Does Inclusion of Interactions Result in Higher Precision of Estimated Health State Values?

Nicolet, Anna; Groothuis-Oudshoorn, Catharina Gerarda Maria; Krabbe, Paul F M

doi:10.1016/j.jval.2018.06.001

Cited by 12 publications

(5 citation statements)

References 33 publications

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“…Results are shown in Table 1 in the supplementary material. Similar to the findings of Nicolet et al (2018), we found that including all two-way interaction effects slightly improved model fit [ 36 ]. In the interaction model, it is important to refrain from interpreting isolated main effects from interaction effects, as such interpretations can be misleading.…”

Section: Resultssupporting

confidence: 89%

Willingness to provide informal care to older adults in Germany: a discrete choice experiment

Jong

Schmidt

Stahmeyer³

et al. 2022

Eur J Health Econ

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As the German population is continually aging and the majority of older adults still wish to ‘age in place’, the need for informal care provided by family and friends will correspondingly continue to increase. In addition, while the need for formal (professional) care services is also likely to increase, the supply already does not meet the demand in Germany today. The aim of our study is the elicitation of people’s willingness to provide informal care by means of a discrete choice experiment. The self-complete postal survey was disseminated to a random sample of the German general population in Lower Saxony. Data cleansing resulted in a final sample size of 280 participants. A conditional logit and a latent class model were estimated. All attributes were judged as highly relevant by the respondents. The results revealed that an increase in the care hours per day had the greatest negative impact overall on the willingness to provide informal care in our sample. The marginal willingness-to-accept for 1 h of informal care was €14.54 when having to provide informal care for 8 h in reference to 2 h per day. This value is considerably higher than the national minimum wage of €9.82. A three-class latent class model revealed preference heterogeneity. While a monetary compensation is often discussed to increase the willingness and availability of informal care in a country, our results show that this statement could not be generalized within our entire sample.

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Section: Resultssupporting

confidence: 89%

Willingness to provide informal care to older adults in Germany: a discrete choice experiment

Jong

Schmidt

Stahmeyer³

et al. 2022

Eur J Health Econ

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show abstract

“…This seemed reasonable, because it is commonly used to represent health state preferences -most EQ-5D-5L value sets are based on such a model. When studies test for and include interaction effects, authors also often find only minor improvements in the explanatory power 35 .…”

Section: Discussionmentioning

confidence: 99%

The Online Elicitation of Personal Utility Functions (OPUF) tool: a new method for valuing health states

Schneider¹,

Hout²,

Heisen³

et al. 2022

Wellcome Open Res

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Introduction Standard valuation methods, such as TTO and DCE are inefficient. They require data from hundreds if not thousands of participants to generate value sets. Here, we present the Online elicitation of Personal Utility Functions (OPUF) tool; a new type of online survey for valuing EQ-5D-5L health states using more efficient, compositional elicitation methods, which even allow estimating value sets on the individual level. The aims of this study are to report on the development of the tool, and to test the feasibility of using it to obtain individual-level value sets for the EQ-5D-5L. Methods We applied an iterative design approach to adapt the PUF method, previously developed by Devlin et al., for use as a standalone online tool. Five rounds of qualitative interviews, and one quantitative pre-pilot were conducted to get feedback on the different tasks. After each round, the tool was refined and re-evaluated. The final version was piloted in a sample of 50 participants from the UK. A demo of the EQ-5D-5L OPUF survey is available at: https://eq5d5l.me Results On average, it took participants about seven minutes to complete the OPUF Tool. Based on the responses, we were able to construct a personal EQ-5D-5L value set for each of the 50 participants. These value sets predicted a participants' choices in a discrete choice experiment with an accuracy of 80%. Overall, the results revealed that health state preferences vary considerably on the individual-level. Nevertheless, we were able to estimate a group-level value set for all 50 participants with reasonable precision. Discussion We successfully piloted the OPUF Tool and showed that it can be used to derive a group-level as well as personal value sets for the EQ-5D-5L. Although the development of the online tool is still in an early stage, there are multiple potential avenues for further research.

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“…A multiplicative interaction term between injection device type and frequency of injection was included in the model as these two attributes were hypothesized to be conceptually related (eg, preference for the frequency of injections may vary depending upon the type of injection device); in such cases, interaction terms are recommended. 14,15 Regression coefficients were also used to assess the relative importance of treatment attributes in participants' preference decisions among all attributes and among attributes that were significantly associated with treatment preference. To facilitate the interpretation, the relative importance of treatment efficacy outcomes was quantified as follows: 60% reduction in the frequency of severe asthma attacks (an efficacy estimate found in clinical trials) 16,17 and 250 mL improvement in lung function (an improvement that is considered moderately better by patients).…”

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Patient Preferences for Attributes of Biologic Treatments in Moderate to Severe Asthma: A Discrete Choice Experiment Study

Yang¹,

Chao²,

Fillbrunn³

et al. 2022

PPA

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Purpose Multiple biologics are available for moderate to severe asthma. Given the important relationship between patient engagement in healthcare decision-making and health outcomes, patient preference is an increasingly important consideration. This study elicited patients’ preferences for attributes of biologic therapies for moderate to severe asthma. Patient and Methods A discrete choice experiment (DCE) questionnaire was designed to collect data from an existing survey panel of adults with moderate to severe asthma in the United States. Patients were asked to select their preferred hypothetical treatment from profiles with varying attributes related to efficacy, safety, and administration convenience. Conditional logit regression models were used to quantify patient preferences. Results Of 301 eligible patients who completed the survey, the mean age was 46.7±15.1 years and 71.8% were female. Patients had asthma for 22.5±16.3 years on average, and most (97.3%) had experienced ≥1 asthma attack in the past 12 months. Among treatment attributes examined, patients most valued the absence of a black box warning for the risk of a life-threatening allergic reaction, effectiveness of reducing severe asthma exacerbations, and improvement in lung function (all p < 0.001). Home administration setting for subcutaneous injections (vs doctor’s office/clinic) (p = 0.009) and ability of a biologic to treat additional chronic condition(s) (p < 0.05) were also considered important. Dosing frequency and type of injection device were not significant factors. Conclusion Patients with moderate to severe asthma valued efficacy and safety over convenience attributes when selecting biologic treatments. Awareness of these preferences can facilitate patient-physician shared decision-making when managing moderate to severe asthma in clinical practice.

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Does Inclusion of Interactions Result in Higher Precision of Estimated Health State Values?

Cited by 12 publications

References 33 publications

Willingness to provide informal care to older adults in Germany: a discrete choice experiment

Willingness to provide informal care to older adults in Germany: a discrete choice experiment

The Online Elicitation of Personal Utility Functions (OPUF) tool: a new method for valuing health states

Patient Preferences for Attributes of Biologic Treatments in Moderate to Severe Asthma: A Discrete Choice Experiment Study

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