Do Tumor Cavitation and Sex in Resected Stage I Non‐Small‐Cell Lung Cancer Correlate with Prognosis?

Wang, Meng; Zhao, Jing; Pan, Yi; Su, Yan; You, Jian; Zhao, Xiaomeng; Wang, Chang Li

doi:10.1007/s00268-008-9859-3

Cited by 11 publications

(5 citation statements)

References 45 publications

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“…Hsu et al 78) reported that median survival was the same for never-smoking women and never-smoking men with adenocarcinoma, suggesting that both smoking status and histologic type rather than gender decided survival. In several studies, 34,40,70) a significant survival advantage for women disappeared after statistically adjusting for smoking status, although in other studies 28,41,49,51,53,57,58,76,77) survival advantages for women persisted after adjustment for smoking. In our meta-analysis, which combined these conflicting studies, female gender still persisted as a favorable prognostic factor, independent of smoking status.…”

Section: Figmentioning

confidence: 96%

Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Nakamura

Ando

Shinmyo

et al. 2011

Ann Thorac Cardiovasc Surg

120

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Purpose: It is not clear whether women with non-small-cell lung cancer (NSCLC) live significantly longer than men. Thus, we conducted a meta-analysis of published studies to quantitatively compare NSCLC survival data between genders. Materials and Methods: A MEDLINE Web search for computer-archived bibliographic data regarding overall survival differences between genders was performed. DerSimonian-Laird random effects analysis was used to estimate the pooled hazard ratio (HR). Results: We selected 39 articles as appropriate data sources, involving 86 800 patients including 32 701 women and 54 099 men. Combined HRs for women vs. men in studies using univariate and multivariate analyses respectively were 0.79 (p <0.0001) and 0.78 (p <0.0001). Pooled HRs for 3 study subgroups having (1) fewer than 30% stage I cases, (2) fewer than 50% adenocarcinoma cases, and (3) statistical adjustment for smoking status all indicated the survival advantage of women. Conclusion: This meta-analysis of published data concerning NSCLC patients indicated significantly better survival for women.

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Section: Figmentioning

confidence: 96%

Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Nakamura

Ando

Shinmyo

et al. 2011

Ann Thorac Cardiovasc Surg

120

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“…The mechanism of cystic airspace formation in lung cancer is not fully understood. Some researchers believe that cystic airspace is correlated with rapid tumor growth that oversteps the blood supply of the tumor, thus creating necrosis in the middle of the tumor ( 22 ). Clinically, cystic airspace has been reported to be an independent factor for poor prognosis in patients with resected early-staged lung cancer ( 23 ).…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and progression of pre-/minimally invasive lung adenocarcinoma harboring ALK or RET rearrangements: a retrospective cohort study

Deng,

Chen,

Bai

et al. 2023

Transl Lung Cancer Res

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Background Patients harboring anaplastic lymphoma kinase ( ALK ) or rearranged during transfection ( RET ) rearrangements are usually diagnosed at a relatively late stage with nodal and distant metastasis, and rapid progression course of ALK / RET fusion-positive lung cancer were well-known. However, clinical characteristics and course of pre-/minimally invasive lung adenocarcinoma harboring ALK or RET fusions are poorly described. Identifying patients with gene fusions at early stage may offer surgical options that could cure those patients. Methods We retrospectively included patients with surgically resected pre-/minimally invasive lung adenocarcinomas harboring epidermal growth factor receptor ( EGFR ) mutations or ALK / RET rearrangements, and further compared the patient clinical characteristics, nodule natural course, and survival outcomes. Radiological characteristics including ground-glass component, cystic airspace, pleural attachment, etc. were specially assessed for this study. EGFR (exons 18–22) was detected by Sanger sequencing and quantitative real-time polymerase chain reaction (qRT-PCR) was used to analyze the ALK / RET rearrangements. Lung cancer-specific survival (LCSS), relapse-free survival (RFS), and overall survival (OS) were all evaluated. Results Of 238 patients with pre-/minimally invasive lung adenocarcinomas, 226 patients had EGFR mutations, 7 patients had ALK fusions, and 5 patients had RET fusions. Average age at surgery was 45.3 years for ALK / RET -positive group and 52.6 years for EGFR -positive group (P=0.049). Radiologically, among the 12 patients with ALK / RET fusions, the majority of lesions (10/12) manifested as mixed ground-glass opacities (mGGOs), which was significantly more prevalent when compared with patients with EGFR mutations (83.4% vs. 24.3%, P<0.001). Moreover, a substantial proportion of cystic airspace was found in ALK / RET -positive group but not in EGFR -positive group (66.7% vs. 14.2%, P<0.001). Among four patients with ALK / RET fusions undergoing surveillance over 1 year before surgery, two of them developed rapid radiologic progression. The 5-year LCSS and RFS were 100%, 100% for ALK / RET ...

