PurposeThis study empirically investigates the moderating effect of institutions (including formal institutions and informal institutions) on the relationship between FDI and regional technology-based entrepreneurship in China’s emerging economy.Design/methodology/approachBy collecting data on technology-based entrepreneurship at the regional level in China, our final balanced panel comprises 81,926 technology start-ups in 29 provinces at the regional level from 2000 to 2014.FindingsThe results show that FDI is critical to encouraging technology-based start-ups. We also argue that the institutions positively moderate the relationship between FDI and regional technology-based entrepreneurship. This study supports the negative interaction effect of FDI and corruption on technology-based entrepreneurship in eastern regions, suggesting that corruption weakens FDI’s entrepreneurial enthusiasm.Originality/valueThis study contributes to the literature by highlighting the critical role of regional formal institutions in moderating the positive effects of FDI on technology-based entrepreneurship. This enriches the knowledge spillover theory of entrepreneurship and the OLI paradigm, offering a fresh perspective on this complex relationship. Additionally, it provides nuanced insights into how corruption, as an informal institution, interacts with FDI in different regional contexts.