Does insulin play a role in cardiovascular autonomic regulation?

Sima, Aurélia

doi:10.2337/diacare.23.6.724

Cited by 8 publications

(6 citation statements)

References 19 publications

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“…However, using modern methods autonomic nervous system dysregulation can be revealed even in early phases of DM (Ziegler, 1994;Spallone et al, 1995;Scaramuzza et al, 1998;Sima, 2000). The autonomic neuropathy is traditionally considered as one of the late complications of DM.…”

Section: Introductionmentioning

confidence: 99%

“…The autonomic neuropathy is traditionally considered as one of the late complications of DM. However, using modern methods autonomic nervous system dysregulation can be revealed even in early phases of DM (Ziegler, 1994;Spallone et al, 1995;Scaramuzza et al, 1998;Sima, 2000). Although multicentric study EURODIAB have found the presence of cardiac autonomic neuropathy in 19% of diabetics in the age group 15-29 years (Donaghue, 1998), relatively few studies were focused on autonomic neuropathy in adolescents and young adults with DM type 1.…”

Section: Introductionmentioning

confidence: 99%

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Heart rate variability in young patients with diabetes mellitus and healthy subjects explored by Poincaré and sequence plots

Javorka

Javorková

Tonhajzerová

et al. 2005

Clin Physio Funct Imaging

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Autonomic neuropathy is a common complication of the diabetes mellitus (DM). The significance of its early diagnosis is very high because the mortality of the patients with this complication is elevated. Considering the effort to apply new mathematical methods to cardiac dysregulation diagnosis, the major aim of the study was to ascertain which of the new heart rate variability (HRV) parameters are different in young patients with DM type 1 compared with control group. The next aim was to assess the HRV changes during prolonged (40 min) supine rest. The heart rate was continuously recorded during supine rest in 17 young patients with DM type 1 (10 women, 7 men) aged 22.4 +/- 1.0 years (mean +/- SEM). The control group consisted of 17 healthy matched probands. The HRV (time/frequency domains, Poincare and sequence plots, sample entropy) was analysed in two intervals - T1 starting at fifth minute and T2 starting at 30th minute of supine rest. The major results of our study are: the reduced Poincare plot pattern measures in the young DM group; the lower percentage of points in the third quadrant of sequence plot (this parameter was not correlated with the mean heart rate) and significant changes in HRV during supine rest in DM group (in contrast to control subjects). In conclusion, HRV parameters based on nonlinear dynamics were able to distinguish cardiac dysregulation in young patients with DM from the control group. The percentage of points in the third quadrant of sequence plot provides information that is not dependent on mean heart rate. Poincare and sequence plots, together with the rate of HRV changes during supine rest, can provide clinically relevant information usable in diagnosis of the cardiac dysregulation.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Heart rate variability in young patients with diabetes mellitus and healthy subjects explored by Poincaré and sequence plots

Javorka

Javorková

Tonhajzerová

et al. 2005

Clin Physio Funct Imaging

View full text Add to dashboard Cite

show abstract

“…Autonomic neuropathy is considered as one of the late complications of DM. However, autonomic nervous system dysregulation can be detected by modern sensitive methods even in early phases of DM (Ziegler, 1994;Spallone et al, 1995;Scaramuzza et al, 1998;Sima, 2000).…”

Section: Introductionmentioning

confidence: 99%

Parasympathetic versus sympathetic control of the cardiovascular system in young patients with type 1 diabetes mellitus

Javorka

Javorková

Tonhajzerová

et al. 2005

Clin Physio Funct Imaging

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Autonomic neuropathy and cardiovascular dysregulation are common complications of the diabetes mellitus (DM). The aim of the study was to test the hypothesis that cardiovascular regulation is abnormal in young patients with type 1 DM. Patients with type 1 DM (17, 10 females, 7 males) aged 12.9-31.5 years (mean+/-SEM: 22.4+/-1.0 years) were investigated. The mean duration of DM was 12.4+/-1.2 years. The control group consisted of 17 healthy probands matched for sex and age. The length of R-R intervals was measured using telemetric system (VariaCardio TF4; Sima Media) where ECG signal (sampling frequency 1000 Hz) from thoracic belt was transferred into PC for further analysis. Systolic blood pressure (SBP) was monitored beat-to-beat using volume-clamp method by Finapres 2300 (Ohmeda). Spectral power in HF band of HRV (HRV-HF) was taken as an index of parasympathetic control and spectral power in LF band of systolic BPV (BPV-LF) as an index of sympathetic control. In young patients with type 1 DM significant reduction of spectral power in HF band of the heart rate variability was found, whereas no significant difference between DM group and control group was observed in spectral power in LF band of blood pressure variability. In conclusion, we found impaired parasympathetic control of heart rate in young patients with type 1 DM. No differences in blood vessels sympathetic control were detected using spectral analysis of BPV. We suggest that abnormalities in cardiac parasympathetic regulation precede impairment of blood vessels sympathetic control in young diabetics.

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“…We emphasize the need for knowledge of physiology and pathophysiology in order to correctly understand, apply, and interpret autonomic tests, as well as the various factors that can alter their results, such as age, gender, body position, time of day, prior physical activity, nutrition, BP, HR, respiratory rate baseline, coffee ingestion, use of cigarettes, mental stress, hyperglycemia and hypoglycemia, and insulinemia. Hyperinsulinemia seems to be related to an increase in plasma norepinephrine and a decrease in parasympathetic control of HR caused by insulin itself ( 11 ). Furthermore, insulin affects blood vessel tone and can induce vasodilation and hypotension.…”

Section: Critical Analysis Of Hrvmentioning

confidence: 99%

Tests for Early Diagnosis of Cardiovascular Autonomic Neuropathy: Critical Analysis and Relevance

2013

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Does insulin play a role in cardiovascular autonomic regulation?

Cited by 8 publications

References 19 publications

Heart rate variability in young patients with diabetes mellitus and healthy subjects explored by Poincaré and sequence plots

Heart rate variability in young patients with diabetes mellitus and healthy subjects explored by Poincaré and sequence plots

Parasympathetic versus sympathetic control of the cardiovascular system in young patients with type 1 diabetes mellitus

Tests for Early Diagnosis of Cardiovascular Autonomic Neuropathy: Critical Analysis and Relevance

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