DNA damage induced by a chromium(III) Schiff base complex is reversible under physiological condition

<b>Synthesis and DNA interaction of a Sm(III) complex of a Schiff base derived from vanillin and L-tryptophan</b>

“…DNA is the primary intracellular target of anticancer reagents because interaction between metal complexes and DNA can cause damage in cancer cells, blocking cell division [1,2]. To date, much attention has been paid to binding of metal complexes containing multidentate aromatic ligands.…”

DNA-binding and cleavage studies of chiral Mn(III) salen complexes

“…Studies on their DNA-binding/cleaving properties are of great importance for the design of sequence specific-or stereo-specific artificial nucleases. Metal complexes of salen can also bind DNA and induce DNA strand breakage in the presence of a reducing/oxidizing agent [6][7][8]. Gravert and Griffin [9] synthesized some cationic manganese(III)-salen derivatives and studied the interaction between these complexes and DNA.…”

Synthesis, characterization and catalytic activity of neat and alumina supported trans-(diaqua)(N,N-ethylene-bis-salicylamide)chromium(III): a comparative study

“…Transition metal complexes having quadridentate Schiff base ligands like Salen {N,N 0 -bis(salicylidene)ethane-1,2-diamine} and its prototype have continued to be an active area of research because of their potential applications in catalytic [1][2][3][4][5][6][7][8][9][10] and biological [11][12][13] processes. Schiff bases with different substituents in the ligand peripheries lead to substantially different solid-state structures and reactivities.…”