DNA sequence analysis and polymorphism of the mouse CD4 gene

A 7-bp deletion in the Cd4 gene, present in the strain MOLF/Ei of Mus musculus molossinus and absent in laboratory mouse strains ( Mus musculus musculus), provided the means to distinguish the parental origin of the Cd4 alleles expressed in single cells of F1 (AKR x MOLF/Ei) and F1 (Balb/C x MOLF/Ei) hybrids. Single-cell RT-PCR showed that the individual CD4+ lymphocyte expresses either the maternal or the paternal Cd4 allele, never both. In situ hybridization proved that Cd4 alleles replicate asynchronously, as expected in the case of genes expressed monoallelically.

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Monoallelic expression of mouse Cd4 gene

Capparelli

Costabile

Viscardi

et al. 2004

Mamm Genome

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DNA sequence analysis and polymorphism of the mouse CD4 gene

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Monoallelic expression of mouse Cd4 gene

Monoallelic expression of mouse Cd4 gene

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