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“…[ 10 ] The literature about the prognosis of cavitary NSCLC (NSCLC-c) compared with noncavitary NSCLC (NSCLC-nc) is limited to a few reports. The presence of the cavity in primary lung cancer has been associated with a worse prognosis in some reports based on radiographic exams and CT.[ 11 12 13 ] In other reports, however, there was no difference between cavitary lung cancer and noncavitary lung cancer. [ 14 15 ]…”

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confidence: 94%

Are there radiographic, metabolic, and prognostic differences between cavitary and noncavitary nonsmall cell lung carcinoma? A retrospective fluorodeoxyglucose positron emission tomography/computed tomography study

et al. 2016

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AIMS:The prognosis of nonsmall cell lung cancer with cavitation (NSCLC-c) is not well-known. We compared the positron emission tomography/computed tomography (PET/CT) findings and survival data of patients with NSCLC-c patients with those without cavitation (NSCLC-nc).METHODS:Between 7/2004 and 6/2007, cavitary lung lesions were identified in 46/248 patients undergoing fluorodeoxyglucose (FDG) PET/CT for lung nodule characterization or lung cancer staging. Within the same period, 40 of 202 patients with NSCLC-nc were randomly selected for comparison. The primary was assessed by location, size, cell type, and standardized uptake value (SUV). Disease stage was determined according to American Joint Committee on Cancer guidelines for lung cancer. Kaplan–Meier method was used for survival analysis and Cox regression to assess the effect of clinical and imaging variables on survival.RESULTS:NSCLC-c was found in 87% of patients that had a cavitary lung lesion at PET/CT. Squamous cell carcinoma, primary size and primary-to-liver SUV ratio differed significantly between NSCLC-c and NSCLC-nc, whereas age, gender, primary location, primary SUV, type of treatment, and disease stage did not. Median survival and overall 5-year survival were 19 months and 24% for NSCLC-c, and 31 months and 31% for NSCLC-nc, P = 0.23. Disease stage was the only predictor of survival.CONCLUSION:Cavitary lung lesions in patients undergoing FDG PET/CT harbor a significant risk for cancer. NSCLC-c is associated with squamous cell carcinoma, larger size, and greater FDG metabolism compared with NSCLC-nc, although these variables may not be predictive of survival. Nonetheless, PET/CT contributes to accurate staging and has an indirect impact on prognosis.

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Do Tumor Cavitation and Sex in Resected Stage I Non‐Small‐Cell Lung Cancer Correlate with Prognosis?

Abstract: Tumor cavitation, pathologic stage IB, and being male are predictors of poor outcome for patients with stage I NSCLC who undergo resection.

Cited by 11 publications

References 45 publications

Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Female Gender Is an Independent Prognostic Factor in Non-small-cell Lung Cancer: A Meta-analysis

Clinical characteristics and progression of pre-/minimally invasive lung adenocarcinoma harboring ALK or RET rearrangements: a retrospective cohort study

Are there radiographic, metabolic, and prognostic differences between cavitary and noncavitary nonsmall cell lung carcinoma? A retrospective fluorodeoxyglucose positron emission tomography/computed tomography study

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