DNA Repair Gene<i>XRCC3</i>T241M Polymorphism and Bladder Cancer Risk in a Chinese Population

Zhu, Xuan; Zhong, Zhaohui; Zhang, Xuanzhi; Zhao, Xiaokun; Xu, Ran; Ren, Weigang; Li, Songchao

doi:10.1089/gtmb.2011.0334

Cited by 19 publications

(10 citation statements)

References 19 publications

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“…Others studies found no correlation between the XRCC3 genotypes and clinical stage (Krupa et al, 2011;Zhu et al, 2012). According to Krupa et al (2011), different findings for XRCC3 Thr241Met could be related to complex interactions between this polymorphism and others, underlined by mechanisms not yet described.…”

Section: Discussionmentioning

confidence: 92%

Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study

Pereira

Fontes

Medeiros

et al. 2016

Archives of Oral Biology

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A B S T R A C TObjective: to evaluate the association between XPD and XRCC3 polymorphisms and oral squamous cell carcinoma (OSCC). Design: the sample consisted of 54 cases of OSCC and 40 cases of inflammatory fibrous hyperplasia (IFH). Genotypes were determined by the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method. Results: XPD-Lys/Gln was more common in IFH (n = 28; 70%) than in OSCC (n = 24; 44.4%) (OR: 0.3; p < 0.05). XPD-Gln was more frequent in high-grade lesions (0.48) than in low-grade lesions (0.21) (OR: 3.4; p < 0.05). The Gln/Gln genotype was associated with III and IV clinical stages (OR: 0.07; p < 0.05). XRCC3-Met was more frequent in OSCC (0.49) than in IFH (0.35) (OR: 2.6; p < 0.05). The Met/Met genotype was associated with the presence of metastases (OR: 8.1; p < 0.05) and with III and IV clinical stages (OR: 0.07; p < 0.05). Conclusions: in this sample, the frequency of XPD-Gln in IFH suggests that this variant may protect against OSCC. The presence of the XRCC3-Met allele seems to contribute to the development of OSCC, metastases and more advanced stages in these lesions.

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Section: Discussionmentioning

confidence: 92%

Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study

Pereira

Fontes

Medeiros

et al. 2016

Archives of Oral Biology

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“…Table 1 showed the characteristics of all the eligible studies and genotype frequency distributions of twelve polymorphisms in five XRCC genes ( XRCC1 -rs915927, XRCC1 -rs25489, XRCC1 -rs25487, XRCC1 -rs1799782, XRCC1 -rs3213245, XRCC2 -rs3218536, XRCC3 -rs1799796, XRCC3 -rs861539, XRCC4 -rs6869366, XRCC4 -rs28360071, XRCC4 -rs1805377, XRCC7 -rs7003908) included in current meta-analysis (Agalliu et al, 2010, Andrew et al, 2015, Andrew et al, 2007, Andrew et al, 2006, Arizono et al, 2008, Berhane et al, 2012, Broberg et al, 2005, Chang et al, 2009, Lan et al, 2006, Lavender et al, 2010, Chang et al, 2008, Dhillon et al, 2009, Figueroa et al, 2007a, Figueroa et al, 2007b, Fontana et al, 2008, Gangwar et al, 2009, Hamano et al, 2008, Hirata et al, 2006, Hirata et al, 2007, Huang et al, 2007, Abe et al, 2011, Mittal et al, 2008, Narter et al, 2009, Nowacka-Zawisza et al, 2015, Ramaniuk et al, 2014, Ritchey et al, 2005, Rybicki et al, 2004, Sak et al, 2007, Sanyal et al, 2004, Shen et al, 2003, Stern et al, 2002, Stern et al, 2001, Van Gils et al, 2002, Wang et al, 2010, Wang et al, 2008, Wen et al, 2009, Wen et al, 2013, Wu et al, 2006, Xu et al, 2007, Zhi et al, 2012, Hao et al, 2008, Zhou et al, 2012, Zhu et al, 2014, Zhu et al, 2012, Kelsey et al, 2004, Kuasne et al, 2011, Luedeke et al, 2009, Mandal et al, 2010, Mandal et al, 2011, Matullo, 2005, Matullo et al, 2006, Matullo et al, 2001, Mittal et al, 2012a, Mittal et al, 2012b). The study selection processes were presented in Supplementary Figs.…”

