Do Inhaled Carbon Nanoparticles Translocate Directly into the Circulation in Humans?

Mills, Nicholas L; Amin, Nadia; Robinson, Simon D.; Anand, Atul; Davies, John; Patel, Dilip; Fuente, Jesús M. de la; Cassee, Flemming R.; Boon, Nicholas A.; MacNee, William; Millar, A. M.; Donaldson, Ken; Newby, David E.

doi:10.1164/rccm.200506-865oc

Cited by 288 publications

(166 citation statements)

References 19 publications

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“…We showed how information obtained from imaging could be coupled with blood concentration measurements to update kinetics parameters distribution in a Bayesian framework. We obtained similar results relative to free technetium kinetics than other studies (ICRP, 1999;Mills et al, 2005;Wiebert et al, 2006), a high elimination rate through urine, and less than 5% of swallowed particles. The estimated fraction of unbound technetium (6.7%) was also very coherent with the one found by Mills et al (2005) at approximately 5%.…”

Section: Discussionsupporting

confidence: 86%

Development of a physiologically based kinetic model for 99m-Technetium-labelled carbon nanoparticles inhaled by humans

Péry

Brochot

Hoet

et al. 2009

Inhalation Toxicology

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To cite this version:Alexandre Pery, Céline Brochot, Peter Hoet, Abderrahim Nemmar, Frédéric Y. Bois. Development of a physiologically based kinetic model for 99m-Technetium-labelled carbon nanoparticles inhaled by humans. Inhalation Toxicology, Taylor & Francis, 2009, 21 (13) analysis points to a likely translocation of particle-bound technetium from lung to blood, at a rate about 2-fold lower than the transfer rate of free technetium. Notably, restricting the model so that only free technetium would have been able to reach blood circulation result in much poorer fits to the experimental data. The percentage of small particles able to translocate was estimated at 12.7% of total particles. The percentage of unbound technetium was estimated at 6.7% of total technetium. To our knowledge, our model is the first PBPK model able to use imaging data to describe the absorption and distribution of nanoparticles. We believe that our modeling approach using Bayesian and MCMC techniques provides a reasonable description on which to base further model refinement.2

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Section: Discussionsupporting

confidence: 86%

Development of a physiologically based kinetic model for 99m-Technetium-labelled carbon nanoparticles inhaled by humans

Péry

Brochot

Hoet

et al. 2009

Inhalation Toxicology

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“…Systemic translocation of particles was demonstrated in experimental animal models (Nemmar et al 2001) (Oberdorster et al 2002). Although evidence of systemic translocation from human studies is less clear, with both positive (Nemmar et al 2002, Pery et al 2009) and negative (Mills et al 2006) findings, it is likely that this pathway also exists in humans, given the deep penetration of UFP into the alveoli and the close apposition of the alveolar wall and the capillary network. Radioactivity in the systemic circulation was already detected 1 minute after the inhalation of radioactively labelled carbon particles in humans, with peak radioactivity levels between 10 and 20 minutes (Nemmar et al 2002).…”

Section: Particle Triggered Pathophysiological Mechanismsmentioning

confidence: 99%

Air Pollution and Cardiovascular Disease

Emmerechts¹,

Jacobs²,

Hoylaerts³

2011

The Impact of Air Pollution on Health, Economy, Environment and Agricultural Sources

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“…Catalytic metal can distribute throughout the body (Huang et al ., 2010). In a study of the biodistribution of 99m Tc‐radiolabeled carbon nanoparticles, 99m Tc or its oxides could enter the blood circulation independently of the nanoparticle (Mills et al ., 2006). Deng et al .…”

Section: Discussionmentioning

confidence: 99%

Long‐term retention of pristine multi‐walled carbon nanotubes in rat lungs after intratracheal instillation

Shinohara

Nakazato

Ohkawa

et al. 2015

J of Applied Toxicology

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As a result of the growing potential industrial and medical applications of multi‐walled carbon nanotubes (MWCNTs), people working in or residing near facilities that manufacture them may be exposed to airborne MWCNTs in the future. Because of concerns regarding their toxicity, quantitative data on the long‐term clearance of pristine MWCNTs from the lungs are required. We administered pristine MWCNTs well dispersed in 0.5 mg ml−1 Triton‐X solution to rats at doses of 0.20 or 0.55 mg via intratracheal instillation and investigated clearance over a 12‐month observation period. The pristine MWCNTs pulmonary burden was determined 1, 3, 7, 28, 91, 175 and 364 days after instillation using a method involving combustive oxidation and infrared analysis, combined with acid digestion and heat pretreatment. As 0.15‐ and 0.38‐mg MWCNTs were detected 1 day after administration of 0.20 and 0.55 mg MWCNTs, respectively, approximately 30% of administrated MWCNTs may have been cleared by bronchial ciliary motion within 24 h of administration. After that, the pulmonary MWCNT burden did not decrease significantly over time for up to 364 days after instillation, suggesting that MWCNTs were not readily cleared from the lung. Transmission electron microscopy (TEM) showed that alveolar macrophages internalized the MWCNTs and retained in the lung for at least 364 days after instillation. MWCNTs were not detected in the liver or brain within the 364‐day study period (<0.04 mg per liver, < 0.006 mg per brain). Copyright © 2015 The Authors Journal of Applied Toxicology Published by John Wiley & Sons Ltd.

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Do Inhaled Carbon Nanoparticles Translocate Directly into the Circulation in Humans?

Cited by 288 publications

References 19 publications

Development of a physiologically based kinetic model for 99m-Technetium-labelled carbon nanoparticles inhaled by humans

Development of a physiologically based kinetic model for 99m-Technetium-labelled carbon nanoparticles inhaled by humans

Air Pollution and Cardiovascular Disease

Long‐term retention of pristine multi‐walled carbon nanotubes in rat lungs after intratracheal instillation

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