DNA cleavage, antimicrobial, spectroscopic and fluorescence studies of Co(II), Ni(II) and Cu(II) complexes with SNO donor coumarin Schiff bases

Patil, Sangamesh A.; Naik, Vinod H.; Kulkarni, Ajaykumar D.; Badami, Prema S.

doi:10.1016/j.saa.2009.10.039

Cited by 102 publications

(33 citation statements)

References 44 publications

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“…Such chelation increases the lipophilic nature of the central metal atom, which favors its permeation more efficiently through the lipid layer of the microorganism, thus destroying them more forcefully. 23,44) …”

Section: -27)mentioning

confidence: 99%

Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Budige

Puchakayala

Kongara

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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Schiff bases have a variety of applications in biological, clinical, and pharmacological areas. The synthesis and application of Schiff bases and their coordination compounds have been highly considered in inorganic, organic and biological fields, since their structural properties similar to some of the biological systems.1-6) Additionally, tetradentate Schiff bases composed of N 2 O 2 donor atoms set have been recognized as a kind of important chelating ligands for designing medicinally and catalytically useful metal complexes. [7][8][9] The flexible coordination behavior of these types of chelating ligands could also be useful to generate interesting dimeric and polymeric structures as synthones for supramolecular chemistry. 10,11) Usually, the N, O donor heterodentate Schiff bases can be derived by condensing the aldehydes/ketones with various amines or amino acids. 12,13) N 2 O 2 Schiff base ligands derived from salicylald ehyde and diamine have been known. 14,15) Dialdehydes and diketones with amines and amino acids have also been utilized to obtain a variety of N 2 O 2 Schiff base ligands. 16)Amino acids plays an important role in many physiological activities of the human body and also helpful in understanding biological functions of macromolecules such as proteins. 17) In particular, tryptophan (Trp)/histidine (His) analogues as promising candidates for novel antimicrobial therapeutics. In the recent years, a series of synthetic peptide analogues based on Trp-His and His-Arg (antimicrobial peptides) structural frameworks have been prepared and found to be active against several Gram-positive and Gram-negative bacterial strains as well as against fungal strains.18) Furthermore, it is well known that the human body contains essential metaloelements which play important roles and interact with many biological molecules to fully understand the physiological functions by studying their chemistry coordination and behavior. 17,18) In the present studies we have introduced an azomethine (Schiff base) linkage to tryptophan/histidine, which may permit a variety in their coordination behaviour and complexation role.In previous studies, we have described the synthesis, catalytic and biological applications of Schiff bases and their metal complexes derived from o-phthalaldehyde (OPA) with various amines. [19][20][21][22][23][24][25][26][27] In this respect, we have also developed some useful macrocyclic Schiff bases and their metal complexes. Results from these studies have also shown that complexation of metals with Schiff base ligands serves to improve their antimicrobial activity. There are few other research groups also reported the importance of Schiff base chemistry of the combination of o-phthalaldehyde with amines.28,29) However, a careful literature survey reveals that Schiff bases from the combination of amino acids and o-phthalaldehyde and their coordination behavior towards the transition elements have yet not been studied. The combination of dialdehyde i.e. o-phthalaldehyde and aminoacids is expected to ...

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Section: -27)mentioning

confidence: 99%

Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Budige

Puchakayala

Kongara

et al. 2011

CHEMICAL & PHARMACEUTICAL BULLETIN

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“…The antifungal efficacy of the prepared compounds was tested against T.longifusus, C.albican, A.flavus and P.carinii fungal species using the protocol mentioned in the literature 21 . All fungi were cultured in agar medium and incubated at 36 o C for 48 hr.…”

Section: In Vitro Antifungal Activitymentioning

confidence: 99%

Biological evaluation of inhibitors of reverse transcriptase from HIV type-1

Lautre¹,

Hadda²,

Das³

et al. 2015

10.5267/j.ccl

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In the present work, Zn(II), Co(II) and Cr(II) metal complexes (3-5) of N-hydroxy-4-[(hydroxyimino)methyl]benzamidine ligand (2) were synthesized and their anti-HIV activity by inhibiting reverse transcriptase was explored. Structural characterization using NMR, FTIR, Mass, UV-Vis spectra, TGA, magnetic moment and elemental analyses were performed. The analyses show that geometry, lipophilicity and steric factor play crucial role. Cell viability test is performed on peripheral blood mononuclear cells to check toxicity of prepared compounds on immune system, shows toxicity only at higher concentration. Antimicrobial activity and DNA cleavage analysis have also been studied and reported.

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“…It is used as an intermediate in the production of pesticides, rodenticides and anticoagulants [1]. On the other hand, thiosemicarbazones are useful in the medicinal and pharmaceutical fields because of their great significant pharmacological properties such as antibacterial [2] [3] [4], antifungal [2], anti-HIV [5] [6], anticancer [7] [8], antineoplastic [9], anti-inflammatory [10], tuberclostatic [11] and their variable bonding nature. The biological activities of thiosemicarbazones often depend on the parent aldehyde or ketone.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Molecular Structure and Antibacterial Activity of Benzylmethyl-4-Methyl-3-Thiosemicarbazone

Mbah¹,

Ayimele²,

Eyonganyoh³

et al. 2017

IJOC

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A novel Schiff base, benzylmethyl-4-methyl-3-thiosemicarbazone (BMM) derived from benzylmethylketone and 4-methylthiosemicarbazide was synthesized and characterized by elemental analysis, spectroscopic methods (IR, 1 H NMR, 13 C NMR) and physical means. The single crystal structure analysis of the Schiff base reveals that it crystallizes in a monoclinic system in the P2 1 /c space group. BMM revealed moderate antibacterial activity on three bacterial strains with diameter zone of inhibition of 16 mm (E. coli), 14 mm (K. pneumonia) and 13 mm (S. epidermidis) compared with the standard drug, ciprofloxacin.

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DNA cleavage, antimicrobial, spectroscopic and fluorescence studies of Co(II), Ni(II) and Cu(II) complexes with SNO donor coumarin Schiff bases

Cited by 102 publications

References 44 publications

Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Synthesis, Characterization and Biological Evaluation of Mononuclear Co(II), Ni(II), Cu(II) and Pd(II) Complexes with New N2O2 Schiff Base Ligands

Biological evaluation of inhibitors of reverse transcriptase from HIV type-1

Synthesis, Molecular Structure and Antibacterial Activity of Benzylmethyl-4-Methyl-3-Thiosemicarbazone

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