Section: Resultsmentioning

confidence: 99%

“…In the study performed by Shen et al (2003), they found that the XRCC3 rs861539 variant genotype exhibited a protective effect against BC (OR = 0.63; 95% CI = 0.42–0.93), which was further validated by Narter et al (2009). On the contrary, Zhu et al (2012) genotyped a comprehensive case-control studies of 150 BC cases and 150 controls and identified an elevated BC risk among individuals who carry at least one mutated variant allele (OR = 3.22, 95% CI = 1.14–9.11, P = 0.030), and similar results was also obtained by Andrew et al (2007) Moreover, the frequency of XRCC 3-rs861539 genotype distributions in some of the control groups were departed from HWE and thus we cannot rule out the possibility that such an association occurred as a result of bias. Then, we conducted a subgroup analysis by HWE status, and identified that HWE status did not give rise to the bias of results.…”

Section: Discussionmentioning

confidence: 97%

Association Between Twelve Polymorphisms in Five X-ray Repair Cross-complementing Genes and the Risk of Urological Neoplasms: A Systematic Review and Meta-Analysis

Zhang¹,

Li²,

Hao³

et al. 2017

EBioMedicine

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Polymorphisms in X-ray repair cross-complementing (XRCC) genes have been implicated in altering the risk of various urological cancers. However, the results of reported studies are controversial. To ascertain whether polymorphisms in XRCC genes are associated with the risk of urological neoplasms, we conducted present updated meta-analysis and systematic review. Summary odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were used to estimate the association. Finally, 54 publications comprising 129 case-control studies for twelve polymorphisms in five XRCC genes were enrolled. We identified that XRCC1-rs25489 polymorphism was associated with an increased risk of urological neoplasms in heterozygote and dominant models. Moreover, in the subgroup analysis by cancer type, we found that XRCC1-rs25489 polymorphism was associated with an increased risk of bladder cancer (BC) in heterozygote model. Although overall analyses suggested a null result for XRCC1-rs25487 polymorphism, in the stratified analysis by ethnicity, an increased risk of urological neoplasms for Asians in allelic and homozygote models was identified. While for other polymorphisms in XRCC genes, no significant association was uncovered. To sum up, our results indicated that XRCC1-rs25489 polymorphism is a risk factor for urological neoplasms, particularly for BC. Further studies with large sample size are needed to validate these findings.

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“…As the most common functional SNP, the XRCC3 Thr241Met (rs861539) polymorphism is at codon 241 in exon 7 with a C to T transition (12). The XRCC3 Thr241Met polymorphism has been investigated in various types of cancer and the results are mixed (13–17). …”

Section: Introductionmentioning

confidence: 99%

DNA repair gene XRCC3 Thr241Met polymorphism and susceptibility to glioma: A case-control study

Wang

Xie

et al. 2014

Oncology Letters

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The DNA repair gene, X-ray repair cross-complementing group 3 (XRCC3) Thr241Met polymorphism may be associated with a susceptibility to glioma. The present study aimed to investigate the association between the XRCC3 Thr241Met polymorphism and the potential susceptibility to gliomas. A hospital-based case-control study was conducted, which included a total of 886 patients with glioma and 886 healthy control subjects. Peripheral blood samples were extracted and the polymerase chain reaction-restriction fragment length polymorphism method was performed to analyze the genotypes. The glioma patients had a significantly higher frequency of the XRCC3 241 MetMet genotype [odds ratio (OR) = 1.62; 95% confidence interval (CI): 1.09–2.41; P=0.02] compared with the control subjects. When stratified by the grade of the glioma, the patients with stage IV glioma (according to the World Health Organization classification) had a significantly higher frequency of the XRCC3 241 MetMet genotype (OR=1.61; 95% CI: 1.06–2.44; P=0.03). When stratified by the histology of the glioma, there was no significant difference in the distribution of each genotype. The findings of the present study indicate that the XRCC3 Thr241Met polymorphism is associated with a susceptibility to glioma.

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DNA Repair GeneXRCC3T241M Polymorphism and Bladder Cancer Risk in a Chinese Population

Cited by 19 publications

References 19 publications

Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study

Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study

Association Between Twelve Polymorphisms in Five X-ray Repair Cross-complementing Genes and the Risk of Urological Neoplasms: A Systematic Review and Meta-Analysis

DNA repair gene XRCC3 Thr241Met polymorphism and susceptibility to glioma: A case-control study

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