcer effect of Gallarhois extract with anti-oxidant activity in an ICR model of ethanol/hydrochloride acid-induced gastric injury

Controlling the Redox Catalytic Activity of a Cyclic Selenide Fused to 18-Crown-6 by the Conformational Transition Induced by Coordination to an Alkali Metal Ion

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