Do distinct atypical cortical networks process biological motion information in adults with Autism Spectrum Disorders?

McKay, Lawrie S.; Simmons, David R.; McAleer, Phil; Marjoram, Dominic; Piggot, Judith; Pollick, Frank E.

doi:10.1016/j.neuroimage.2011.08.033

Cited by 68 publications

(72 citation statements)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This right hemisphere region was also identified by a recent meta-analysis to have the greatest probability of being found in experiments on body movements . In the left hemisphere this region (−45, −64, 1) has been reported to be a primary node in the processing of biological motion, demonstrating functional connectivity with occipital and parietal regions (McKay et al, 2012). This right hemisphere activation is also quite similar to coordinates (48, −70, 0) previously reported for localization of the EBA .…”

Section: Discussionsupporting

confidence: 84%

Event Segmentation and Biological Motion Perception in Watching Dance

et al. 2014

Self Cite

View full text Add to dashboard Cite

We used a combination of behavioral, computational vision and fMRI methods to examine human brain activity while viewing a 386 s video of a solo Bharatanatyam dance. A computational analysis provided us with a Motion Index (MI) quantifying the silhouette motion of the dancer throughout the dance. A behavioral analysis using 30 naïve observers provided us with the time points where observers were most likely to report event boundaries where one movement segment ended and another began. These behavioral and computational data were used to interpret the brain activity of a different set of 11 naïve observers who viewed the dance video while brain activity was measured using fMRI. Results showed that the Motion Index related to brain activity in a single cluster in the right Inferior Temporal Gyrus (ITG) in the vicinity of the Extrastriate Body Area (EBA). Perception of event boundaries in the video was related to the BA44 region of right Inferior Frontal Gyrus as well as extensive clusters of bilateral activity in the Inferior Occipital Gyrus which extended in the right hemisphere towards the posterior Superior Temporal Sulcus (pSTS).

show abstract

Section: Discussionsupporting

confidence: 84%

Event Segmentation and Biological Motion Perception in Watching Dance

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

“…Indeed, hMTϩ and EBA also closely overlap with object-form-selective lateral occipital complex (Kourtzi et al, 2002;Denys et al, 2004;Downing et al, 2007;Kolster et al, 2010). Further research is needed to understand the functional interactions between these regions, for example during the processing of motion-defined shapes Farivar et al, 2009), the integration of form and motion signals, or the extraction of 3D shape from disparity and motion cues (Orban, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Eating disorders have been associated with abnormalities in EBA (Suchan et al, 2010), whereas autism spectrum disorders have been linked to pSTS abnormalities (Kaiser and Shiffrar, 2009) or dysfunctional interconnectivity between pSTS and EBA (McKay et al, 2012). The current results shed new light on these findings, suggesting differential importance of motion and form perception impairments in different clinical disorders.…”

Section: Discussionmentioning

confidence: 99%

Distinct Neural Mechanisms for Body Form and Body Motion Discriminations

et al. 2014

View full text Add to dashboard Cite

Actions can be understood based on form cues (e.g., static body posture) as well as motion cues (e.g., gait patterns). A fundamental debate centers on the question of whether the functional and neural mechanisms processing these two types of cues are dissociable. Here, using fMRI, psychophysics, and transcranial magnetic stimulation (TMS), all within the same human participants, we show that mechanisms underlying body form and body motion processing are functionally and neurally distinct. Multivoxel fMRI activity patterns in the extrastriate body area (EBA), but not in the posterior superior temporal sulcus (pSTS), carried cue invariant information about the body form of an acting human. Conversely, multivoxel patterns in pSTS, but not in EBA, carried information about the body motion of the same actor. In a psychophysical experiment, we selectively impaired body form and body motion discriminations by manipulating different visual cues: misaligning the ellipses that made up a dynamic walker stimulus selectively disrupted body form discriminations, while varying the presentation duration of the walker selectively affected body motion discriminations. Finally, a TMS experiment revealed causal evidence for a double-dissociation between neural mechanisms underlying body form and body motion discriminations: TMS over EBA selectively disrupted body form discrimination, whereas TMS over pSTS selectively disrupted body motion discrimination. Together, these findings reveal complementing but dissociable functions of EBA and pSTS during action perception. They provide constraints for theoretical and computational models of action perception by showing that action perception involves at least two parallel pathways that separately contribute to the understanding of others' behavior.

show abstract

“…There is some fMRI evidence of altered motion processing in ASD; for example whilst biological motion recognition typically uses a unitary parietal-temporal axis, whilst ASD individuals utilised a different network comprising form and motion centres rather than the unitary network used by the TD group [48]. In a separate study, Koldewyn et al (2011) found reduced activity to biological motion in the posterior superior temporal sulcus, parietal and frontal lobe activity [49].…”

Section: Discussionmentioning

confidence: 99%

Motion and pattern cortical potentials in adults with high-functioning autism spectrum disorder

et al. 2012

View full text Add to dashboard Cite

This is the accepted version of the paper.This version of the publication may differ from the final published version. Autism Spectrum Disorder (ASD) is a condition in which visual perception to both static and moving stimuli is altered. The aim of this study was to investigate the early cortical responses of subjects with ASD to simple patterns and moving radial rings using visual evoked potentials (VEP). Permanent repository link MethodsMale ASD participants (n=9) and typically developing (TD) individuals (n=7) were matched for full, performance and verbal IQ (p>0.263). VEPs were recorded to the pattern reversing checks of 50'sidelength presented with Michelson contrasts of 98% and 10% and to the onset of motion -either expansion or contraction of low contrast concentric rings, (33.3% duty cycle at 10% contrast). ResultsThere were no significant differences between groups in the VEPs elicited by pattern reversal checkerboards of high (98%) or low (10%) contrast. The ASD group had a significantly larger N160 peak (1.85 x) amplitude to motion onset VEPs elicited by the expansion of radial rings (p=0.001). No differences were evident in contraction VEP peak amplitudes nor in the latencies of the motion onset N160 peaks. There was no evidence of a response that could be associated with adaptation to the motion stimulus in the inter-stimulus interval following an expansion or contraction phase of the rings. ConclusionThese data support a difference in processing of motion onset stimuli in this adult, high functioning ASD group compared to the TD group. 3Key Words:Autism Spectrum Disorder, Motion onset, Pattern reversal, VEPs, ContrastIntroduction:

show abstract

Do distinct atypical cortical networks process biological motion information in adults with Autism Spectrum Disorders?

Cited by 68 publications

References 76 publications

Event Segmentation and Biological Motion Perception in Watching Dance

Event Segmentation and Biological Motion Perception in Watching Dance

Distinct Neural Mechanisms for Body Form and Body Motion Discriminations

Motion and pattern cortical potentials in adults with high-functioning autism spectrum disorder

Contact Info

Product

Resources

About