Does exposure of pregnant women to epidemic respiratory syncytial virus affect the severity of bronchiolitis?

Fernández, J.M. Ramos; Hernández-Yuste, Alexandra; Gutiérrez‐Bedmar, Mario; Martínez, Ana María Cordón; Moreno-Pérez, David

doi:10.1016/j.eimc.2018.07.002

Cited by 7 publications

(5 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…16,17 A retrospective cohort study indicated that the reduced exposure of pregnant women to RSV epidemic contributed to more severe RSV-induced bronchiolitis in children under 6 months of age. 18 Therefore, RSV-induced bronchiolitis is common in 6 months age; this may be associated with the circulation of antibodies that are not associated with RSV infection during pregnancy. Further investigations are necessary to identify specific susceptibility factors.…”

Section: Discussionmentioning

confidence: 99%

Etiology and Clinical characteristics of bronchiolitis in Suzhou

Tan

Jiang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Bronchiolitis is a clinical syndrome commonly encountered in practice, particularly among infants and young children. However, the etiology and clinical impact of the condition remains elusive.Methods We investigated the respiratory specimens and clinical data of 1012 children with bronchiolitis who were treated at the Children’s Hospital of Soochow University between November 2011 and December 2018. The nasopharyngeal aspirates were examined by direct immunofluorescence assay or polymerase chain reaction (PCR) to detect viruses and by PCR and enzyme-linked immunosorbent assay to detect Mycoplasma pneumoniae (MP).Results Of the 1012 children with bronchiolitis, 842 (83.2%) were detected at least a pathogen. 614 (60.7%) had single viral infections, 91 (9.0%) had MP infections, 70 (6.9%) had multiple viral infections, and 67 (6.6%) had mixed viral and MP infection. The most common pathogens detected were respiratory syncytial virus (RSV) (44.4%), MP (15.6%), and human rhinovirus (HRV) (14.4%). RSV was the most common pathogen detected in children less than 6 months. Coinfection was detected in 13.5% (137/1012) of the children, but it was less common in children less than 6 months. The age of children with single virus infection was the youngest. Children with single virus infection had a higher proportion of oxygen therapy compared with single MP infection.Conclusions The most common pathogen detected in children with bronchiolitis is RSV, followed by MP and HRV. Co-infections lead to prolonged illness and worsening of the symptoms

show abstract

Section: Discussionmentioning

confidence: 99%

Etiology and Clinical characteristics of bronchiolitis in Suzhou

Tan

Jiang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…A total of 72 infants (≤12months) hospitalized in Children's Hospital of Soochow University were enrolled in this study, and divided into RSV infection group (n=50) and control group (non-RSV-infection, n=22). RSV infection was diagnosed by respiratory symptoms (such as wheezing, cough and tachypnea) accompanied with the positive of RSV speci c polymerase chain reaction (PCR) based assay (16,17).…”

Section: Patients and Ethics Statementmentioning

confidence: 99%

IFI27 May Predict and Evaluate the Severity of Respiratory Syncytial Virus Infection in Preterm Infants

Gao

Zhu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Preterm infants are a special population that vulnerable to respiratory syncytial virus (RSV) infection and the lower respiratory tract infection (LRTIs) caused by RSV could be severe and even life-threating. The purpose of the present study was to identify candidate genes of preterm infants who are susceptible to RSV infection and provide a new insight into the pathogenesis of RSV infection. Methods: Three datasets (GSE77087, GSE69606 and GSE41374) containing 183 blood samples of RSV infected patients and 33 blood samples of healthy controls from Gene Expression Omnibus (GEO) database were downloaded and the differentially expressed genes (DEGs) were screened out. The function and pathway enrichments were analyzed through Database for Annotation, Visualization and Integrated Discovery (DAVID) website. The protein‐protein interaction (PPI) network for DEGs was constructed through Search Tool for the Retrieval of Interacting Genes (STRING). The module analysis was performed by Cytoscape software and hub genes were identified. Clinical verification was employed to verify the expression level of top five hub genes among 72 infants including 50 RSV infected patients and 22 non-RSV-infected patients hospitalized in our center. Further, the RSV infected infants with high-expression IFI27 and those with low-expression IFI27 were compared (defined as higher or lower than the median mRNA level). Finally, the gene set enrichment analysis (GSEA) focusing on IFI27 was carried out. Results: Totally, 4028 DEGs were screened out and among which, 131 most significant DEGs were selected. Subsequently, 13 hub genes were identified and function and pathway enrichments of hub genes mainly were: response to virus, defense response to virus, regulation of viral genome replication and regulation of viral life cycle. Furthermore, IFI27 was confirmed to be the most significantly expressed in clinical verification. Gene sets associated with calcium signaling pathway, arachidonic acid metabolism, extracellular matrix receptor interaction and so on were significantly enriched when IFI27 was highly expressed. Moreover, high-expression IFI27 was associated with more severe cases (p=0.041), more requirements of mechanical ventilation (p=0.034), more frequent hospitalization (p<0.001) and longer cumulative hospital stay (p=0.012). Conclusion: IFI27 might serve to predict RSV infection and evaluate the severity of RSV infection in preterm infants.

show abstract

“…18,19 A retrospective cohort study indicated that the reduced exposure of pregnant women to RSV epidemic contributed to more severe RSV-induced bronchiolitis in children under 6 months of age. 20 Therefore, RSV-induced bronchiolitis is common in 6 months age; this may be associated with the circulation of antibodies that are not associated with RSV infection during pregnancy. Further investigations are necessary to identify speci c susceptibility factors.…”

Section: Discussionmentioning

confidence: 99%

Etiology, clinical characteristics and coinfection status of bronchiolitis in Suzhou

Tan

Jiang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Bronchiolitis is a clinical syndrome commonly encountered in practice, particularly among infants and young children. To investigate the prevalence of pathogens in hospitalized children with bronchiolitis and study the clinical characteristics of bronchiolitis with or without coinfections. Methods: We investigated the respiratory specimens and clinical data of 1012 children with bronchiolitis who were treated at the Children’s Hospital of Soochow University between November 2011 and December 2018. The nasopharyngeal aspirates were examined to detect viruses by direct immunofluorescence assay or polymerase chain reaction (PCR). Mycoplasma pneumoniae (MP) was tested by PCR and enzyme-linked immunosorbent assay.Results: Of the 1012 children less than 2 years with bronchiolitis, causative pathogen was detected in 83.4% (842 of 1012). The majority of these (614 [72.9%] of 842) were single virus infection. The most common pathogens detected were respiratory syncytial virus (RSV) (44.4%), MP (15.6%), and human rhinovirus (HRV) (14.4%). Coinfection was identified in 13.5% (137 of 1012) of the patients. Coinfection includes virus mixed virus infection and virus mixed MP infection. Children with single virus infection had a higher rate of oxygen therapy compared with single MP infection. Conclusions: The most common pathogen detected in children with bronchiolitis is RSV, followed by MP and HRV. The high mix infection burden in bronchiolitis underscores a need for the sensitive and rapid diagnostics to accurately identify pathogens.

show abstract

Does exposure of pregnant women to epidemic respiratory syncytial virus affect the severity of bronchiolitis?

Cited by 7 publications

References 29 publications

Etiology and Clinical characteristics of bronchiolitis in Suzhou

Etiology and Clinical characteristics of bronchiolitis in Suzhou

IFI27 May Predict and Evaluate the Severity of Respiratory Syncytial Virus Infection in Preterm Infants

Etiology, clinical characteristics and coinfection status of bronchiolitis in Suzhou

Contact Info

Product

Resources

About