Does Helicobacter pylori infection protect against esophageal diseases in Asia?

Wu, Justin C. Y.

doi:10.1007/s12664-011-0124-6

Cited by 4 publications

(4 citation statements)

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“…Patients who underwent H. pylori eradication treatment in our department between 2008 and 2013 and in whom H. pylori was successfully eradicated were enrolled in this study. A 13 C-urea breath test result of 2.5‰ or less (Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan), or negative result on the stool H. pylori antigen test 6 weeks after the end of eradication treatment (SRL, Inc., Tokyo, Japan) was considered as successful eradication of H. pylori. Inclusion criteria were the following: patients who underwent endoscopy within 1 year before the start of eradication treatment and had images of the gastroesophageal junction that could be used to determine the presence or absence of RE, and who underwent endoscopy 3 years or more than 3 years after eradication treatment and had the same images as those described above.…”

Section: Subjectsmentioning

confidence: 99%

“… 9 , 10 The gastric acid secretion capacity of H. pylori -infected persons is often lower than that of uninfected persons, and the H. pylori infection rate is said to be inversely correlated with the prevalence of RE. 11 – 14 Eradication treatment of H. pylori results in elimination of inflammatory cell infiltration and may lead to improvement of atrophy. 6 It has been reported that elimination of inflammation and improvement of atrophy restore gastric acid secretion.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between Helicobacter pylori infection and reflux esophagitis and the long-term effects of eradication of Helicobacter pylori on reflux esophagitis

Hojo

Takeda

Akazawa

et al. 2021

Therap Adv Gastroenterol

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Introduction: Whether the incidence of reflux esophagitis (RE) increases after the eradication of Helicobacter pylori ( H. pylori) is controversial. Few reports have evaluated the presence or absence of RE after a long period of time, taking into account the degree of atrophy and/or administration of acid secretion inhibitors. We investigated the relationship between H. pylori and RE taking into account these factors. Methods: This was a retrospective cohort study with approval by the Ethics Committee. Patients who succeeded in H. pylori eradication treatment, and in whom there were images of the gastroesophageal junction on endoscopic examinations within 1 year before eradication treatment and more than 3 years after eradication were included. The degrees of RE and atrophy were retrospectively determined from the endoscopic images. The prevalence of RE before and after eradication and the incidence of newly developed RE after eradication between patients with or without atrophy improvement were compared using Fisher’s exact test. Results: A total of 185 cases (male:female = 104:81; mean age, 63.5 years; mean observation period, 6.4 years) were examined. The prevalence of RE before and after eradication was 1.6% (3/185) and 7.0% (13/185), respectively ( P = 0.019). RE was present in 8 (7.5%) of 106 cases with closed-type atrophy and in 5 (6.3%) of 79 cases with open-type atrophy after eradication ( P = 0.75). Atrophy improved after eradication in 56 cases, of whom 4 (7.1%) had new onset of RE; the degree of atrophy did not improve in 126 cases, of whom 7 (5.4%) had new onset of RE ( P = 0.74). There was no difference between the percentage of cases who took acid secretion inhibitors before and after eradication ( P = 0.14). Conclusion: The prevalence of RE increased a long time after eradication, even in patients who were taking an acid secretion inhibitor. The prevalence of RE was not related to the degree of atrophy or change in atrophy.

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Section: Subjectsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The relationship between Helicobacter pylori infection and reflux esophagitis and the long-term effects of eradication of Helicobacter pylori on reflux esophagitis

Hojo

Takeda

Akazawa

et al. 2021

Therap Adv Gastroenterol

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“…46 On the other hand, H. pylori infection is reported to be more frequently seen in low socioeconomic state. 47 As a consequent, low socioeconomic people might have more prevalence of H. pylori infection, which in turn, this infection might have protected them from GERD. So a further step in this study would be the evaluation of H. pylori infection in the GERD population of both high and low socioeconomic statuses in a comparative manner.…”

Section: Discussionmentioning

confidence: 99%

Socioeconomic Inequalities in Gastroesophageal Reflux Disorder: Results from an Iranian Cohort Study

Farjam

Sharafi

Bahramali

et al. 2018

Middle East J Dig Dis

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BACKGROUND Despite progress in the health indexes in recent years, health inequalities remain as a global challenge within and between regions and countries. This study is the first to quantify the socioeconomic inequity in gastroesophageal reflux disease (GERD) using the concentration index. METHODS In this cross-sectional study, we used baseline data (7012 subjects) from the Fasa Cohort Study (the Southern Iran). The principal component analysis was used to construct socioeconomic status of the participants. The concentration index and concentration curve were used to measure socioeconomic-related inequality in GERD. Decomposition of concentration index was also done to identify the contribution of each explanatory variable to the wealth-related inequality in GERD prevalence. RESULTS The prevalence of GERD was 16.9% (95% CI: 15.9-17.7%). The overall concentration index for GERD was 0.093 (95% CI: 0.062-0.166]. Correspondingly, this figure for men and women were 0.116 (95% CI: 0.062-0.171%) and 0.091 (95% CI: 0.044-0.137%), respectively. The main contributors of socioeconomic-related inequality in GERD prevalence were socioeconomic status (64.4%), alcohol drinking (29%), and age (8.4%). CONCLUSION GERD is significantly more concentrated among richest people. There was significant socioeconomic inequality in GERD according to some individual factors. These inequalities need to be addressed by policy makers to identify the vulnerable subgroups and to reduce the disease burden in the community.

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“…In Asia including Japan, CagA‐ VacA‐positive virulent strains are common 12 , 13 . Such preponderance of CagA‐ and VacA‐positive strains and proinflammatory interleukin‐1 beta polymorphism are supposed to increase the risk of hypochlohydria and protects against the development of GORD in the Asian population 14 . In case of patients with corpus dominant gastritis, we should be wary of the development of new GORD; however, when it does develop, it is not so severe.…”

Section: Does H Pylori Eradication Develop New Gord?mentioning

confidence: 99%

Do we need to eradicate Helicobacter pylori in patients with GORD?

Masaoka

Suzuki

2013

UEG Journal

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Eradication of Helicobacter pylori should not be avoided because of complicated reflux symptoms. Previously, although H. pylori eradication in patients with GORD was considered to induce unfavourable effects that worsen reflux symptoms, recent reports indicates that it can have favourable consequences by reducing symptoms and therefore improving quality of life, especially in GORD patients without severe corpus atrophy or severe hiatal herniation.

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Does Helicobacter pylori infection protect against esophageal diseases in Asia?

Cited by 4 publications

References 50 publications

The relationship between Helicobacter pylori infection and reflux esophagitis and the long-term effects of eradication of Helicobacter pylori on reflux esophagitis

The relationship between Helicobacter pylori infection and reflux esophagitis and the long-term effects of eradication of Helicobacter pylori on reflux esophagitis

Socioeconomic Inequalities in Gastroesophageal Reflux Disorder: Results from an Iranian Cohort Study

Do we need to eradicate Helicobacter pylori in patients with GORD?

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