Docking studies of Vitamin C, Vitamin E, Damnacanthal and Scopoletin with human lens gamma D-crystalline

Abstract

Vitamin C, Vitamin E, scopoletin and damnacanthal are the major constituents of Noni (Morinda citrifolia). These compounds are known to have good medicinal properties and they are known to act as antioxidants. Loss of vision in elderly is due to opaqueness of the lens proteins such as gamma-D-crystallin during oxidative stress conditions. Therefore, it is of importance to find the potential interaction of Vitamin C, Vitamin E, Scopoletin and Damnacanthal with the lens protein gamma-D-crystallin. Hence, their physical binding to gamma-D crystallin (PDB ID: 2G98) was evaluated using molecular and structural docking procedures. Results show the potential binding of all the above anti-oxidants to gamma-D-crystalline with equal affinity. Thus, the role of cumulative anti-oxidant effect in Noni fruit juice through their potential yet predicted interaction with the lens protein gamma-D-crystallin is implied for cataract treatment.

Photosynthetic pigments and biomass in noni irrigated with saline waters with and without leaching

“…This crop proved to adjust osmotically when subjected to the saline stress of the irrigation water and, based on this information, can be an alternative for areas affected by salinity in semiarid regions (Nivas et al, 2011;Souto et al, 2013). This crop originated in Asia and has been used in alternative medicine in many countries worldwide (Wang et al, 2002;Singh, 2012;Rentala et al, 2013).…”