Does cardiovascular risk vary according to the criteria for a diagnosis of polycystic ovary syndrome?

Ramoglu, Sedef; Yoldemir, Tevfik; Atasayan, Kemal; Yavuz, Dilek Gogas

doi:10.1111/jog.13455

Cited by 15 publications

(4 citation statements)

References 35 publications

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“…The main finding of this study is the correlation of CCA-AUC with IR among PCOS women. IR is a key player in PCOS patients, and it promotes premature atherosclerosis in more than one way [25]. Insulin resistance increases lipolysis and promotes serum dyslipidemia; the latter has an apoptosis effect on pancreatic islets.…”

Section: Discussionmentioning

confidence: 99%

“…We enrolled an unmarried female aged (18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35) suspected to be PCOS based on Rotterdam diagnostic criteria [17]; where 2 out of 3 were considered for the diagnosis; history of oligomenorrhea or amenorrhea, hyperandrogenism, whether clinical or biochemical, and signs of Polycystic ovaries in the ultrasound (US) scans [2], we restricted our inclusion to women with a body mass index (BMI) ranging from 18-30 kg/m 2. Regarding oligomenorrhea, it was defined as a history of fewer than six cycles per year. As for amenorrhea, it was defined as when the cycle was absent for more than one year [14].…”

Section: Inclusion Criteria and Exclusion Criteriamentioning

confidence: 99%

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Area Under the Curve of carotid artery Doppler as a sensitive marker of insulin sensitivity among Iraqi women with polycystic ovarian syndrome: a cross sectional study

Akram¹,

Nori²,

Zghair³

2023

It Journ Gyn Obs

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Objective. Polycystic ovarian syndrome (PCOS), a common endocrinopathy of reproductive-aged women, harbors increased insulin resistance (IR) and cardiovascular risk. Screening for associated health risks reduces morbidity and mortality. Measurement of intima-media thickness (IMT) by carotid artery Doppler (CCA) was tested as a marker for IR previously; herein, we aimed to verify the value of area under the curve (AUC) of CCA Doppler wave as a possible marker for IR in PCOS.Patients and Methods. 140 PCOS women were recruited from the ultrasound department of Al-Yarmouk Hospital; from CCA-Doppler, we recorded CCA-IMT, pulsatility index (PI), and resistance index (RI). By Graph software, AUC-CCA was calculated for all. Patients' biochemical (lipid and glucose) and hormonal parameters (FSH, LH, insulin, and testosterone) were checked. Lastly, PCOS cases were split into three subgroups based on IR centile to show the relationship between CCA and AUC.Results. There are strong inverse correlations between CCA-AUC versus HDL and SHBG (-0.98, -0.99), P < 0.0001. CCA-AUC correlated strongly and positively with [LDL, Cholesterol, LH/FSH, Serum Insulin, CCA-IMT, and HOMA-IR], r = (0.99,0.78,0.98,0.97,0.99,0.99) P< 0.0001. Sub-group analysis signified increased CCA-AUC with increasing IR severity (31.83 ± 3.90, 46.54 ± 5.03, 59.96 ± 2.57) P < 0.001; likewise, RI and PI of the CCA showed positive correlations (P = 0.040, P = 0.758) respectively. Conclusions.A strong correlation of CCA-AUC with all hormonals, biochemical, and biophysical changes among PCOS cases, in addition to its simplicity and accuracy, makes CCA-AUC a recommendable parameter in PCOS women for diagnostic and prognostic values.

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Section: Discussionmentioning

confidence: 99%

Section: Inclusion Criteria and Exclusion Criteriamentioning

confidence: 99%

Area Under the Curve of carotid artery Doppler as a sensitive marker of insulin sensitivity among Iraqi women with polycystic ovarian syndrome: a cross sectional study

