DNA topoisomerases in the unicellular protozoan parasites: Unwinding the mystery

Novel 2-substituted-quinoxaline analogs with potential antiproliferative activity against breast cancer: insights into cell cycle arrest, topoisomerase II, and EGFR activity

“…Based on their ability to unwind both DNA strands at once, topoisomerases are categorized into two groups, topoisomerase I and topoisomerase II. 20 Topoisomerases I and II (Top 1 and Top 2 as they are more often known) are largely considered to be significant molecular targets for the development of anticancer medicines. 21 Irinotecan, topotecan, and camptothecin are well-known examples of topoisomerase I (Topo I) inhibitors.…”