Does Croton Argyrophyllus Extract Has an Effect on Muscle Damage and Lipid Peroxidation in Rats Submitted to High Intensity Strength Exercise?

Abstract

Many species of the genus Croton have been used for anti-inflammatory, antiproliferative, antidiabetic, and antitumor purposes. The objective was to evaluate the effect of a hydroethanolic extract (HEE) from the inner bark of Croton argyrophyllus (Euphorbiaceae) on muscle damage and oxidative stress in rats after high intensity exercise. The animals were divided into four groups: (i) the sedentary group (SV; n = 7), (ii) the exercise vehicle group (EV, n = 7), (iii) the sedentary group HEE (SHG; n = 7) composed of sedentary animals and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.), and (iv) the HEE exercise group (HEE; n = 7) composed of animals submitted to resistance exercise (RE) and treated with the hydroethanolic extract of C. argyrophyllus (200 mg/kg, v.o.). In the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) test, the HEE showed lower values of inhibition potential (IP%) at 39.79% compared to gallic acid, 87.61%, and lipoperoxidation inhibition at 27.4% (100 µg/mL) or 28.6% (200 µg/mL) (p < 0.001). There was inhibition in free radicals in vivo. The HEE of C. argyrophyllus partially reduced the biomarkers of oxidative stress in muscle tissue and muscular damage (creatine kinase (CK) and Lactate Dehydrogenase (LDH)) (p < 0.05) in rats, and in this sense it can be an aid to the recovery process after exhaustive efforts.

Resistance Circuit Training or Walking Training: Which Program Improves Muscle Strength and Functional Autonomy More in Older Women?

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Effects of Ibuprofen Use on Lymphocyte Count and Oxidative Stress in Elite Paralympic Powerlifting

“…This would happen due to the imbalance between the production of reactive oxygen species (ROSs) and the endogenous antioxidant activity. Although ideal ROS production is important for muscle contraction, high ROSs concentrations tend to promote exerciseinduced fatigue [50,51].…”

Croton argyrophyllus Kunth Essential Oil-Loaded Solid Lipid Nanoparticles: Evaluation of Release Profile, Antioxidant Activity and Cytotoxicity in a Neuroblastoma Cell Line

“…Its anti-inflammatory activity was also described in Wistar rats, as shown by a significant inhibition of paw edema formation and leukocyte influx induced by 1% carrageenan solution [15]. The recent work published by de Araújo et al (2019) [16], by studying the properties of the inner bark of Croton argyrophyllus (Euphorbiaceae), reported how hydroethanolic extract can partially reduce the biomarkers of oxidative stress in muscle tissue, and thus muscular damage in rats that were submitted to high intensity strength exercise [16]. The antioxidant properties represent the first stage of evaluation of health properties of food matrices and result from the combination of bioactive compounds [17][18][19], thereby attracting high scientific interest [20].…”