Akram¹,

Nori²,

Zghair³

2023

It Journ Gyn Obs

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“…In the study by Patel et al, obese adolescents with PCOS had higher cIMT measurements than obese adolescents without PCOS [ 25 ]. In addition, no differences were observed between women with different PCOS phenotypes [ 45 ]. The discrepant results on cIMT values between studies might be due to the different prevalence of PCOS phenotypes and cardiovascular risk factors, as well as in methodological differences between the studies regarding study populations and methods of cIMT measurement [ 19 , 21 ].…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular Risk Factors and Subclinical Atherosclerosis in Greek Adolescents with Polycystic Ovary Syndrome: Its Relationship with Body Mass Index

et al. 2021

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Polycystic ovary syndrome (PCOS) is the most common endocrine condition affecting 6–18% of adolescents and is strongly associated with obesity and cardiovascular risk factors, enhancing the risk of atherosclerosis. Thirty-two adolescents with newly diagnosed PCOS were evaluated for lipid profile disorders, insulin resistance, inflammation, non-alcoholic fatty liver disease (NAFLD), and subclinical atherosclerosis through measurements of carotid intima–media thickness (cIMT). The relationships of the above markers with increased body mass index and abdominal obesity were investigated. Twenty-three adolescents (72%) were overweight (OW) or obese (OB). The OW/OB group had significantly higher insulin, HOMA-IR, high-sensitive C-reactive protein (hsCRP), visceral adiposity index (VAI), and lipid accumulation product (LAP) levels; and lower glucose-per-insulin ratios and HDL-C levels compared to the healthy weight group. The cIMT and small dense low-density lipoprotein cholesterol (sdLDL-C) levels did not differ between the two groups. Similarly, cIMT and sdLDL-C levels did not differ between PCOS-adolescents and healthy controls. CIMT was positively correlated with systolic blood pressure and waist circumference per height ratio. In conclusion, OW/OB PCOS-adolescents have a cluster of adverse factors predisposing them to atherosclerotic cardiovascular disease. Therefore, early cardiovascular risk assessment, as well as timely and targeted interventions, are necessary for prevention.

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“…Na presente pesquisa, o critério diagnóstico para SOP não foi avaliado, o que poderia ser considerado um viés para possíveis variações de RCV. Entretanto, Ramoglu et al (2017) (Alves & Faerstein, 2016).…”

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Excesso de peso e variáveis antropométricas de risco cardiovascular em portadoras da síndrome do ovário policístico

Coelho

Silva

Neris

et al. 2021

RSD

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Objetivo: avaliar a frequência de excesso de peso em mulheres com Síndrome dos Ovários Policísticos (SOP) e associações com o risco cardiovascular. Metodologia: estudo transversal, com 44 mulheres, com diagnóstico de SOP e idade entre 21 e 50 anos. Foram analisadas variáveis antropométricas (Índice de Massa Corporal - IMC, Circunferência da Cintura - CC, Razão Cintura-Quadril - RCQ e Razão Cintura-Estatura - RCEst), sociodemográficas (idade, renda, estado civil, sedentarismo, histórico familiar) e clínicas (presença de Diabetes Melito, Hipertensão Arterial Sistêmica e/ou Irregularidade Menstrual). Os testes estatísticos utilizados para frequências, associações e comparações, foram: Qui-quadrado, Exato de Fisher, F (ANOVA) e Kruskal-Wallis, com nível de significância de 5%. Resultados: a maioria do grupo apresentou obesidade (52,2%) seguido do sobrepeso (25%), RCEst elevado (72,7%), CC elevada (65,9%) e RCQ elevada (68,2%), com valor de P ≤ 0,001; sem patologias crônicas associadas; predominou mulheres jovens (21-39 anos), não brancas, solteiras, residentes no interior do estado, apresentando irregularidade menstrual e sedentarismo. Conclusão: o excesso de peso esteve presente em quase a totalidade da amostra, com todos os índices antropométricos evidenciando risco cardiovascular elevado, sendo a RCEst e a CC superiores ao IMC e RCQ na classificação do risco.

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Does cardiovascular risk vary according to the criteria for a diagnosis of polycystic ovary syndrome?

Abstract: Because PCOS and atherosclerosis both have a complex nature, it is likely that the evaluation of CIMT alone may not be sufficient to determine endothelial dysfunction in a reproductive age group.

Cited by 15 publications

References 35 publications

Area Under the Curve of carotid artery Doppler as a sensitive marker of insulin sensitivity among Iraqi women with polycystic ovarian syndrome: a cross sectional study

Area Under the Curve of carotid artery Doppler as a sensitive marker of insulin sensitivity among Iraqi women with polycystic ovarian syndrome: a cross sectional study

Cardiovascular Risk Factors and Subclinical Atherosclerosis in Greek Adolescents with Polycystic Ovary Syndrome: Its Relationship with Body Mass Index

Excesso de peso e variáveis antropométricas de risco cardiovascular em portadoras da síndrome do ovário policístico

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